TCPG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPG_MOUSE
• UniProt AC: P80318
• Protein Name: T-complex protein 1 subunit gamma
• Gene Name: Cct3
• Organism: Mus musculus (Mouse).
• Sequence Length: 545
• Subcellular Localization: Cytoplasm.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Plays a role in the assembly of the von Hippel-Lindau ubiquitination complex (By similarity). Interacts with DNAAF4..
• Protein Sequence: MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMGHRPVL -------CCCCCCEE	7.01	-
11	Phosphorylation	HRPVLVLSQNTKRES CCCEEEEECCCCCCC	17.57	-
24	Phosphorylation	ESGRKVQSGNINAAK CCCCCCCCCCCCHHH	36.47	29514104
31	Ubiquitination	SGNINAAKTIADIIR CCCCCHHHHHHHHHH	37.75	22790023
44	Ubiquitination	IRTCLGPKSMMKMLL HHHHHCHHHHHHHHH	49.54	22790023
60	Phosphorylation	PMGGIVMTNDGNAIL CCCCEEEECCCCHHH	21.18	22817900
138	Ubiquitination	DDMISTLKKISTPVD HHHHHHHHHCCCCCC	48.42	-
138	Acetylation	DDMISTLKKISTPVD HHHHHHHHHCCCCCC	48.42	23806337
138	Succinylation	DDMISTLKKISTPVD HHHHHHHHHCCCCCC	48.42	23806337
139	Ubiquitination	DMISTLKKISTPVDV HHHHHHHHCCCCCCC	45.03	22790023
170	Phosphorylation	KVISRWSSLACNIAL HHHHHHHHHHHHHHH	17.02	22817900
173	S-nitrosylation	SRWSSLACNIALDAV HHHHHHHHHHHHHHH	4.61	20925432
173	S-nitrosocysteine	SRWSSLACNIALDAV HHHHHHHHHHHHHHH	4.61	-
173	S-palmitoylation	SRWSSLACNIALDAV HHHHHHHHHHHHHHH	4.61	28526873
173	Glutathionylation	SRWSSLACNIALDAV HHHHHHHHHHHHHHH	4.61	24333276
203	Acetylation	KKYARVEKIPGGIIE HHEEEEEECCCCCCC	51.88	22826441
213	S-nitrosylation	GGIIEDSCVLRGVMI CCCCCCCCEEECEEE	5.31	24926564
213	S-nitrosocysteine	GGIIEDSCVLRGVMI CCCCCCCCEEECEEE	5.31	-
213	Glutathionylation	GGIIEDSCVLRGVMI CCCCCCCCEEECEEE	5.31	24333276
222	Malonylation	LRGVMINKDVTHPRM EECEEECCCCCCHHH	42.52	26320211
222	Acetylation	LRGVMINKDVTHPRM EECEEECCCCCCHHH	42.52	23236377
232	Phosphorylation	THPRMRRYIKNPRIV CCHHHHHHCCCCCEE	13.09	-
243	Phosphorylation	PRIVLLDSSLEYKKG CCEEEEECCCCCCCC	36.47	30352176
244	Phosphorylation	RIVLLDSSLEYKKGE CEEEEECCCCCCCCC	25.53	30352176
247	Phosphorylation	LLDSSLEYKKGESQT EEECCCCCCCCCCCC	24.24	-
248	Acetylation	LDSSLEYKKGESQTD EECCCCCCCCCCCCC	44.95	23236377
248	Malonylation	LDSSLEYKKGESQTD EECCCCCCCCCCCCC	44.95	26320211
248	Ubiquitination	LDSSLEYKKGESQTD EECCCCCCCCCCCCC	44.95	-
249	Ubiquitination	DSSLEYKKGESQTDI ECCCCCCCCCCCCCC	67.99	22790023
252	Phosphorylation	LEYKKGESQTDIEIT CCCCCCCCCCCCEEE	47.23	26824392
254	Phosphorylation	YKKGESQTDIEITRE CCCCCCCCCCEEECH	48.50	26239621
259	Phosphorylation	SQTDIEITREEDFTR CCCCCEEECHHHHHH	21.16	23684622
333	Phosphorylation	ACGARIVSRPEELRE HHCCEEECCHHHHCC	39.48	22006019
366	Glutathionylation	YFTFITDCKDPKACT EEEEEECCCCHHHHE	3.94	24333276
367	Ubiquitination	FTFITDCKDPKACTI EEEEECCCCHHHHEE	78.76	-
370	Acetylation	ITDCKDPKACTILLR EECCCCHHHHEEEEC	67.25	7844341
372	Glutathionylation	DCKDPKACTILLRGA CCCCHHHHEEEECCC	2.80	24333276
372	S-nitrosylation	DCKDPKACTILLRGA CCCCHHHHEEEECCC	2.80	21278135
372	S-nitrosocysteine	DCKDPKACTILLRGA CCCCHHHHEEEECCC	2.80	-
380	Phosphorylation	TILLRGASKEILSEV EEEECCCCHHHHHHH	33.38	28066266
381	Ubiquitination	ILLRGASKEILSEVE EEECCCCHHHHHHHH	48.52	-
381	Acetylation	ILLRGASKEILSEVE EEECCCCHHHHHHHH	48.52	23806337
381	Malonylation	ILLRGASKEILSEVE EEECCCCHHHHHHHH	48.52	26320211
385	Phosphorylation	GASKEILSEVERNLQ CCCHHHHHHHHHHHH	45.30	30352176
398	S-nitrosylation	LQDAMQVCRNVLLDP HHHHHHHHHHHHCCC	1.15	21278135
398	S-palmitoylation	LQDAMQVCRNVLLDP HHHHHHHHHHHHCCC	1.15	28526873
398	S-nitrosocysteine	LQDAMQVCRNVLLDP HHHHHHHHHHHHCCC	1.15	-
398	Glutathionylation	LQDAMQVCRNVLLDP HHHHHHHHHHHHCCC	1.15	24333276
425	Ubiquitination	VAHALTEKSKAMTGV HHHHHHHHCCCCCCC	52.61	22790023
430	Phosphorylation	TEKSKAMTGVEQWPY HHHCCCCCCCCCCHH	42.82	-
450	Phosphorylation	ALEVIPRTLIQNCGA HHHHCCHHHHHHCCH	23.90	25777480
455	Glutathionylation	PRTLIQNCGASTIRL CHHHHHHCCHHHHHH	2.49	24333276
455	S-palmitoylation	PRTLIQNCGASTIRL CHHHHHHCCHHHHHH	2.49	28526873
455	S-nitrosocysteine	PRTLIQNCGASTIRL CHHHHHHCCHHHHHH	2.49	-
455	S-nitrosylation	PRTLIQNCGASTIRL CHHHHHHCCHHHHHH	2.49	20925432
458	Phosphorylation	LIQNCGASTIRLLTS HHHHCCHHHHHHHHH	15.06	22006019
459	Phosphorylation	IQNCGASTIRLLTSL HHHCCHHHHHHHHHH	15.02	28066266
465	Phosphorylation	STIRLLTSLRAKHTQ HHHHHHHHHHHHCCH	18.81	22006019
475	S-nitrosylation	AKHTQESCETWGVNG HHCCHHHHHHCCCCC	5.48	20925432
475	Glutathionylation	AKHTQESCETWGVNG HHCCHHHHHHCCCCC	5.48	24333276
475	S-nitrosocysteine	AKHTQESCETWGVNG HHCCHHHHHHCCCCC	5.48	-
507	Ubiquitination	AVKLQTYKTAVETAV HHHHHHHHHHHHHHH	33.14	22790023
507	Acetylation	AVKLQTYKTAVETAV HHHHHHHHHHHHHHH	33.14	22826441
524	Phosphorylation	LRIDDIVSGHKKKGD HHHHHHHCCCCCCCC	35.20	27180971
527	Ubiquitination	DDIVSGHKKKGDDQN HHHHCCCCCCCCCCC	60.76	22790023
529	Ubiquitination	IVSGHKKKGDDQNRQ HHCCCCCCCCCCCCC	72.82	22790023
537	Phosphorylation	GDDQNRQTGAPDAGQ CCCCCCCCCCCCCCC	31.88	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPG_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPB_MOUSE	Cct2	physical	9250675
PDCL3_HUMAN	PDCL3	physical	20360068
MEP50_HUMAN	WDR77	physical	20360068
PDCD5_HUMAN	PDCD5	physical	20360068
IGBP1_HUMAN	IGBP1	physical	20360068
TCPZ_HUMAN	CCT6A	physical	26496610
EF2_HUMAN	EEF2	physical	26496610
GBB2_HUMAN	GNB2	physical	26496610
HDAC2_HUMAN	HDAC2	physical	26496610
TNPO1_HUMAN	TNPO1	physical	26496610
PHLP_HUMAN	PDCL	physical	26496610
PFD1_HUMAN	PFDN1	physical	26496610
PFD2_HUMAN	PFDN2	physical	26496610
PEPL_HUMAN	PPL	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TLE3_HUMAN	TLE3	physical	26496610
TBB2A_HUMAN	TUBB2A	physical	26496610
XPO1_HUMAN	XPO1	physical	26496610
PDCD5_HUMAN	PDCD5	physical	26496610
PDCD6_HUMAN	PDCD6	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
TXND9_HUMAN	TXNDC9	physical	26496610
TBA1B_HUMAN	TUBA1B	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
HGH1_HUMAN	HGH1	physical	26496610
MRRP1_HUMAN	TRMT10C	physical	26496610
S35F6_HUMAN	SLC35F6	physical	26496610
LST8_HUMAN	MLST8	physical	26496610
AIDA_HUMAN	AIDA	physical	26496610
PDCL3_HUMAN	PDCL3	physical	26496610
MEP50_HUMAN	WDR77	physical	26496610
S35E1_HUMAN	SLC35E1	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610
RRF2M_HUMAN	GFM2	physical	26496610
RUSD4_HUMAN	RPUSD4	physical	26496610
HACD2_HUMAN	PTPLB	physical	26496610
TBB5_HUMAN	TUBB	physical	26496610
FMN1_HUMAN	FMN1	physical	26496610
WDR92_HUMAN	WDR92	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.