EXOC5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOC5_MOUSE
• UniProt AC: Q3TPX4
• Protein Name: Exocyst complex component 5
• Gene Name: Exoc5
• Organism: Mus musculus (Mouse).
• Sequence Length: 708
• Subcellular Localization: Cytoplasm . Midbody . Localization at the midbody requires the presence of RALA, EXOC2 and EXOC3.
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
• Protein Sequence: MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADVIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEVSRMREVAAVLLHFKGYSHCIDVYIKQCQEGAYLRNDIFEDAAILCQRVNKQVGDIFSNPEAVLAKLIQSVFEIKLQSFVKDQLEECRKSDAEQYLKSLYDLYTRTTGLSSKLMEFNLGTDKQTFLSKLIKSIFISYLENYIEVEIGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQYTNACVKVCVYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYSCMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYRSARLARHFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATTAELFE ------CCCHHHHHC	17.41	-
122	Phosphorylation	DQLEGVNTPRQRAVE HHCCCCCCHHHHHHH	19.90	25521595
378	Phosphorylation	SKNHQKRSIGTGGIQ CCCCCCCCCCCCCHH	32.19	25338131
395	Phosphorylation	KERIRQRTNLPLGPS HHHHHHHCCCCCCCC	32.54	-
405	Phosphorylation	PLGPSIDTHGETFLS CCCCCCCCCCCCCCC	30.06	-
412	Phosphorylation	THGETFLSQEVVVNL CCCCCCCCHHHHHHH	21.80	-
437	Phosphorylation	CHRLSDPSDLPRNAF HHHCCCHHHCCHHHH	57.69	25777480
520	Acetylation	KLSECLQKKKEIIEQ HHHHHHHHHHHHHHH	53.52	23576753
521	Acetylation	LSECLQKKKEIIEQM HHHHHHHHHHHHHHH	42.55	23576753
522	Acetylation	SECLQKKKEIIEQME HHHHHHHHHHHHHHH	62.27	23576753
589	Acetylation	YVRKQVEKIKNSMDG HHHHHHHHHHHCCCC	61.19	6569791
591	Acetylation	RKQVEKIKNSMDGKN HHHHHHHHHCCCCCC	54.78	6569503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOC5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOC5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOC5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOC5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.