TCPZ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPZ_MOUSE
• UniProt AC: P80317
• Protein Name: T-complex protein 1 subunit zeta
• Gene Name: Cct6a
• Organism: Mus musculus (Mouse).
• Sequence Length: 531
• Subcellular Localization: Cytoplasm.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin..
• Protein Sequence: MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIRKKDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALNSFDDLNPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVDLSTGEPMVAAEMGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVKTLNP ------CCCCCCCCH	22.44	23806337
5	Acetylation	---MAAVKTLNPKAE ---CCCCCCCCHHHH	42.44	23806337
6	Phosphorylation	--MAAVKTLNPKAEV --CCCCCCCCHHHHH	25.76	24719451
10	Ubiquitination	AVKTLNPKAEVARAQ CCCCCCHHHHHHHHH	56.98	-
10	Malonylation	AVKTLNPKAEVARAQ CCCCCCHHHHHHHHH	56.98	26320211
127	Ubiquitination	TEGFEAAKEKALQFL HCCHHHHHHHHHHHH	67.79	22790023
127	Acetylation	TEGFEAAKEKALQFL HCCHHHHHHHHHHHH	67.79	23236377
129	Ubiquitination	GFEAAKEKALQFLEQ CHHHHHHHHHHHHHH	54.40	-
129	Acetylation	GFEAAKEKALQFLEQ CHHHHHHHHHHHHHH	54.40	23806337
129	Malonylation	GFEAAKEKALQFLEQ CHHHHHHHHHHHHHH	54.40	26320211
138	Ubiquitination	LQFLEQVKVSKEMDR HHHHHHHCCCCCCCH	40.25	22790023
140	Phosphorylation	FLEQVKVSKEMDRET HHHHHCCCCCCCHHH	19.72	25195567
141	Acetylation	LEQVKVSKEMDRETL HHHHCCCCCCCHHHH	61.11	23954790
147	Phosphorylation	SKEMDRETLIDVART CCCCCHHHHHHHHHH	29.88	25195567
175	Phosphorylation	LTEAVVDSILAIRKK HHHHHHHHHHHHHCC	14.11	-
199	Ubiquitination	EIMEMKHKSETDTSL EHHHHHCCCCCCCHH	44.46	-
199	Malonylation	EIMEMKHKSETDTSL EHHHHHCCCCCCCHH	44.46	26320211
199	Acetylation	EIMEMKHKSETDTSL EHHHHHCCCCCCCHH	44.46	23806337
200	Phosphorylation	IMEMKHKSETDTSLI HHHHHCCCCCCCHHH	45.51	25619855
202	Phosphorylation	EMKHKSETDTSLIRG HHHCCCCCCCHHHHH	52.23	25619855
204	Phosphorylation	KHKSETDTSLIRGLV HCCCCCCCHHHHHHH	32.62	25619855
205	Phosphorylation	HKSETDTSLIRGLVL CCCCCCCHHHHHHHH	25.30	21082442
241	Ubiquitination	NVSLEYEKTEVNSGF EEEEEEEEEEECCCC	49.43	-
246	Phosphorylation	YEKTEVNSGFFYKSA EEEEEECCCCCCCCH	42.00	22006019
250	Phosphorylation	EVNSGFFYKSAEERE EECCCCCCCCHHHHH	11.19	29514104
251	Ubiquitination	VNSGFFYKSAEEREK ECCCCCCCCHHHHHH	37.72	22790023
251	Acetylation	VNSGFFYKSAEEREK ECCCCCCCCHHHHHH	37.72	22826441
287	Acetylation	KVCGDSDKGFVVINQ HHHCCCCCCEEEEEC	59.19	23806337
295	Ubiquitination	GFVVINQKGIDPFSL CEEEEECCCCCCCCH	54.03	-
295	Succinylation	GFVVINQKGIDPFSL CEEEEECCCCCCCCH	54.03	23954790
307	Acetylation	FSLDALAKEGIVALR CCHHHHHHHCHHHHH	58.27	22826441
307	Ubiquitination	FSLDALAKEGIVALR CCHHHHHHHCHHHHH	58.27	22790023
365	Ubiquitination	EKFTFIEKCNNPRSV CEEEEEECCCCCCEE	37.13	-
365	Acetylation	EKFTFIEKCNNPRSV CEEEEEECCCCCCEE	37.13	23806337
365	Malonylation	EKFTFIEKCNNPRSV CEEEEEECCCCCCEE	37.13	26320211
366	Glutathionylation	KFTFIEKCNNPRSVT EEEEEECCCCCCEEE	3.74	24333276
377	Acetylation	RSVTLLVKGPNKHTL CEEEEEEECCCCCCH	69.49	129777
377	Malonylation	RSVTLLVKGPNKHTL CEEEEEEECCCCCCH	69.49	26320211
377	Ubiquitination	RSVTLLVKGPNKHTL CEEEEEEECCCCCCH	69.49	-
381	Malonylation	LLVKGPNKHTLTQIK EEEECCCCCCHHHHH	40.89	26320211
381	Acetylation	LLVKGPNKHTLTQIK EEEECCCCCCHHHHH	40.89	23806337
388	Acetylation	KHTLTQIKDAIRDGL CCCHHHHHHHHHHHH	31.15	23954790
388	Succinylation	KHTLTQIKDAIRDGL CCCHHHHHHHHHHHH	31.15	23954790
406	S-nitrosocysteine	KNAIDDGCVVPGAGA HHHCCCCCCCCCCCH	3.43	-
406	S-nitrosylation	KNAIDDGCVVPGAGA HHHCCCCCCCCCCCH	3.43	21278135
406	Glutathionylation	KNAIDDGCVVPGAGA HHHCCCCCCCCCCCH	3.43	24333276
426	Ubiquitination	AEALIKYKPSVKGRA HHHHHHCCCCCCCCH	26.30	-
527	Phosphorylation	EIMRAGMSSLKG--- HHHHHHHHHCCC---	31.44	21183079
530	Ubiquitination	RAGMSSLKG------ HHHHHHCCC------	65.60	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPZ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPZ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPZ_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPB_MOUSE	Cct2	physical	9250675
TCPE_MOUSE	Cct5	physical	9250675

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.