HOOK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOOK2_MOUSE
• UniProt AC: Q7TMK6
• Protein Name: Protein Hook homolog 2
• Gene Name: Hook2
• Organism: Mus musculus (Mouse).
• Sequence Length: 716
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Cytoplasm, cytoskeleton . Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi comple
• Protein Description: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones..
• Protein Sequence: MSVDKAELCGSLLTWLQTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISEDSSPSWRLKVRKLEKILQSLVEYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLGCAISCEKKQEYIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPENYGNFDTQSRRYYFLSEEVEEGDHLQQHYLDLERQLLLLSEEKQNLAQENAALRERVGRSEVESAPGLTAKKLLLLQSQLEQLQEENFRLESSREDDRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQELRRQVRQLEERNAGHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGQWQEEAMKAEKWLFECRNLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAELRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQKALQEQGGKTEDPTLLKRKLEDHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQDSLQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYEKSRRRQEQEEKLLISAWYSMGMALEHRAGEEHAPAHAQSFLAQQRLATNARRGPLGRQALSLRPTDKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
163	Phosphorylation	KDTPDSLSPENYGNF CCCCCCCCCCCCCCC	33.83	22006019
316	Phosphorylation	QLEATLNSCRRRLGE HHHHHHHHHHHHHHH	16.47	30635358
623	Phosphorylation	QRPPTVVSPEFHTLR CCCCCEECCCHHHHH	17.86	29514104
649	Acetylation	QMEMDYEKSRRRQEQ HHHHHHHHHHHHHHH	42.93	19864095

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HOOK2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOOK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOOK2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HOOK2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.