DNJA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJA1_MOUSE
• UniProt AC: P63037
• Protein Name: DnaJ homolog subfamily A member 1
• Gene Name: Dnaja1
• Organism: Mus musculus (Mouse).
• Sequence Length: 397
• Subcellular Localization: Membrane; Lipid-anchor. Cytoplasm. Microsome. Mitochondrion. Nucleus. Cytoplasm, perinuclear region. Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity)..
• Protein Description: Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis..
• Protein Sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MVKETTYYDV -----CCCEEEEEEH	48.31	22790023
7	Phosphorylation	-MVKETTYYDVLGVK -CCCEEEEEEHHCCC	12.70	29514104
14	Ubiquitination	YYDVLGVKPNATQEE EEEHHCCCCCCCHHH	30.65	22790023
23	Acetylation	NATQEELKKAYRKLA CCCHHHHHHHHHHHH	38.34	23864654
23	Ubiquitination	NATQEELKKAYRKLA CCCHHHHHHHHHHHH	38.34	22790023
32	Ubiquitination	AYRKLALKYHPDKNP HHHHHHHHHCCCCCC	35.59	-
32	Malonylation	AYRKLALKYHPDKNP HHHHHHHHHCCCCCC	35.59	26320211
37	Acetylation	ALKYHPDKNPNEGEK HHHHCCCCCCCCCHH	77.93	23806337
37	Ubiquitination	ALKYHPDKNPNEGEK HHHHCCCCCCCCCHH	77.93	22790023
44	Ubiquitination	KNPNEGEKFKQISQA CCCCCCHHHHHHHHH	69.58	22790023
46	Ubiquitination	PNEGEKFKQISQAYE CCCCHHHHHHHHHHH	58.76	22790023
52	Phosphorylation	FKQISQAYEVLADSK HHHHHHHHHHHHHHH	10.03	29514104
59	Ubiquitination	YEVLADSKKRELYDK HHHHHHHHCHHHHHC	57.29	22790023
66	Ubiquitination	KKRELYDKGGEQAIK HCHHHHHCHHHHHHH	56.08	-
66	Acetylation	KKRELYDKGGEQAIK HCHHHHHCHHHHHHH	56.08	-
66	Malonylation	KKRELYDKGGEQAIK HCHHHHHCHHHHHHH	56.08	26320211
83	Phosphorylation	GAGGGFGSPMDIFDM CCCCCCCCHHHHHHH	18.13	26643407
105	Ubiquitination	MQRERRGKNVVHQLS HHHHHCCCCCEEEEE	44.77	-
112	Phosphorylation	KNVVHQLSVTLEDLY CCCEEEEECCHHHHH	13.39	26745281
114	Phosphorylation	VVHQLSVTLEDLYNG CEEEEECCHHHHHCC	22.51	23984901
119	Phosphorylation	SVTLEDLYNGATRKL ECCHHHHHCCHHHHH	24.71	-
136	Ubiquitination	QKNVICDKCEGRGGK HCCEEEECCCCCCCC	29.76	-
136	Acetylation	QKNVICDKCEGRGGK HCCEEEECCCCCCCC	29.76	23201123
136	Malonylation	QKNVICDKCEGRGGK HCCEEEECCCCCCCC	29.76	26320211
143	Ubiquitination	KCEGRGGKKGAVECC CCCCCCCCCCCEEEC	51.35	-
144	Ubiquitination	CEGRGGKKGAVECCP CCCCCCCCCCEEECC	56.21	-
175	Phosphorylation	GMVQQIQSVCMECQG HHHHHHHHHHHHCCC	20.93	29899451
252	Phosphorylation	QKDHAVFTRRGEDLF CCCCEEEEECCCCEE	16.92	21082442
296	Ubiquitination	SHPGQIVKHGDIKCV CCCCCEEECCCEEEE	43.42	22790023
302	S-nitrosylation	VKHGDIKCVLNEGMP EECCCEEEEEECCCC	4.26	20925432
302	S-nitrosocysteine	VKHGDIKCVLNEGMP EECCCEEEEEECCCC	4.26	-
335	Phosphorylation	FPENGFLSPDKLSLL CCCCCCCCHHHHHHH	28.88	25521595
338	Ubiquitination	NGFLSPDKLSLLEKL CCCCCHHHHHHHHHH	43.27	22790023
340	Phosphorylation	FLSPDKLSLLEKLLP CCCHHHHHHHHHHCC	36.33	26824392
344	Ubiquitination	DKLSLLEKLLPERKE HHHHHHHHHCCCCCC	56.12	22790023
381	Phosphorylation	RHYNGEAYEDDEHHP HHCCCCCCCCCCCCC	18.65	25159016
394	Methylation	HPRGGVQCQTS---- CCCCCCCCCCC----	4.41	-
394	Farnesylation	HPRGGVQCQTS---- CCCCCCCCCCC----	4.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DNJA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.