PSME4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSME4_MOUSE
• UniProt AC: Q5SSW2
• Protein Name: Proteasome activator complex subunit 4
• Gene Name: Psme4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1843
• Subcellular Localization: Cytoplasm, cytosol. Nucleus. Nucleus speckle. Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2)..
• Protein Description: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks..
• Protein Sequence: MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDLVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADSTAEMLEEWRPLMCPFDVTMQKAISYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPVKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELIKLQCCGDGELEMSRDDILQSLTIVHSCLIGSGNLLPPLKGEAVTNLVPSMVSLEETKLYTGLEHDLSRENYREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLHFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADALRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPTKILAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMIEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIICLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Ubiquitination	DLQLAQIKSNLGRAV HHHHHHHHHHHCHHC	22.63	22790023
146	Phosphorylation	ELPWRPLYDLVERIL CCCCHHHHHHHHHHH	15.20	21454597
157	Phosphorylation	ERILYSKTEHLRLNS HHHHHCCCCCHHCCC	23.77	21454597
178	Malonylation	NVLKTLVKSCRPYFP HHHHHHHHHCCCCCC	47.12	26320211
286	Phosphorylation	IFTRILRSLNLPVGS HHHHHHHHCCCCCCC	20.40	21454597
293	Phosphorylation	SLNLPVGSSQVLVPR HCCCCCCCCCCHHHH	20.17	25293948
294	Phosphorylation	LNLPVGSSQVLVPRF CCCCCCCCCCHHHHH	20.55	25293948
355	Acetylation	RWLNKLMKLLQRLPN HHHHHHHHHHHHCCH	57.38	22826441
727	Phosphorylation	LLHHLLRSTTLIYPT HHHHHHHHCCEEECC	26.22	-
728	Phosphorylation	LHHLLRSTTLIYPTE HHHHHHHCCEEECCC	21.13	-
729	Phosphorylation	HHLLRSTTLIYPTEY HHHHHHCCEEECCCC	16.65	-
852	Phosphorylation	SLEETKLYTGLEHDL CHHHHCHHCCCCCCC	10.58	25159016
853	Phosphorylation	LEETKLYTGLEHDLS HHHHCHHCCCCCCCC	45.81	25159016
916	Ubiquitination	HEFDSRWKSFNLVKK CCCCHHHHHHHHHHH	44.02	22790023
1082	Ubiquitination	LFDDLAEKIHRQYET HHHHHHHHHHHHHHH	37.90	22790023
1114	Phosphorylation	LQQSKNPSISQTLLS HHHCCCCCHHHHCCC	44.24	25777480
1116	Phosphorylation	QSKNPSISQTLLSPE HCCCCCHHHHCCCHH	22.81	25777480
1118	Phosphorylation	KNPSISQTLLSPEKI CCCCHHHHCCCHHHH	23.91	23984901
1121	Phosphorylation	SISQTLLSPEKIKEG CHHHHCCCHHHHHHH	33.84	21149613
1124	Ubiquitination	QTLLSPEKIKEGQKR HHCCCHHHHHHHHHH	63.56	22790023
1294	Ubiquitination	AGVEEQPKLGRSRED EECCCCCCCCCCHHH	64.37	22790023
1343	S-nitrosylation	KFSPRRFCLFKGIFR CCCHHHHHHHHHHHC	4.07	21278135
1343	S-nitrosocysteine	KFSPRRFCLFKGIFR CCCHHHHHHHHHHHC	4.07	-
1346	Acetylation	PRRFCLFKGIFRNFD HHHHHHHHHHHCCCC	37.84	22826441
1361	Ubiquitination	DAFLPVLKPHLERLV CCHHHHHHHHHHHHH	30.53	22790023
1488	Ubiquitination	ELLHRLLKYLEPKLT HHHHHHHHHHCHHHH	53.00	22790023
1488	Acetylation	ELLHRLLKYLEPKLT HHHHHHHHHHCHHHH	53.00	22826441
1499	Ubiquitination	PKLTQVYKNVRERIG HHHHHHHHHHHHHHH	50.54	22790023
1499	Acetylation	PKLTQVYKNVRERIG HHHHHHHHHHHHHHH	50.54	23954790
1507	Phosphorylation	NVRERIGSVLTYIFM HHHHHHHHHHHHEEE	16.16	28059163
1510	Phosphorylation	ERIGSVLTYIFMIDV HHHHHHHHHEEEEEC	16.65	28059163
1594	Ubiquitination	RSFSTAVKEQLQLLP CCHHHHHHHHHHHHH	36.96	-
1614	Phosphorylation	APVENDNSYDELKRD CCCCCCCCHHHHHHH	36.50	-
1746	Phosphorylation	KRKRDPGSVGDTIPS CCCCCCCCCCCCCCH	28.45	21743459

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSME4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSME4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSME4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSME4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.