| UniProt ID | IF122_MOUSE | |
|---|---|---|
| UniProt AC | Q6NWV3 | |
| Protein Name | Intraflagellar transport protein 122 homolog | |
| Gene Name | Ift122 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1182 | |
| Subcellular Localization | Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Localizes to photoreceptor connecting cilia. | |
| Protein Description | Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia.. | |
| Protein Sequence | MRAVLTWRDKAEQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPEQKSVSKHKSSSKITCCSWTNDGQYLALGMANGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREEHNDILAVADWGQKLSFYQLSGKQIGKDRPLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCRVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCRELVKKIAIYKNRLAIQLPEKILIYELYSEDSTDMHYRVKEKIVKKFECNLLVVCADHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHQQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFKEAYQIACLGVTDADWRELAMEALEGLEFETARKAFTRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALDMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNINEPKAAVEMYISAGEHAKAIEISGSHGWVDMLIDIARKLDKAEREPLLMCACYFKKLDSPGYAAETYLKIGDLKSLVQLYVDTKRWDEAFALGEKHPEFKDDVYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLDMAQDPAQKDAMLDKFHHFQHLAELYHGYQTIHRYTEEPFSFDLPETLFNISKFLLHSLTKATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLRGLQIPARIQKSIELGTLTIRSKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYEVLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWRETSSNNSQTLKLDETMDSIGEDDPFTAKLSFEQGSSEFVPVVVNRSVLRSMSRRDVLIKRWPPPLQWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHACCPYCRRRIDDTGP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 212 | Ubiquitination | SFYQLSGKQIGKDRP EEEECCCCCCCCCCC | 35.05 | - | |
| 667 | Phosphorylation | ENLALDMYTDLCMFE CCHHHHHHHHHHHHH | 9.21 | - | |
| 668 | Phosphorylation | NLALDMYTDLCMFEY CHHHHHHHHHHHHHH | 18.83 | - | |
| 694 | Ubiquitination | ETKMLITKQADWARN HCEEEEHHHHHHHHH | 36.17 | - | |
| 761 | Phosphorylation | CYFKKLDSPGYAAET HEEECCCCCCCCCCE | 30.57 | 25293948 | |
| 942 | Phosphorylation | SKVNTLFTLAKQSKA HHHHHHHHHHHHHHH | 28.99 | 22006019 | |
| 974 | Ubiquitination | QIPARIQKSIELGTL CCCHHHHCCEECCCE | 51.54 | - | |
| 980 | Phosphorylation | QKSIELGTLTIRSKP HCCEECCCEEEECCC | 33.09 | 28066266 | |
| 982 | Phosphorylation | SIELGTLTIRSKPFH CEECCCEEEECCCCC | 17.74 | 28066266 | |
| 1069 | Phosphorylation | EGKWRETSSNNSQTL CCCCEECCCCCCCEE | 26.73 | 25338131 | |
| 1070 | Phosphorylation | GKWRETSSNNSQTLK CCCEECCCCCCCEEE | 47.66 | 25338131 | |
| 1084 | Phosphorylation | KLDETMDSIGEDDPF EECHHHHCCCCCCCC | 22.98 | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IF122_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IF122_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IF122_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IF122_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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