PSA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA5_MOUSE
• UniProt AC: Q9Z2U1
• Protein Name: Proteasome subunit alpha type-5
• Gene Name: Psma5
• Organism: Mus musculus (Mouse).
• Sequence Length: 241
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFLTRSEY -------CCCCHHHC	5.84	16857966
14	Phosphorylation	EYDRGVNTFSPEGRL HCCCCCCCCCCCCCE	24.08	28833060
16	Phosphorylation	DRGVNTFSPEGRLFQ CCCCCCCCCCCCEEE	21.72	26824392
26	Phosphorylation	GRLFQVEYAIEAIKL CCEEEHHHHHHHHHC	17.64	25159016
55	Phosphorylation	LAVEKRITSPLMEPS EEEEECCCCCCCCCC	28.46	25521595
56	Phosphorylation	AVEKRITSPLMEPSS EEEECCCCCCCCCCH	17.42	25521595
62	Phosphorylation	TSPLMEPSSIEKIVE CCCCCCCCHHHHHHE	30.55	28833060
63	Phosphorylation	SPLMEPSSIEKIVEI CCCCCCCHHHHHHEE	45.54	28833060
91	Acetylation	DAKTLIDKARVETQN CHHHHHHHHHHEEEC	30.97	22826441
91	Malonylation	DAKTLIDKARVETQN CHHHHHHHHHHEEEC	30.97	26320211
134	Phosphorylation	DADPGAMSRPFGVAL CCCCCCCCCCCEEEE	35.95	18579562
165	Glutathionylation	PSGTFVQCDARAIGS CCCCEEEECCEEECC	3.57	24333276
187	Ubiquitination	SLQEVYHKSMTLKEA HHHHHHHHCCCHHHH	25.00	-
187	Acetylation	SLQEVYHKSMTLKEA HHHHHHHHCCCHHHH	25.00	22826441
190	Phosphorylation	EVYHKSMTLKEAIKS HHHHHCCCHHHHHHH	41.59	18779572
192	Succinylation	YHKSMTLKEAIKSSL HHHCCCHHHHHHHHH	35.61	23954790
192	Ubiquitination	YHKSMTLKEAIKSSL HHHCCCHHHHHHHHH	35.61	-
196	Ubiquitination	MTLKEAIKSSLIILK CCHHHHHHHHHHHHH	40.83	-
198	O-linked_Glycosylation	LKEAIKSSLIILKQV HHHHHHHHHHHHHHH	20.70	22556278
203	Acetylation	KSSLIILKQVMEEKL HHHHHHHHHHHHHHH	30.36	22826441
213	Phosphorylation	MEEKLNATNIELATV HHHHHCCCCEEEEEE	35.34	26643407
230	Phosphorylation	GQNFHMFTKEELEEV CCCEECEEHHHHHHH	29.94	18579562
239	Acetylation	EELEEVIKDI----- HHHHHHHHCC-----	55.32	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSA5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.