KNTC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KNTC1_MOUSE
• UniProt AC: Q8C3Y4
• Protein Name: Kinetochore-associated protein 1
• Gene Name: Kntc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 2207
• Subcellular Localization: Cytoplasm . Nucleus . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle .
• Protein Description: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity)..
• Protein Sequence: MWNNIELLTSDDTGSGCLSVGSRKENVTALYQADLLGKISSEKTSLSPKIQAFSLSHGFIIVADQSVILLDSICRSLQLFLIFDTDVDVVGLCQEGKFLFVGERSGNFHLIYVTSKQTLFTKAFVEKALDESQRTYRNLIIEKDGSNEGTYYMLLLTNNGFFYITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTENYHSCLSLVASQSGTFASKTSVIIGGTGSCAFSKWEPDSTKKEMSLKNFVGTDIIKGAKSFQLIDNLLFVLDTDNVLSLWDAYTLTPVWNWPSLPVEQFVLTTEADSPSSVTWQGITNLKLVTLTATAKEKMRSLIIYSLPSMETLYSLEVSSVSSLVQTGISTDTIYLLEGIHKNDPNLCEDSVSDLVLRYLTEVLPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDMLEKLALISSDKSEQSKWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRALPASSDAFMEVLKAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLRDVFLQLSEGNFACAQYLWLRHRADFESKFDVKMLENLLNSISTQFPLENLCSWFKNEVIPFVRRIVPEGQNILAKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDRFGFASSWHWISLDYQNTEEVRQLRTLVSKLRELIILHRKYNCKLALSDFEKENATTVVFRMFDRVSAPELIPSVLEKSVRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFDAVLKIMYKAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNLLNKEIMRVIRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRIIDLIDREQGGDCLLLLKSLPAAEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSVDILKILCDIRKDNLQKKDESEEFLKRFQMVASLQENFEVFLPFEDYSNTALVAGLREQYIKAQEAAQAEHKHRGPPGPTPARGTHLSIKSKLHRQALALQVSEQELEAELTLRALKDGKVVAALSKCRDLLKHYCNADTGRLLFVVCQKLCQMLADDVPMVAPGGLSLPSEIHDLACHAVTICSPDYLLDVLELSKYTLTAVELCRQCQMDDCGMLMKAALGTHKDPYEEWSFSDFFSEDGIVLESQVVLPVIYELISSVMPPAESKRHPLDSISLPYCSTSEGENRILPLVSSISALLRSLQECSQWELALRFVVGSFGTCLQHSMSNVMSISLSKQLLGKNTLANSRHIIMELKEKSITFIRENATTLLHKVFNCRVVDLDLALAYCTLLPQKDVFDNLWKFIDKAWQNYDKILALSLVGSQLANLYQDIETGLWFHELSIDAKWGIRLGKLGISFQPAFRQNFLTKKDLIKALVNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTSSQSQGDAAPESTKHQHSKLLAKATELVPLLKNTKDLVISLSEILYKLDPYDYEMIDVVLKVLEQANEKITSVNINQALNLLRHLKSYRRISPPVDHEYQYALEHMITLPPAAHTRLPFHLILFGTAQNFWKILSSELSEESLPTLLLIAKLMKFSLDTLYVSTAKHLFEKNLKPKLLKSAQARSSTLMSKEVDKLMQTLESYLLSIVNPEWAVAIAISLTQEVPEGPFKMSSLKFCLYLAERWLQNIPPQDETCEKAKALQKKLCLQVRLSGTEAVLIAHKLNDQEYLRVIGKPAHLIVSLYEHPSISERLCTTSGKDYPDIHTAAKEIAEVNEVNLEKIWDMLLEKWLCPSTVPSEKASEFFELEEDEVLHRVVYLLQARPVDYCSRMLFVFATSATSTLGMRQLTFAHKARALQCLLYLADKETIESLFKKPIKEMKSYLKCITFLASFETLNIPITYELFCNSPKEGMIKGLWKNHSHEPMAVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSIHSLWQVPYFSKAWQRVIQIPLLSASCPLRPSQLADCCDSLVAILECPVSDDLDMMGVAKQYVQLDLPAFALTCLTLMPHSEKRHQQIKNFLNSCDARIILQQIEEHMNTGQLAGFSHQIGSLVLNHVVNKKEFGILAKTKYFQLLKCHVINTGNVTELVNYLANDFSVDEASALINEYSKHCGKPVPADAAPCEILQTFLGGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	WNNIELLTSDDTGSG CCCEEEEECCCCCCC	42.61	26643407
10	Phosphorylation	NNIELLTSDDTGSGC CCEEEEECCCCCCCC	33.20	26643407
13	Phosphorylation	ELLTSDDTGSGCLSV EEEECCCCCCCCCCC	37.93	26643407
15	Phosphorylation	LTSDDTGSGCLSVGS EECCCCCCCCCCCCC	28.55	26643407
19	Phosphorylation	DTGSGCLSVGSRKEN CCCCCCCCCCCCCCC	28.63	26643407
22	Phosphorylation	SGCLSVGSRKENVTA CCCCCCCCCCCCEEH	37.71	26643407
44	Phosphorylation	GKISSEKTSLSPKIQ HHCCCCCCCCCHHHH	30.74	28285833
45	Phosphorylation	KISSEKTSLSPKIQA HCCCCCCCCCHHHHE	37.61	28285833
47	Phosphorylation	SSEKTSLSPKIQAFS CCCCCCCCHHHHEEE	24.74	28285833
632	Phosphorylation	AKWLEQASRNLELTD HHHHHHHHHHCCCCC	22.77	20139300
788	Dimethylation	AKAMAVIRCLSDTDL HHHHHHHHHCCCHHH	14.55	-
788	Methylation	AKAMAVIRCLSDTDL HHHHHHHHHCCCHHH	14.55	18965539
895	Phosphorylation	RLSDDEIYSLRIIDL CCCCCCEEEEEEEEC	10.29	26239621
896	Phosphorylation	LSDDEIYSLRIIDLI CCCCCEEEEEEEECC	19.48	26239621
1316	Acetylation	RHIIMELKEKSITFI HHHHHHHHHHCEEEE	50.19	23236377
1328	Phosphorylation	TFIRENATTLLHKVF EEECCCHHHHHHHHH	29.56	28059163
1329	Phosphorylation	FIRENATTLLHKVFN EECCCHHHHHHHHHC	25.55	28059163
1355	Acetylation	YCTLLPQKDVFDNLW HHHHCCCHHHHHHHH	54.65	19855979
1363	Acetylation	DVFDNLWKFIDKAWQ HHHHHHHHHHHHHHH	35.29	7618013
1485	Phosphorylation	QGDAAPESTKHQHSK CCCCCCCCHHHHHHH	41.52	22982522
1486	Phosphorylation	GDAAPESTKHQHSKL CCCCCCCHHHHHHHH	30.77	22982522
1542	Ubiquitination	VLEQANEKITSVNIN HHHHHHHHCCCCCHH	51.60	-
1632	Phosphorylation	LMKFSLDTLYVSTAK HHCCCCCHHHHHHHH	25.86	29550500
1634	Phosphorylation	KFSLDTLYVSTAKHL CCCCCHHHHHHHHHH	8.41	29550500
1636	Phosphorylation	SLDTLYVSTAKHLFE CCCHHHHHHHHHHHH	14.75	29550500
1637	Phosphorylation	LDTLYVSTAKHLFEK CCHHHHHHHHHHHHC	29.67	29550500
1639	Acetylation	TLYVSTAKHLFEKNL HHHHHHHHHHHHCCC	40.71	7614383
1644	Acetylation	TAKHLFEKNLKPKLL HHHHHHHCCCCHHHH	61.31	19856737
1706	Phosphorylation	EGPFKMSSLKFCLYL CCCCCHHHHHHHHHH	31.89	24759943
1745	Phosphorylation	LCLQVRLSGTEAVLI HCCEEECCCCCEEEE	32.86	29899451
2145	Phosphorylation	GILAKTKYFQLLKCH CCEEECHHHEEEEEE	11.20	21454597

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KNTC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KNTC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KNTC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KNTC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.