EXOC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOC1_MOUSE
• UniProt AC: Q8R3S6
• Protein Name: Exocyst complex component 1
• Gene Name: Exoc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 894
• Subcellular Localization: Midbody, Midbody ring . Colocalizes with CNTRL/centriolin at the midbody ring.
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
• Protein Sequence: MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKVYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSVAGGDEEAVDEYQELNAREEQDIEIMMEGCECAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNTLMQLLDEALTEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLVSSRGIEACTNAADALLQCMNVALRPGHDMLLAVKQQQQRFSDLREHFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKMKMTGTSKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGSRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQNMSASMTEAEDLDGGSLLRQHSSGTLLPVSSEKDMIRQMMIKIFRCIEPELNNLIALGDKVDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFINVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	VYKWVASSTAEKNAF HHHHHHCCHHHHCHH	23.15	27566939
430	Acetylation	KDFFEVAKMKMTGTS HHHHHHHHCCCCCCC	44.20	2388573
445	Phosphorylation	KESKKFATLPRKESA HHHHCCCCCCCCHHH	40.19	21454597
451	Phosphorylation	ATLPRKESAVKQETE CCCCCCHHHHHHHHH	41.20	25266776
459	Phosphorylation	AVKQETESLHGSSGK HHHHHHHHHCCCCCE	32.84	30352176
463	Phosphorylation	ETESLHGSSGKLTGS HHHHHCCCCCEECCC	25.77	27841257
464	Phosphorylation	TESLHGSSGKLTGST HHHHCCCCCEECCCC	44.53	27841257
468	Phosphorylation	HGSSGKLTGSTSSLN CCCCCEECCCCHHHC	32.35	25168779
470	Phosphorylation	SSGKLTGSTSSLNKL CCCEECCCCHHHCCE	21.63	25521595
471	Phosphorylation	SGKLTGSTSSLNKLS CCEECCCCHHHCCEE	24.55	22942356
472	Phosphorylation	GKLTGSTSSLNKLSV CEECCCCHHHCCEEC	34.23	25521595
473	Phosphorylation	KLTGSTSSLNKLSVQ EECCCCHHHCCEECC	35.73	25521595
478	Phosphorylation	TSSLNKLSVQSSGSR CHHHCCEECCCCCCC	21.51	21454597
481	Phosphorylation	LNKLSVQSSGSRRSQ HCCEECCCCCCCCCC	34.21	29899451
482	Phosphorylation	NKLSVQSSGSRRSQS CCEECCCCCCCCCCC	24.56	29472430
484	Phosphorylation	LSVQSSGSRRSQSSS EECCCCCCCCCCCCC	26.86	22324799
487	Phosphorylation	QSSGSRRSQSSSLLD CCCCCCCCCCCCCHH	33.05	25619855
489	Phosphorylation	SGSRRSQSSSLLDMG CCCCCCCCCCCHHHC	24.12	27742792
490	Phosphorylation	GSRRSQSSSLLDMGN CCCCCCCCCCHHHCC	19.85	25619855
491	Phosphorylation	SRRSQSSSLLDMGNM CCCCCCCCCHHHCCC	37.89	27742792
499	Phosphorylation	LLDMGNMSASDLDVA CHHHCCCCHHHCCHH	28.72	27742792
501	Phosphorylation	DMGNMSASDLDVADR HHCCCCHHHCCHHCH	31.25	27087446
509	Phosphorylation	DLDVADRTKFDKIFE HCCHHCHHHHHHHHH	36.29	26643407
559	Phosphorylation	AEDLDGGSLLRQHSS HHHCCCCCCEEECCC	29.75	26643407
565	Phosphorylation	GSLLRQHSSGTLLPV CCCEEECCCCCEEEC	23.33	27818261
566	Phosphorylation	SLLRQHSSGTLLPVS CCEEECCCCCEEECC	33.40	21082442
568	Phosphorylation	LRQHSSGTLLPVSSE EEECCCCCEEECCCH	27.37	30372032
573	Phosphorylation	SGTLLPVSSEKDMIR CCCEEECCCHHHHHH	30.73	26643407
574	Phosphorylation	GTLLPVSSEKDMIRQ CCEEECCCHHHHHHH	49.23	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.