CDC45_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC45_MOUSE
• UniProt AC: Q9Z1X9
• Protein Name: Cell division control protein 45 homolog
• Gene Name: Cdc45
• Organism: Mus musculus (Mouse).
• Sequence Length: 566
• Subcellular Localization: Nucleus.
• Protein Description: Required for initiation of chromosomal DNA replication..
• Protein Sequence: MFVTDFRKEFYETVHNQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAYLEHKEQFSYFILINCGANVDLLDILQPDEDSIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRDEAEDEDLSDSDGDGSEPSEKRTRLEEEIVERNRKRRQRREWEARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDVSLKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGTPDVTLFSKPASLSLLSRHLLKSFVYSTKNRRCKLLPLVMAAPLSVEQGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRTLHNYFDLSVIELKAEDRSKFLDALVSLLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	RVLLFVASDVDALCA EEEEEEECCHHHHHH	32.63	20139300
110	Phosphorylation	PVNVVNVYNDTQIKL CEEEEEEECCCCEEE	11.34	29895711
113	Phosphorylation	VVNVYNDTQIKLLIK EEEEECCCCEEEEEE	28.67	29895711
130	Phosphorylation	DDLEVPAYDDIFRDE CCCCCCCCCHHCCCC	14.21	-
144	Phosphorylation	EAEDEDLSDSDGDGS CCCCCCCCCCCCCCC	47.60	21149613
146	Phosphorylation	EDEDLSDSDGDGSEP CCCCCCCCCCCCCCC	39.87	21149613
151	Phosphorylation	SDSDGDGSEPSEKRT CCCCCCCCCCCHHHH	51.58	21149613
380	Phosphorylation	ASDVVFATMSLMESP HHHHEEEEHHHHCCC	8.88	25367039
382	Phosphorylation	DVVFATMSLMESPEK HHEEEEHHHHCCCCC	21.88	25367039
386	Phosphorylation	ATMSLMESPEKDGSG EEHHHHCCCCCCCCC	25.13	25367039
465	Phosphorylation	TLFSKPASLSLLSRH EEECCCHHHHHHHHH	27.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC45_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC45_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC45_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CDC45_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.