HEXA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEXA_MOUSE
• UniProt AC: P29416
• Protein Name: Beta-hexosaminidase subunit alpha
• Gene Name: Hexa
• Organism: Mus musculus (Mouse).
• Sequence Length: 528
• Subcellular Localization: Lysosome.
• Protein Description: Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues..
• Protein Sequence: MAGCRLWVSLLLAAALACLATALWPWPQYIQTYHRRYTLYPNNFQFRYHVSSAAQAGCVVLDEAFRRYRNLLFGSGSWPRPSFSNKQQTLGKNILVVSVVTAECNEFPNLESVENYTLTINDDQCLLASETVWGALRGLETFSQLVWKSAEGTFFINKTKIKDFPRFPHRGVLLDTSRHYLPLSSILDTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGAPGLLTPCYSGSHLSGTFGPVNPSLNSTYDFMSTLFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDFKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVEYMLEMQDITRAGFRALLSAPWYLNRVKYGPDWKDMYKVEPLAFHGTPEQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAVAERLWSSNLTTNIDFAFKRLSHFRCELVRRGIQAQPISVGYCEQEFEQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
115	N-linked_Glycosylation	PNLESVENYTLTIND CCCCCEEEEEEEECC	32.69	-
157	N-linked_Glycosylation	AEGTFFINKTKIKDF CCCEEEEECCCCCCC	40.56	-
197	Acetylation	LDVMAYNKFNVFHWH HHHHHHCCCCEEEEE	26.16	7629137
295	N-linked_Glycosylation	GPVNPSLNSTYDFMS CCCCCCCCCHHHHHH	36.32	-
352	Phosphorylation	TDFKQLESFYIQTLL CCHHHHHHHHHHHHH	31.76	25338131
354	Phosphorylation	FKQLESFYIQTLLDI HHHHHHHHHHHHHHH	11.03	25338131
416	Phosphorylation	AGFRALLSAPWYLNR HHHHHHHCCCHHHCC	32.89	24719451
420	Phosphorylation	ALLSAPWYLNRVKYG HHHCCCHHHCCCCCC	7.95	24719451
487	N-linked_Glycosylation	AERLWSSNLTTNIDF HHHHHHCCCCCCCHH	35.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEXA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEXA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEXA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HEXA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.