PSB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB3_MOUSE
• UniProt AC: Q9R1P1
• Protein Name: Proteasome subunit beta type-3
• Gene Name: Psmb3
• Organism: Mus musculus (Mouse).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSIMSYNGG ------CCCCCCCCC	27.31	16857966
15	Ubiquitination	GGAVMAMKGKNCVAI CCEEEEECCCCEEEE	58.14	-
17	Ubiquitination	AVMAMKGKNCVAIAA EEEEECCCCEEEEEE	41.47	-
17	Malonylation	AVMAMKGKNCVAIAA EEEEECCCCEEEEEE	41.47	26320211
19	S-nitrosocysteine	MAMKGKNCVAIAADR EEECCCCEEEEEECC	2.20	-
19	Glutathionylation	MAMKGKNCVAIAADR EEECCCCEEEEEECC	2.20	24333276
19	S-nitrosylation	MAMKGKNCVAIAADR EEECCCCEEEEEECC	2.20	21278135
77	Acetylation	RLNLYELKEGRQIKP HHHHEEHHCCCCCCH	46.30	23806337
77	Ubiquitination	RLNLYELKEGRQIKP HHHHEEHHCCCCCCH	46.30	-
77	Malonylation	RLNLYELKEGRQIKP HHHHEEHHCCCCCCH	46.30	26320211
98	Ubiquitination	VANLLYEKRFGPYYT HHHHHHHHHHCCCCC	39.20	-
103	Phosphorylation	YEKRFGPYYTEPVIA HHHHHCCCCCCCEEC	24.33	20415495
104	Phosphorylation	EKRFGPYYTEPVIAG HHHHCCCCCCCEECC	14.04	20415495
105	Phosphorylation	KRFGPYYTEPVIAGL HHHCCCCCCCEECCC	28.15	20415495
181	Phosphorylation	AVDRDAVSGMGVIVH CCCHHHHCCCEEEEE	25.45	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSB3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.