| UniProt ID | BIG2_MOUSE | |
|---|---|---|
| UniProt AC | A2A5R2 | |
| Protein Name | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | |
| Gene Name | Arfgef2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1792 | |
| Subcellular Localization | Cytoplasm. Membrane. Golgi apparatus. Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite. Cytoplasmic vesicle. Cell junction, synapse | |
| Protein Description | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways (By similarity).. | |
| Protein Sequence | MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVSGRAEPSRGTDSGAQEVVKDILEDVVTSAVKEAAEKHGLPEPDRALGALECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYAHQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDAEIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGLVYKIWIPEEPSQVPAALSSTW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MQESQTKS -------CCHHHHHH | - | ||
| 4 | Phosphorylation | ----MQESQTKSMFV ----CCHHHHHHHHH | 26643407 | ||
| 6 | Phosphorylation | --MQESQTKSMFVSR --CCHHHHHHHHHHH | 26643407 | ||
| 8 | Phosphorylation | MQESQTKSMFVSRAL CCHHHHHHHHHHHHH | 26643407 | ||
| 12 | Phosphorylation | QTKSMFVSRALEKIL HHHHHHHHHHHHHHH | 26643407 | ||
| 30 | Phosphorylation | EVKRPQHSQLRRACQ CCCCCCHHHHHHHHH | 25266776 | ||
| 49 | Acetylation | EIKAELEKQRLGAAA HHHHHHHHHCCCCCC | 23201123 | ||
| 107 | Phosphorylation | ITGNAPDSGAPGKRL CCCCCCCCCCCCHHH | - | ||
| 180 | Phosphorylation | SKNLINQTTAKATLT CCCCCCHHHHHHHHH | 29472430 | ||
| 181 | Phosphorylation | KNLINQTTAKATLTQ CCCCCHHHHHHHHHH | 29472430 | ||
| 214 | Phosphorylation | ELEKPMQSKPQSPVI HHCCCCCCCCCCCCC | 27087446 | ||
| 218 | Phosphorylation | PMQSKPQSPVIQATA CCCCCCCCCCCHHCC | 27087446 | ||
| 224 | Phosphorylation | QSPVIQATAGSPKFS CCCCCHHCCCCCCHH | 26824392 | ||
| 227 | Phosphorylation | VIQATAGSPKFSRLK CCHHCCCCCCHHHHH | 27087446 | ||
| 236 | Phosphorylation | KFSRLKQSQAQSKPT CHHHHHHHHHCCCCC | 29899451 | ||
| 240 | Phosphorylation | LKQSQAQSKPTTPEK HHHHHHCCCCCCCCC | 25159016 | ||
| 243 | Phosphorylation | SQAQSKPTTPEKAEL HHHCCCCCCCCCCCC | 25521595 | ||
| 244 | Phosphorylation | QAQSKPTTPEKAELP HHCCCCCCCCCCCCC | 25521595 | ||
| 264 | Phosphorylation | QSGLGKVSLENGEAP CCCCCCEEECCCCCC | 26060331 | ||
| 276 | Phosphorylation | EAPRERGSPVSGRAE CCCHHCCCCCCCCCC | 27087446 | ||
| 279 | Phosphorylation | RERGSPVSGRAEPSR HHCCCCCCCCCCCCC | 25266776 | ||
| 309 | Ubiquitination | DVVTSAVKEAAEKHG HHHHHHHHHHHHHCC | 22790023 | ||
| 335 | Ubiquitination | ECQECAVPPGVDENS CCHHCCCCCCCCCCC | 27667366 | ||
| 342 | Phosphorylation | PPGVDENSQTNGIAD CCCCCCCCCCCCCCC | 23140645 | ||
| 344 | Phosphorylation | GVDENSQTNGIADDR CCCCCCCCCCCCCCH | 23140645 | ||
| 353 | Phosphorylation | GIADDRQSLSSADNL CCCCCHHHHCCHHCC | 25619855 | ||
| 355 | Phosphorylation | ADDRQSLSSADNLEP CCCHHHHCCHHCCCC | 25521595 | ||
| 356 | Phosphorylation | DDRQSLSSADNLEPD CCHHHHCCHHCCCCC | 25521595 | ||
| 468 | Phosphorylation | LSLAIFLTLLSNFKM HHHHHHHHHHHHHHH | - | ||
| 471 | Phosphorylation | AIFLTLLSNFKMHLK HHHHHHHHHHHHHHH | - | ||
| 523 | Ubiquitination | DAQCVVDIYVNYDCD CCCEEEEEEEECCCC | 27667366 | ||
| 537 | Ubiquitination | DLNAANIFERLVNDL CCCHHHHHHHHHHHH | 27667366 | ||
| 545 | Ubiquitination | ERLVNDLSKIAQGRS HHHHHHHHHHHCCCC | 27667366 | ||
| 546 | Ubiquitination | RLVNDLSKIAQGRSG HHHHHHHHHHCCCCC | 27667366 | ||
| 565 | Phosphorylation | MTPLQELSLRKKGLE CCHHHHHHHHHHHHH | 25159016 | ||
| 569 | Ubiquitination | QELSLRKKGLECLVS HHHHHHHHHHHHHHH | 22790023 | ||
| 621 | Phosphorylation | LDMARRCSVTSVEST CCHHHHCEEEEEEEE | 25521595 | ||
| 623 | Phosphorylation | MARRCSVTSVESTVS HHHHCEEEEEEEECC | 27087446 | ||
| 624 | Phosphorylation | ARRCSVTSVESTVSS HHHCEEEEEEEECCC | 27087446 | ||
| 627 | Phosphorylation | CSVTSVESTVSSGTQ CEEEEEEEECCCCCC | 27087446 | ||
| 628 | Phosphorylation | SVTSVESTVSSGTQT EEEEEEEECCCCCCE | 23684622 | ||
| 630 | Phosphorylation | TSVESTVSSGTQTAI EEEEEECCCCCCEEE | 25168779 | ||
| 631 | Phosphorylation | SVESTVSSGTQTAIQ EEEEECCCCCCEEEC | 25168779 | ||
| 633 | Phosphorylation | ESTVSSGTQTAIQDD EEECCCCCCEEECCC | 27087446 | ||
| 635 | Phosphorylation | TVSSGTQTAIQDDPE ECCCCCCEEECCCHH | 27087446 | ||
| 707 | Phosphorylation | VGEFLGDSTRFNKEV HHHHHCCCCCCCHHH | - | ||
| 725 | Ubiquitination | YVDQLDFCEKEFVSA HHHHHHHHHHHHHHH | 27667366 | ||
| 747 | Ubiquitination | FRLPGEAQKIDRLME CCCCCHHHHHHHHHH | 27667366 | ||
| 748 | Ubiquitination | RLPGEAQKIDRLMEK CCCCHHHHHHHHHHH | 27667366 | ||
| 847 | Acetylation | KEHTIATKSTKQSVA HCCEECCCCCCHHHC | 19844805 | ||
| 872 | Ubiquitination | VEMEQMAKTAKALME HHHHHHHHHHHHHHH | 22790023 | ||
| 962 | Phosphorylation | LARFSLLTASSSITE HHHHHHHHCCCCHHH | 28576409 | ||
| 1020 | Phosphorylation | GTGVKTRYLSGSGRE CCCCCCEECCCCCCC | 25521595 | ||
| 1022 | Phosphorylation | GVKTRYLSGSGRERE CCCCEECCCCCCCCC | 22817900 | ||
| 1024 | Phosphorylation | KTRYLSGSGREREGS CCEECCCCCCCCCCC | 28066266 | ||
| 1031 | Phosphorylation | SGREREGSLKGHSLA CCCCCCCCCCCCCCC | 25266776 | ||
| 1036 | Phosphorylation | EGSLKGHSLAGEEFM CCCCCCCCCCCCCCC | 25266776 | ||
| 1178 | Ubiquitination | LSMKFLEKGELANFR HHHHHHHCCCCCCCC | 22790023 | ||
| 1227 | Phosphorylation | SQAANIRSGWKNIFA HHHHHHHHHHHHHHH | - | ||
| 1518 | Phosphorylation | DVDLDRQSLSSIDRN CCCCCHHHHHHHCCC | 25521595 | ||
| 1520 | Phosphorylation | DLDRQSLSSIDRNAS CCCHHHHHHHCCCHH | 26824392 | ||
| 1521 | Phosphorylation | LDRQSLSSIDRNASE CCHHHHHHHCCCHHH | 26824392 | ||
| 1527 | Phosphorylation | SSIDRNASERGQSQL HHHCCCHHHHCCCCC | 25367039 | ||
| 1532 | Phosphorylation | NASERGQSQLSNPTD CHHHHCCCCCCCCCC | 25521595 | ||
| 1535 | Phosphorylation | ERGQSQLSNPTDDSW HHCCCCCCCCCCCCC | 25521595 | ||
| 1538 | Phosphorylation | QSQLSNPTDDSWKGA CCCCCCCCCCCCCCC | 22802335 | ||
| 1541 | Phosphorylation | LSNPTDDSWKGAPYA CCCCCCCCCCCCCHH | 25619855 | ||
| 1789 | Phosphorylation | SQVPAALSSTW---- HHCCHHHCCCC---- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BIG2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BIG2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BIG2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of BIG2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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