SORT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SORT_MOUSE
• UniProt AC: Q6PHU5
• Protein Name: Sortilin
• Gene Name: Sort1
• Organism: Mus musculus (Mouse).
• Sequence Length: 825
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Golgi apparatus, Golgi stack membrane ; Single-pass type I membrane protein .
• Protein Description: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi..
• Protein Sequence: MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPPLLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANEDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLRKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFTQEPIYFTGLASEPGARSMNISIWGFTESFITRQWVSYTVDFKDILERNCEEDDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSVCPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDKCQGGMNPAREVKDLKKKCTSNFLNPTKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEADGVEALDSTSHAKSGYHDDSDEDLLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	N-linked_Glycosylation	DFIAKLTNNTHQHVF HHHHHHCCCCCCHHC	62.94	-
160	N-linked_Glycosylation	KDITNLINNTFIRTE HHHHHHHHCCEEEEC	44.66	-
199	Phosphorylation	GGRVFRSSDFAKNFV CCEEECCHHHHHHHH	32.27	27149854
272	N-linked_Glycosylation	IFFTTHVNGSCKADL EEEEEEECCCCCCCC	29.11	-
404	N-linked_Glycosylation	GGETDFTNVTSLRGV CCCCCCCCCCCCCEE	34.75	-
580	N-linked_Glycosylation	EPGARSMNISIWGFT CCCCCCCEEEEEEEC	26.54	-
682	N-linked_Glycosylation	FGYFRPENASECVEQ CCCCCCCCHHHHCCC	51.99	-
781	S-palmitoylation	LIVKKYVCGGRFLVH HHHHHCEECCCHHHH	4.31	-
790	Phosphorylation	GRFLVHRYSVLQQHA CCHHHHHHHHHHHHH	6.56	27742792
791	Phosphorylation	RFLVHRYSVLQQHAE CHHHHHHHHHHHHHH	19.13	27742792
807	Phosphorylation	DGVEALDSTSHAKSG CCCEECCCCCCCCCC	32.43	25293948
808	Phosphorylation	GVEALDSTSHAKSGY CCEECCCCCCCCCCC	24.97	25521595
809	Phosphorylation	VEALDSTSHAKSGYH CEECCCCCCCCCCCC	25.96	25338131
812	Ubiquitination	LDSTSHAKSGYHDDS CCCCCCCCCCCCCCC	38.70	-
813	Phosphorylation	DSTSHAKSGYHDDSD CCCCCCCCCCCCCCC	45.42	27087446
815	Phosphorylation	TSHAKSGYHDDSDED CCCCCCCCCCCCCHH	14.79	26239621
819	Phosphorylation	KSGYHDDSDEDLLE- CCCCCCCCCHHHCC-	49.29	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SORT_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
819	S	Phosphorylation	Phosphorylation at Ser-819 facilitates the interaction with GGA1.	17242355

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SORT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SORT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-819, AND MASSSPECTROMETRY.
PubMed: 17203969