ANR17_MOUSE - dbPTM
ANR17_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANR17_MOUSE
UniProt AC Q99NH0
Protein Name Ankyrin repeat domain-containing protein 17
Gene Name Ankrd17
Organism Mus musculus (Mouse).
Sequence Length 2603
Subcellular Localization Cytoplasm . Nucleus . Detected around the nucleolus.
Protein Description Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system. [PubMed: 19619540]
Protein Sequence MEKATVPAAAEGEGSPPAAAAVAAPPAAAAAEVGGGARPASSPRGMVRVCDLLLKKKPPQQQQQQQPPHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLAAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANLAATLPVRSKAASKQKSNSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLFTSVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQALPLATGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASVSQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGKGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQATADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEEEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSNNHASAVVTTTMASKKQPSVLVTFPKEERKSVSGKASIKLSETVNEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGPKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIRECTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSTANSKIGSSAPTTTAANSSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTASSSASAVPGTTSNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNSTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKGASASEQEASSPPVVEPANSRPPHSSSSSGSSSGHSTQQQPPGSVPQEPRPPLQQSQVPSPDVRMTVPPTATSSAPVAVPSTAPVTYPMPQTQMGCSQPPKMEAPAIRPPSHATAAPHKTPAPVQSSSASVLNVNHIKRPHSVPSSVQLPSTLSTQSACQNSVHPANKPVAPNFSAPLPFGPFSTLFENNPTNAHAFWGGPVVSSQSTPESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDTPYGSVTPSSTHLGNFASSLSGGQMYGPGAPLGGAPLGGAPTAANFNRQHFSPLSLLTPCSSASNESPAQSVSSGVRAPSPAPSSVPLGSEKPSSVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGSMPFSVYGNAMLPPVAPIADGAGGPIFNGPHSAEPSWNSLIKMVSSSTENNGPQTVWTGPWAPHMNSVHMNQLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEKATVPA
-------CCCCCCCC		48.78-
5Phosphorylation---MEKATVPAAAEG
---CCCCCCCCHHCC		37.7822942356
15PhosphorylationAAAEGEGSPPAAAAV
CHHCCCCCCCHHHHH		24.3326824392
41PhosphorylationGGGARPASSPRGMVR
CCCCCCCCCCCHHHH		43.4925521595
42PhosphorylationGGARPASSPRGMVRV
CCCCCCCCCCHHHHH		22.2623684622
126PhosphorylationDDEEEEVSEVESFIL
CCHHHHHHHHHHHHC		38.92-
130PhosphorylationEEVSEVESFILDQDD
HHHHHHHHHHCCHHH		23.82-
152PhosphorylationTASKLLLSGTADGAD
HHHHHHHHCCCCCCC		33.7854887109
201PhosphorylationPEVLRRLTSSVSCAL
HHHHHHHHHHHHHHH		19.6923984901
202PhosphorylationEVLRRLTSSVSCALD
HHHHHHHHHHHHHHH		33.0825159016
203PhosphorylationVLRRLTSSVSCALDE
HHHHHHHHHHHHHHH		16.8925159016
205PhosphorylationRRLTSSVSCALDEAA
HHHHHHHHHHHHHHH		8.8125159016
216PhosphorylationDEAAAALTRMRAEST
HHHHHHHHHHHHHHH		20.0725159016
222PhosphorylationLTRMRAESTANAGQS
HHHHHHHHHCCCCCC		31.66118587
223PhosphorylationTRMRAESTANAGQSD
HHHHHHHHCCCCCCC		18.5522345495
488PhosphorylationLLIERGASLEEVNDE
HHHHCCCCHHHHCCC		38.8530635358
728PhosphorylationAAPPPDVTQLTPPSH
CCCCCCCCCCCCCCC		25.8226643407
731PhosphorylationPPDVTQLTPPSHDLN
CCCCCCCCCCCCCCC		24.2826643407
734PhosphorylationVTQLTPPSHDLNRAP
CCCCCCCCCCCCCCC		30.7326643407
780PhosphorylationKAASKQKSNSHLPAN
HHHHCCCCCCCCCCC		40.8626643407
782PhosphorylationASKQKSNSHLPANSQ
HHCCCCCCCCCCCCH		33.2326643407
788PhosphorylationNSHLPANSQDVQGYI
CCCCCCCCHHHCHHH		29.8426643407
794PhosphorylationNSQDVQGYITNQSPE
CCHHHCHHHHCCCHH		6.3626643407
796PhosphorylationQDVQGYITNQSPESI
HHHCHHHHCCCHHHH		20.7926643407
799PhosphorylationQGYITNQSPESIVEE
CHHHHCCCHHHHHHH		32.4826643407
802PhosphorylationITNQSPESIVEEAQG
HHCCCHHHHHHHHCH		35.0126643407
830PhosphorylationEKNAQLQSLELAHAD
HHHHHHHHHHHHHHH		32.19-
1188PhosphorylationTPLSLAASGGYVNII
CCHHHHHCCCCHHHH		27.4351460013
1412PhosphorylationVNQFPSDSECMRYIA
HHCCCCHHHHHHHHH		36.7114463171
1453PhosphorylationAEANKNASILLEELD
HHHHHCHHHHHHHCC		24.1423984901
1557PhosphorylationSHGKRNNTITTTSSK
CCCCCCCCEECCCHH		24.2129550500
1562PhosphorylationNNTITTTSSKRKNRK
CCCEECCCHHCCCCC		31.6029514104
1563PhosphorylationNTITTTSSKRKNRKN
CCEECCCHHCCCCCC		34.0929899451
1566AcetylationTTTSSKRKNRKNKIT
ECCCHHCCCCCCCCC		65.917923351
1573PhosphorylationKNRKNKITPENVQII
CCCCCCCCHHCEEEE		26.59-
1601PhosphorylationKVNGESKSSSTSESG
CCCCCCCCCCCCCCC		38.5129895711
1603PhosphorylationNGESKSSSTSESGDS
CCCCCCCCCCCCCCC		42.9429895711
1604PhosphorylationGESKSSSTSESGDSD
CCCCCCCCCCCCCCC		38.1629895711
1605PhosphorylationESKSSSTSESGDSDN
CCCCCCCCCCCCCCC		31.5429895711
1607PhosphorylationKSSSTSESGDSDNMR
CCCCCCCCCCCCCCE		47.9029895711
1616PhosphorylationDSDNMRISSCSDESS
CCCCCEEECCCCCCC		18.2223684622
1617PhosphorylationSDNMRISSCSDESSN
CCCCEEECCCCCCCC		18.4423684622
1619PhosphorylationNMRISSCSDESSNSN
CCEEECCCCCCCCCC		46.4950565435
1631PhosphorylationNSNSSRKSNNHASAV
CCCCCCCCCCCCCEE		41.5814206459
1636PhosphorylationRKSNNHASAVVTTTM
CCCCCCCCEEEEECC		17.6625619855
1640PhosphorylationNHASAVVTTTMASKK
CCCCEEEEECCCCCC		15.2225619855
1642PhosphorylationASAVVTTTMASKKQP
CCEEEEECCCCCCCC		11.0225619855
1668PhosphorylationKSVSGKASIKLSETV
CCCCCCCEEEEECCC		24.6067054351
1679PhosphorylationSETVNEGTSNSLSTC
ECCCCCCCCCCCCCC		20.68-
1689PhosphorylationSLSTCTKSGPSPLSS
CCCCCCCCCCCCCCC		37.4727087446
1692PhosphorylationTCTKSGPSPLSSPNG
CCCCCCCCCCCCCCC		41.8327087446
1695PhosphorylationKSGPSPLSSPNGKLT
CCCCCCCCCCCCCEE		47.3227087446
1696PhosphorylationSGPSPLSSPNGKLTV
CCCCCCCCCCCCEEE		30.0227087446
1702PhosphorylationSSPNGKLTVASPKRG
CCCCCCEEECCCCCC		19.9422345495
1705PhosphorylationNGKLTVASPKRGPKR
CCCEEECCCCCCCCH		26.9822942356
1734PhosphorylationSVPSTVISRVIGRGG
CCCHHHHHHHHCCCC		19.0319367708
1739MethylationVISRVIGRGGCNINA
HHHHHHCCCCCCHHH		27.49-
1821O-linked_GlycosylationIGSSAPTTTAANSSL
CCCCCCCCHHCCHHH		17.2430059200
1822O-linked_GlycosylationGSSAPTTTAANSSLM
CCCCCCCHHCCHHHC		26.6730059200
1834O-linked_GlycosylationSLMGIKMTTVALSST
HHCCCEEEEEEECCC		17.0830059200
1870Asymmetric dimethylarginineKNPVNNVRPGFPVSL
CCCCCCCCCCCCCCC		27.96-
1870MethylationKNPVNNVRPGFPVSL
CCCCCCCCCCCCCCC		27.9624129315
1934PhosphorylationPLSPARATNSPKPHM
CCCCCCCCCCCCCCC		30.5825266776
1936PhosphorylationSPARATNSPKPHMVP
CCCCCCCCCCCCCCC		29.9135098051
1997O-linked_GlycosylationVRRQLFVTVVKTSNA
HHHEEEEEEEECCCC		16.5530059200
2034PhosphorylationMPTAKEHYPVSSPSS
CCCCHHCCCCCCCCC		13.3525168779
2037PhosphorylationAKEHYPVSSPSSPSP
CHHCCCCCCCCCCCC		31.8427087446
2038PhosphorylationKEHYPVSSPSSPSPP
HHCCCCCCCCCCCCC		29.0927087446
2040PhosphorylationHYPVSSPSSPSPPAQ
CCCCCCCCCCCCCCC		57.7527087446
2041PhosphorylationYPVSSPSSPSPPAQP
CCCCCCCCCCCCCCC		32.5525521595
2043PhosphorylationVSSPSSPSPPAQPGG
CCCCCCCCCCCCCCC		45.5227087446
2052PhosphorylationPAQPGGVSRNSPLDC
CCCCCCCCCCCCCCC		29.0827742792
2055PhosphorylationPGGVSRNSPLDCGSA
CCCCCCCCCCCCCCC		26.2325521595
2061PhosphorylationNSPLDCGSASPNKGA
CCCCCCCCCCCCCCC		31.7221082442
2063PhosphorylationPLDCGSASPNKGASA
CCCCCCCCCCCCCCH		30.6125521595
2186O-linked_GlycosylationATAAPHKTPAPVQSS
CCCCCCCCCCCCCCC		22.9630059200
2193O-linked_GlycosylationTPAPVQSSSASVLNV
CCCCCCCCCCCEECC		16.9155410879
2373PhosphorylationNFNRQHFSPLSLLTP
CCCCCCCCCHHHEEC		23.8661948969
2376PhosphorylationRQHFSPLSLLTPCSS
CCCCCCHHHEECCCC		25.3926643407
2379PhosphorylationFSPLSLLTPCSSASN
CCCHHHEECCCCCCC		27.7826643407
2382O-linked_GlycosylationLSLLTPCSSASNESP
HHHEECCCCCCCCCC		30.0930059200
2382PhosphorylationLSLLTPCSSASNESP
HHHEECCCCCCCCCC		30.0926643407
2383PhosphorylationSLLTPCSSASNESPA
HHEECCCCCCCCCCC		42.2926643407
2388O-linked_GlycosylationCSSASNESPAQSVSS
CCCCCCCCCCCCCCC		29.7730059200
2401PhosphorylationSSGVRAPSPAPSSVP
CCCCCCCCCCCCCCC		32.4811165478
2405PhosphorylationRAPSPAPSSVPLGSE
CCCCCCCCCCCCCCC		46.1825168779
2406PhosphorylationAPSPAPSSVPLGSEK
CCCCCCCCCCCCCCC		27.0527742792
2411PhosphorylationPSSVPLGSEKPSSVS
CCCCCCCCCCCCCCC		50.5625619855
2415PhosphorylationPLGSEKPSSVSQDRK
CCCCCCCCCCCCCCC		55.2125619855
2416PhosphorylationLGSEKPSSVSQDRKV
CCCCCCCCCCCCCCC		34.0225619855
2418PhosphorylationSEKPSSVSQDRKVPV
CCCCCCCCCCCCCCC		28.4525619855
2489PhosphorylationPMIHRPMSDPGVFSQ
CCCCCCCCCCCCCCH		43.2530850165
2509PhosphorylationRDSTGIVTPSGTFHQ
CCCCCEECCCCCCCC		15.1515994051
2527UbiquitinationAGYMDFPKVGSMPFS
CCCCCCCCCCCCCCE		60.26-
2530PhosphorylationMDFPKVGSMPFSVYG
CCCCCCCCCCCEEEC		26.6951460021
2534PhosphorylationKVGSMPFSVYGNAML
CCCCCCCEEECCCCC		14.4625777480
2536PhosphorylationGSMPFSVYGNAMLPP
CCCCCEEECCCCCCC		11.9425777480
2561PhosphorylationPIFNGPHSAEPSWNS
CCCCCCCCCCCCHHH		37.1425777480
2565PhosphorylationGPHSAEPSWNSLIKM
CCCCCCCCHHHHHHH		30.3225777480
2568PhosphorylationSAEPSWNSLIKMVSS
CCCCCHHHHHHHHHC		25.8025777480
2574PhosphorylationNSLIKMVSSSTENNG
HHHHHHHHCCCCCCC		18.3129895711
2575PhosphorylationSLIKMVSSSTENNGP
HHHHHHHCCCCCCCC		29.8429895711
2596PhosphorylationPWAPHMNSVHMNQLG
CCCCCCCCCCHHCCC		13.0629895711
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANR17_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANR17_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANR17_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ANR17_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANR17_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2401, AND MASSSPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2040, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1631, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2043, AND MASSSPECTROMETRY.

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