TMM43_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM43_MOUSE
• UniProt AC: Q9DBS1
• Protein Name: Transmembrane protein 43
• Gene Name: Tmem43
• Organism: Mus musculus (Mouse).
• Sequence Length: 400
• Subcellular Localization: Endoplasmic reticulum. Nucleus inner membrane; Multi-pass membrane protein. Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrop
• Protein Description: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane..
• Protein Sequence: MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAANYSSTS ------CCCCCCCCC	12.38	-
5	Phosphorylation	---MAANYSSTSSRK ---CCCCCCCCCCCC	10.16	29514104
7	Phosphorylation	-MAANYSSTSSRKEH -CCCCCCCCCCCCCC	23.19	23375375
8	Phosphorylation	MAANYSSTSSRKEHV CCCCCCCCCCCCCCE	25.44	23375375
9	Phosphorylation	AANYSSTSSRKEHVK CCCCCCCCCCCCCEE	30.05	23375375
10	Phosphorylation	ANYSSTSSRKEHVKV CCCCCCCCCCCCEEE	47.67	25266776
210	Acetylation	FKALSLAKLEDPHVD CHHHHCCCCCCCCCC	58.67	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM43_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM43_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM43_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TMM43_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.