IPO7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPO7_MOUSE
• UniProt AC: Q9EPL8
• Protein Name: Importin-7
• Gene Name: Ipo7
• Organism: Mus musculus (Mouse).
• Sequence Length: 1038
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones..
• Protein Sequence: MDPNTIIEALRGTMDPALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNMITQYWPDREATPGDIAPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTAIVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQSDQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWVEILKTVVNRDVPNETLQVEEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVLQQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQMEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSELRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLCALIDMEQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDEDAEDDDETEELGSDEDDIDEDGQEYLEILAKQAGEDGDDEDWEEDDAEETALEGYSTIIDDEDNPVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKHGGYKFSAPVVPSSFNFGGPAPGMN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPNTIIE -------CCHHHHHH	63.56	-
5	Phosphorylation	---MDPNTIIEALRG ---CCHHHHHHHHHC	28.81	27180971
37	Phosphorylation	HKSLNFVSTLLQITM HHHHCHHHHHHHHHH	14.81	28059163
45	Phosphorylation	TLLQITMSEQLDLPV HHHHHHHHHCCCCCH	17.34	28059163
283	Ubiquitination	GSPGNVSKEYNEFAE CCCCCCCHHHHHHHH	60.99	-
410	Acetylation	KRKEVLQKTMGFCYQ HHHHHHHHHHCHHHH	36.00	23201123
477	S-nitrosocysteine	GYMRARACWVLHYFC HHHHHHHHHHHHHHH	1.84	-
477	S-nitrosylation	GYMRARACWVLHYFC HHHHHHHHHHHHHHH	1.84	20925432
668	Phosphorylation	SLTCQQVSPQMWQLL HCHHCCCCHHHHHHH	12.70	-
757	S-nitrosocysteine	KGRGIDQCIPLFVEA CCCCHHHHHHHHHHH	2.84	-
757	S-nitrosylation	KGRGIDQCIPLFVEA CCCCHHHHHHHHHHH	2.84	21278135
757	Glutathionylation	KGRGIDQCIPLFVEA CCCCHHHHHHHHHHH	2.84	24333276
876	Phosphorylation	FNGLKRAYACHAEHE HHHHHHHHHHHCCCC	17.50	25159016
886	Phosphorylation	HAEHENDSDDDEDAE HCCCCCCCCCCCCCC	55.30	25159016
898	Phosphorylation	DAEDDDETEELGSDE CCCCCHHHHHHCCCC	41.58	23737553
903	Phosphorylation	DETEELGSDEDDIDE HHHHHHCCCCHHCCC	50.91	25159016
915	Phosphorylation	IDEDGQEYLEILAKQ CCCCHHHHHHHHHHH	11.18	23737553
990	Ubiquitination	GLNEEQRKQLQDIAT CCCHHHHHHHHHHHH	55.87	22790023
1017	Phosphorylation	MIEKHGGYKFSAPVV HHHHHCCCCCCCCCC	17.29	25266776
1018	Ubiquitination	IEKHGGYKFSAPVVP HHHHCCCCCCCCCCC	35.80	-
1020	Phosphorylation	KHGGYKFSAPVVPSS HHCCCCCCCCCCCCC	27.75	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPO7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPO7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPO7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IPO7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.