PSB6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB6_MOUSE
• UniProt AC: Q60692
• Protein Name: Proteasome subunit beta type-6
• Gene Name: Psmb6
• Organism: Mus musculus (Mouse).
• Sequence Length: 238
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues..
• Protein Sequence: MAAALAVRRAGSAPAFGPEALTPDWENREVSTGTTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATLPPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAALAVRR ------CHHHHHHHH	11.05	-
12	Phosphorylation	LAVRRAGSAPAFGPE HHHHHHCCCCCCCCC	30.05	27180971
22	Phosphorylation	AFGPEALTPDWENRE CCCCCCCCCCCCCCC	26.67	22942356
53	Phosphorylation	VLGADSRTTTGSYIA EECCCCCCCCCCHHH	32.44	25367039
54	Phosphorylation	LGADSRTTTGSYIAN ECCCCCCCCCCHHHH	28.22	25367039
55	Phosphorylation	GADSRTTTGSYIANR CCCCCCCCCCHHHHH	24.42	25367039
57	Phosphorylation	DSRTTTGSYIANRVT CCCCCCCCHHHHHHC	15.98	29472430
58	Phosphorylation	SRTTTGSYIANRVTD CCCCCCCHHHHHHCC	12.85	25367039
66	Acetylation	IANRVTDKLTPIHDH HHHHHCCCCCCCCCC	44.91	22826441
68	Phosphorylation	NRVTDKLTPIHDHIF HHHCCCCCCCCCCEE	26.41	-
157	Phosphorylation	GGMMVRQSFAIGGSG CCEEEEEEEEECCCC	13.19	18579562
185	Glutathionylation	EGMTKDECLQFTANA CCCCHHHHHHHHHHH	5.33	24333276
202	Phosphorylation	LAMERDGSSGGVIRL HHHHCCCCCCCEEEE	30.05	25521595
215	Phosphorylation	RLAAIQESGVERQVL EEEEEHHHCCEEEEE	31.59	28464351

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSB6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.