GPI8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPI8_HUMAN
• UniProt AC: Q92643
• Protein Name: GPI-anchor transamidase
• Gene Name: PIGK
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
• Protein Description: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein..
• Protein Sequence: MAVTDSLSRAATVLATVLLLSFGSVAASHIEDQAEQFFRSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLADDMACNPRNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGRIPPSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNIELADAFEQMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDPAIGVHLMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRTDLFQRDPKNVLITDFFGSVRKVEITTETIKLQQDSEIMESSYKEDQMDEKLMEPLKYAEQLPVAQIIHQKPKLKDWHPPGGFILGLWALIIMVFFKTYGIKHMKFIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	RHVANTLSVYRSVKR HHHHHHHHHHHHHHH	18.31	24719451
69	Phosphorylation	VANTLSVYRSVKRLG HHHHHHHHHHHHHHC	8.19	-
98	Ubiquitination	ACNPRNPKPATVFSH CCCCCCCCCCEECEE	51.32	21963094
106	Ubiquitination	PATVFSHKNMELNVY CCEECEECCEEEEEE	57.71	21963094
142	Phosphorylation	LTGRIPPSTPRSKRL HHCCCCCCCCCHHHC	45.77	28188228
143	Phosphorylation	TGRIPPSTPRSKRLL HCCCCCCCCCHHHCC	28.61	23403867
151	Phosphorylation	PRSKRLLSDDRSNIL CCHHHCCCCCCCCEE	41.90	24719451
155	Phosphorylation	RLLSDDRSNILIYMT HCCCCCCCCEEEEEE	34.91	28348404
193	Ubiquitination	AFEQMWQKRRYNELL HHHHHHHHHCCCCEE	24.27	21906983
212	Phosphorylation	TCQGASMYERFYSPN CCCCHHHHHHHHCCC	11.06	-
216	Phosphorylation	ASMYERFYSPNIMAL HHHHHHHHCCCCHHH	29.46	20860994
225	Phosphorylation	PNIMALASSQVGEDS CCCHHHHHCCCCCCH	23.35	20860994
296	Ubiquitination	DLFQRDPKNVLITDF CHHHCCCCCEEEEEC	65.07	21906983
296	2-Hydroxyisobutyrylation	DLFQRDPKNVLITDF CHHHCCCCCEEEEEC	65.07	-
301	Phosphorylation	DPKNVLITDFFGSVR CCCCEEEEECCCCEE	23.69	-
306	Phosphorylation	LITDFFGSVRKVEIT EEEECCCCEEEEEEE	17.37	-
309	Ubiquitination	DFFGSVRKVEITTET ECCCCEEEEEEEECE	41.90	16196087
314	O-linked_Glycosylation	VRKVEITTETIKLQQ EEEEEEEECEEEHHH	36.47	OGP
318	Ubiquitination	EITTETIKLQQDSEI EEEECEEEHHHCHHH	47.89	21963094
331	Ubiquitination	EIMESSYKEDQMDEK HHHHHCCCHHHHCHH	57.68	21906983
344	Ubiquitination	EKLMEPLKYAEQLPV HHHHHHHHHHHHCCH	53.80	21963094
358	Ubiquitination	VAQIIHQKPKLKDWH HHHHHCCCCCCCCCC	29.92	21906983
360	Ubiquitination	QIIHQKPKLKDWHPP HHHCCCCCCCCCCCC	75.18	22817900
362	Ubiquitination	IHQKPKLKDWHPPGG HCCCCCCCCCCCCCH	65.97	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPI8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPI8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPI8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIGT_HUMAN	PIGT	physical	12582175
CALX_HUMAN	CANX	physical	12582175
ULBP2_HUMAN	ULBP2	physical	12582175
PPB1_HUMAN	ALPP	physical	11278620
GPAA1_HUMAN	GPAA1	physical	10793132
GPAA1_HUMAN	GPAA1	physical	12052837
PIGT_HUMAN	PIGT	physical	22939629
PIGS_HUMAN	PIGS	physical	22939629
PIGU_HUMAN	PIGU	physical	22939629
PIGT_HUMAN	PIGT	physical	26186194
GPAA1_HUMAN	GPAA1	physical	26186194
PIGS_HUMAN	PIGS	physical	26186194
PIGU_HUMAN	PIGU	physical	26186194
GPAA1_HUMAN	GPAA1	physical	28514442
PIGU_HUMAN	PIGU	physical	28514442
PIGT_HUMAN	PIGT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.