| UniProt ID | LYOX_MOUSE | |
|---|---|---|
| UniProt AC | P28301 | |
| Protein Name | Protein-lysine 6-oxidase | |
| Gene Name | Lox | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 411 | |
| Subcellular Localization | Secreted . Secreted, extracellular space. | |
| Protein Description | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. [PubMed: 27432961] | |
| Protein Sequence | MRFAWAVLLLGPLQLCPLLRCAPQTPREPPAAPGAWRQTIQWENNGQVFSLLSLGAQYQPQRRRDPSATARRPDGDAASQPRTPILLLRDNRTASTRARTPSPSGVAAGRPRPAARHWFQAGFSPSGARDGASRRAANRTASPQPPQLSNLRPPSHIDRMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Phosphorylation | RPDGDAASQPRTPIL CCCCCCCCCCCCCEE | 42.30 | 29514104 | |
| 83 | Phosphorylation | DAASQPRTPILLLRD CCCCCCCCCEEEEEC | 22.74 | 29514104 | |
| 91 | N-linked_Glycosylation | PILLLRDNRTASTRA CEEEEECCCCCCCCC | 36.45 | - | |
| 100 | Phosphorylation | TASTRARTPSPSGVA CCCCCCCCCCCCCCC | 27.42 | 26824392 | |
| 102 | Phosphorylation | STRARTPSPSGVAAG CCCCCCCCCCCCCCC | 30.96 | 26824392 | |
| 104 | Phosphorylation | RARTPSPSGVAAGRP CCCCCCCCCCCCCCC | 50.68 | 25367039 | |
| 124 | Phosphorylation | HWFQAGFSPSGARDG HHHHCCCCCCCCCCC | 19.76 | 25367039 | |
| 126 | Phosphorylation | FQAGFSPSGARDGAS HHCCCCCCCCCCCHH | 43.84 | 25367039 | |
| 133 | Phosphorylation | SGARDGASRRAANRT CCCCCCHHHHHHHCC | 28.03 | 25367039 | |
| 138 | N-linked_Glycosylation | GASRRAANRTASPQP CHHHHHHHCCCCCCC | 40.63 | - | |
| 142 | Phosphorylation | RAANRTASPQPPQLS HHHHCCCCCCCCCHH | 24.37 | 25338131 | |
| 181 | Sulfation | DNPYYNYYDTYERPR CCCCCCCCCCCCCCC | 9.73 | - | |
| 322 | Phosphorylation | ASFCLEDTSCDYGYH CEEECCCCCCCCCCC | 23.14 | - | |
| 323 | Phosphorylation | SFCLEDTSCDYGYHR EEECCCCCCCCCCCC | 19.81 | - | |
| 326 | Phosphorylation | LEDTSCDYGYHRRFA CCCCCCCCCCCCCEE | 24.74 | - | |
| 328 | Phosphorylation | DTSCDYGYHRRFACT CCCCCCCCCCCEECC | 5.97 | - | |
| 349 | "2',4',5'-topaquinone" | SPGCYDTYAADIDCQ CCCCCCCCCCCCCCE | 9.26 | - | |
| 349 | Other | SPGCYDTYAADIDCQ CCCCCCCCCCCCCCE | 9.26 | - | |
| 409 | Phosphorylation | YASGCTISPY----- EECCCEEECC----- | 10.45 | 29514104 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LYOX_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LYOX_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LYOX_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LYOX_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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