K2C72_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C72_MOUSE
• UniProt AC: Q6IME9
• Protein Name: Keratin, type II cytoskeletal 72
• Gene Name: Krt72
• Organism: Mus musculus (Mouse).
• Sequence Length: 520
• Protein Description: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)..
• Protein Sequence: MSRQLTLYPGAERLGFSGCSAVISGRLSGSHASVRAGVKGAAFGSRSLFCVGGGRRLALSSAGRSGGFTLGHGGASGGRPGGFVGTVFGSAGLGPTCPSVCPPGGIPQVVVNKSLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNSKRSLEPVHESYISNLQKQLEILSGDRVRLDSELRNMREVVEDCKKRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSLTDDIKFFKVLFEGEIAQMQSHISDTSVILSMDNNRQLDLDSILAEVRAQYEEIAVKSKAETENMYQCKIQELQATAGQHGDDLKHTKSEITEINRLIQRIHSEIGNMKKQCSNLETAIADAEQRGDCALKDARAKLDQLEGALQQAKEELARMLREHQELMNVKLALDMEIATYRKLLESEESRMAGEYPNSVSISVISSTNAGPGGAGFSVGFGASSSYNYRPLALEVKTKGSCGSELKDPPAKTSGSSGTTKKTSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	ISGRLSGSHASVRAG EECCCCCCCCCHHHC	16.71	21454597
147	Phosphorylation	ALNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	29472430
151	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C72_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C72_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C72_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C72_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.