CHPF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHPF2_HUMAN
• UniProt AC: Q9P2E5
• Protein Name: Chondroitin sulfate glucuronyltransferase
• Gene Name: CHPF2
• Organism: Homo sapiens (Human).
• Sequence Length: 772
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
• Protein Description: Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity..
• Protein Sequence: MRLSSLLALLRPALPLILGLSLGCSLSLLRVSWIQGEGEDPCVEAVGERGGPQNPDSRARLDQSDEDFKPRIVPYYRDPNKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGARAPAGMQVVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDLYLGRAEEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGCRGDILSARPDEWLGRCLIDSLGVGCVSQHQGQQYRSFELAKNRDPEKEGSSAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPVGLPAPFTPHSRFEVLGWDYFTEQHTFSCADGAPKCPLQGASRADVGDALETALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLECVTQRGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAAAAPAFLEAFAANVLEPREHALLTLLLVYGPREGGRGAPDPFLGVKAAAAELERRYPGTRLAWLAVRAEAPSQVRLMDVVSKKHPVDTLFFLTTVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGPPGAGPDPPSPPGADPSRGAPIGGRFDRQASAEGCFYNADYLAARARLAGELAGQEEEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLGGRAQLAMALFEQEQANST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	GGPQNPDSRARLDQS CCCCCCCCCCCCCCC	29.15	28509920
64	Phosphorylation	SRARLDQSDEDFKPR CCCCCCCCCCCCCCC	42.51	28355574
69	Ubiquitination	DQSDEDFKPRIVPYY CCCCCCCCCCCCCCC	45.79	-
83	Phosphorylation	YRDPNKPYKKVLRTR CCCCCCCHHHHHHHH	25.67	24719451
89	Phosphorylation	PYKKVLRTRYIQTEL CHHHHHHHHHCHHHC	24.54	24719451
91	Phosphorylation	KKVLRTRYIQTELGS HHHHHHHHCHHHCCC	9.21	24905233
94	Phosphorylation	LRTRYIQTELGSRER HHHHHCHHHCCCHHH	24.50	24905233
98	Phosphorylation	YIQTELGSRERLLVA HCHHHCCCHHHHHHH	43.52	24905233
121	N-linked_Glycosylation	STLAVAVNRTVAHHF HHHHHHHHHHHHHHC	24.94	UniProtKB CARBOHYD
229	Phosphorylation	YCHGGFGYLLSRSLL HCCCCHHHHHCHHHH	11.38	30576142
232	Phosphorylation	GGFGYLLSRSLLLRL CCHHHHHCHHHHHHH	19.75	30576142
252	Phosphorylation	GCRGDILSARPDEWL CCCCCHHHCCCCHHH	23.67	24719451
287	Ubiquitination	YRSFELAKNRDPEKE EEEEEHHHCCCHHHC	66.20	-
301	Phosphorylation	EGSSAFLSAFAVHPV CCCHHHHHHEEEEEC	18.19	-
315	Phosphorylation	VSEGTLMYRLHKRFS CCCCCHHHHHHHHCH	17.09	-
342	N-linked_Glycosylation	QLQAQIRNLTVLTPE HHHHHHHCCEEECCC	41.51	UniProtKB CARBOHYD
467	Phosphorylation	RALARRVSLLRPLSR HHHHHHHHHHCCCCC	21.63	26434776
473	Phosphorylation	VSLLRPLSRVEILPM HHHHCCCCCCEEECC	36.64	26434776
546	Ubiquitination	PDPFLGVKAAAAELE CCCCHHHHHHHHHHH	30.43	-
582	Ubiquitination	RLMDVVSKKHPVDTL EHHHHHCCCCCCCEE	43.42	-
631	Phosphorylation	QEFNPALSPQRSPPG HHCCCCCCCCCCCCC	22.54	24719451
648	O-linked_Glycosylation	GAGPDPPSPPGADPS CCCCCCCCCCCCCCC	49.46	OGP
727	Ubiquitination	VEPGLVQKFSLRDCS CCCCCEEEEECCCCC	29.46	-
729	Phosphorylation	PGLVQKFSLRDCSPR CCCEEEEECCCCCHH	29.54	25394399

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHPF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHPF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHPF2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CHPF2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.