TCPE_MOUSE - dbPTM
TCPE_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCPE_MOUSE
UniProt AC P80316
Protein Name T-complex protein 1 subunit epsilon
Gene Name Cct5
Organism Mus musculus (Mouse).
Sequence Length 541
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Description Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)..
Protein Sequence MASVGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTITNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLDKISDKVLVDINNPEPLIQTAKTTLGSKVINSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVVDAKIAILTCPFEPPKPKTKHKLDVMSVEDYKALQKYEKEKFEEMIKQIKETGANLAICQWGFDDEANHLLLQNGLPAVRWVGGPEIELIAIATGGRIVPRFSELTSEKLGFAGVVQEISFGTTKDKMLVIEKCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKESNPALGIDCLHKGSNDMQYQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASVGTLAF
------CCCCCCEEE		16.96-
3Phosphorylation-----MASVGTLAFD
-----CCCCCCEEEC		21.5626824392
6Phosphorylation--MASVGTLAFDEYG
--CCCCCCEEECCCC		16.8626643407
20UbiquitinationGRPFLIIKDQDRKSR
CCEEEEEECCCHHHH		42.2022790023
26PhosphorylationIKDQDRKSRLMGLEA
EECCCHHHHHCCHHH		31.3825521595
35AcetylationLMGLEALKSHIMAAK
HCCHHHHHHHHHHHH		47.2222826441
51PhosphorylationVANTMRTSLGPNGLD
HHHHHHHCCCCCCHH		22.4422871156
59UbiquitinationLGPNGLDKMMVDKDG
CCCCCHHCEEECCCC		33.6622790023
64UbiquitinationLDKMMVDKDGDVTIT
HHCEEECCCCCEEEE		52.8022790023
132UbiquitinationDRGIHPIRIADGYEQ
HCCCCCEEECCCHHH		23.6127667366
150UbiquitinationIAIQHLDKISDKVLV
HHHHHHHHCCCCEEE		50.9322790023
150AcetylationIAIQHLDKISDKVLV
HHHHHHHHCCCCEEE		50.9323236377
154UbiquitinationHLDKISDKVLVDINN
HHHHCCCCEEECCCC		30.5822790023
154AcetylationHLDKISDKVLVDINN
HHHHCCCCEEECCCC		30.5823236377
168PhosphorylationNPEPLIQTAKTTLGS
CCHHHHHHHHHHHHH		24.1126643407
170UbiquitinationEPLIQTAKTTLGSKV
HHHHHHHHHHHHHHH		45.4927667366
170MalonylationEPLIQTAKTTLGSKV
HHHHHHHHHHHHHHH		45.4926320211
171PhosphorylationPLIQTAKTTLGSKVI
HHHHHHHHHHHHHHH		25.4526643407
172PhosphorylationLIQTAKTTLGSKVIN
HHHHHHHHHHHHHHH		28.5426643407
175PhosphorylationTAKTTLGSKVINSCH
HHHHHHHHHHHHHHH		27.1926643407
181GlutathionylationGSKVINSCHRQMAEI
HHHHHHHHHHHHHHH		2.3724333276
181S-nitrosylationGSKVINSCHRQMAEI
HHHHHHHHHHHHHHH		2.3720925432
181S-nitrosocysteineGSKVINSCHRQMAEI
HHHHHHHHHHHHHHH		2.37-
210UbiquitinationDVDFELIKVEGKVGG
CCCEEEEEEECEECC		47.0222790023
223MalonylationGGRLEDTKLIKGVIV
CCCCCCCEEEEEEEE		61.6126320211
223AcetylationGGRLEDTKLIKGVIV
CCCCCCCEEEEEEEE		61.6123201123
232AcetylationIKGVIVDKDFSHPQM
EEEEEECCCCCCCCC		50.1823806337
235PhosphorylationVIVDKDFSHPQMPKK
EEECCCCCCCCCCCC		44.3728285833
253S-nitrosylationAKIAILTCPFEPPKP
CEEEEEECCCCCCCC		3.0520925432
253S-palmitoylationAKIAILTCPFEPPKP
CEEEEEECCCCCCCC		3.0528526873
253S-nitrosocysteineAKIAILTCPFEPPKP
CEEEEEECCCCCCCC		3.05-
253GlutathionylationAKIAILTCPFEPPKP
CEEEEEECCCCCCCC		3.0524333276
259AcetylationTCPFEPPKPKTKHKL
ECCCCCCCCCCCCCC		70.6222826441
265UbiquitinationPKPKTKHKLDVMSVE
CCCCCCCCCCCCCHH		48.1922790023
265AcetylationPKPKTKHKLDVMSVE
CCCCCCCCCCCCCHH		48.1923806337
270PhosphorylationKHKLDVMSVEDYKAL
CCCCCCCCHHHHHHH		23.3929514104
275UbiquitinationVMSVEDYKALQKYEK
CCCHHHHHHHHHHHH		55.7522790023
282AcetylationKALQKYEKEKFEEMI
HHHHHHHHHHHHHHH		64.216568951
302S-palmitoylationTGANLAICQWGFDDE
HCCCEEEEECCCCHH		2.0128680068
302GlutathionylationTGANLAICQWGFDDE
HCCCEEEEECCCCHH		2.0124333276
346PhosphorylationGRIVPRFSELTSEKL
CCEECCHHHHCCCHH		32.7322817900
368UbiquitinationEISFGTTKDKMLVIE
EEECCCCCCCEEEEE		56.01-
370UbiquitinationSFGTTKDKMLVIEKC
ECCCCCCCEEEEEEC		35.37-
370AcetylationSFGTTKDKMLVIEKC
ECCCCCCCEEEEEEC		35.3723201123
376MalonylationDKMLVIEKCKNSRAV
CCEEEEEECCCCCEE		39.1126320211
377GlutathionylationKMLVIEKCKNSRAVT
CEEEEEECCCCCEEE		3.0624333276
392UbiquitinationIFIRGGNKMIIEEAK
EEEECCCEEHHHHHH		34.4522790023
399SuccinylationKMIIEEAKRSLHDAL
EEHHHHHHHHHHHHH		45.8823954790
407S-nitrosylationRSLHDALCVIRNLIR
HHHHHHHHHHHHHHC		2.2824926564
407S-nitrosocysteineRSLHDALCVIRNLIR
HHHHHHHHHHHHHHC		2.28-
476UbiquitinationNPIQTMTEVRARQVK
CCCCCHHHHHHHHHH		21.1327667366
483UbiquitinationEVRARQVKESNPALG
HHHHHHHHHHCCCCC		47.27-
485PhosphorylationRARQVKESNPALGID
HHHHHHHHCCCCCEE		42.2525521595
493S-nitrosocysteineNPALGIDCLHKGSND
CCCCCEECCCCCCCH		3.97-
493S-palmitoylationNPALGIDCLHKGSND
CCCCCEECCCCCCCH		3.9728526873
493S-nitrosylationNPALGIDCLHKGSND
CCCCCEECCCCCCCH		3.9720925432
493GlutathionylationNPALGIDCLHKGSND
CCCCCEECCCCCCCH		3.9724333276
514UbiquitinationIETLIGKKQQISLAT
HHHHHCHHHHHHHHH		42.0727667366
521PhosphorylationKQQISLATQMVRMIL
HHHHHHHHHHHHHHH		23.61-
529AcetylationQMVRMILKIDDIRKP
HHHHHHHCHHHCCCC		32.9122826441
529UbiquitinationQMVRMILKIDDIRKP
HHHHHHHCHHHCCCC		32.91-
535UbiquitinationLKIDDIRKPGESEE-
HCHHHCCCCCCCCC-		58.68-
539PhosphorylationDIRKPGESEE-----
HCCCCCCCCC-----		53.6029514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCPE_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCPE_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCPE_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPA_MOUSETcp1physical
9250675
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCPE_MOUSE

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Related Literatures of Post-Translational Modification

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