EXOC4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOC4_MOUSE
• UniProt AC: O35382
• Protein Name: Exocyst complex component 4
• Gene Name: Exoc4
• Organism: Mus musculus (Mouse).
• Sequence Length: 975
• Subcellular Localization: Midbody, Midbody ring . Cell projection . Colocalizes with CNTRL/centriolin at the midbody ring (By similarity). Localizes at the leading edge of migrating cells (By similarity).
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
• Protein Sequence: MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIEELHRHLYIKSTSRVVQRNKEKGKMSSHGKDPSPGPLIDVSNIPTPRKFLDASQYSAAGGSSVREMNLQDVKEDLECDPEENSTLFMGILIQGLARLKKIPETVKAIKERLEQELKQIVKRSTTQVADSAYQRGESLTVDNQPRLLLELLELLFDKFNAVATAHSVVLGYLQDSVGTQLTQQEEIKLYDMADVWVKIQDVLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSHAISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFIQEIEHALGLGPAKQCPLREFLTVYIKSIFLNQVLAEINKEIEGVTKTSDPLKILANADTMKVLGVQRPLLQSTIIVEKTVQDLMNLMHDLSAYSDQFLNMVCVKLQEYKDTCSTAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWTNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLAGRTKSAFSNLSTSQMLSPAQESHVNMDLPPVSEQIMQTLSELAKTFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKLNKDISAMEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGDQTTQNTRLQRLKEIICEQAAIKQATKDKKITTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAEAAGGK ------CCCCCCCCC	17.63	-
9	Acetylation	AAEAAGGKYRSTVSK CCCCCCCCCCCCCCC	36.25	23806337
9	Malonylation	AAEAAGGKYRSTVSK CCCCCCCCCCCCCCC	36.25	26320211
17	Phosphorylation	YRSTVSKSKDPSGLL CCCCCCCCCCCCCCH	34.48	20531401
18	Acetylation	RSTVSKSKDPSGLLI CCCCCCCCCCCCCHH	76.91	23806337
21	Phosphorylation	VSKSKDPSGLLISVI CCCCCCCCCCHHEHH	52.81	23984901
26	Phosphorylation	DPSGLLISVIRTLST CCCCCHHEHHHHCCC	16.09	23984901
30	Phosphorylation	LLISVIRTLSTSDDV CHHEHHHHCCCCCCC	17.59	27742792
32	Phosphorylation	ISVIRTLSTSDDVED HEHHHHCCCCCCCCH	25.83	26824392
33	Phosphorylation	SVIRTLSTSDDVEDR EHHHHCCCCCCCCHH	39.01	29899451
34	Phosphorylation	VIRTLSTSDDVEDRE HHHHCCCCCCCCHHH	28.56	26643407
219	Phosphorylation	NKEKGKMSSHGKDPS HHHCCCCCCCCCCCC	23.75	26643407
220	Phosphorylation	KEKGKMSSHGKDPSP HHCCCCCCCCCCCCC	32.53	26643407
226	Phosphorylation	SSHGKDPSPGPLIDV CCCCCCCCCCCCEEC	53.26	26824392
234	Phosphorylation	PGPLIDVSNIPTPRK CCCCEECCCCCCCHH	25.87	24759943
238	Phosphorylation	IDVSNIPTPRKFLDA EECCCCCCCHHHCCH	31.74	26643407
241	Ubiquitination	SNIPTPRKFLDASQY CCCCCCHHHCCHHHH	52.03	-
255	Phosphorylation	YSAAGGSSVREMNLQ HHCCCCCCHHHCCHH	28.59	29514104
292	Malonylation	QGLARLKKIPETVKA HHHHHHCCCHHHHHH	69.00	26320211
322	Phosphorylation	STTQVADSAYQRGES HHHHHHHHHHHCCCC	21.09	25367039
324	Phosphorylation	TQVADSAYQRGESLT HHHHHHHHHCCCCCC	11.60	25367039
466	Phosphorylation	REQRRELYSRSGELQ HHHHHHHHHHCCCCC	9.40	30635358
467	Phosphorylation	EQRRELYSRSGELQG HHHHHHHHHCCCCCC	32.37	30635358
469	Phosphorylation	RRELYSRSGELQGGP HHHHHHHCCCCCCCC	30.58	25521595
567	Phosphorylation	KILANADTMKVLGVQ HHHHCCCHHHHHCCC	19.24	29514104
637	Phosphorylation	SEEKLVISASWAKDD CCCEEEEEEEECCCH	14.58	28576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOC4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOC4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOC4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOC4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.