PSB4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB4_MOUSE
• UniProt AC: P99026
• Protein Name: Proteasome subunit beta type-4
• Gene Name: Psmb4
• Organism: Mus musculus (Mouse).
• Sequence Length: 264
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1..
• Protein Sequence: MEAFWESRAGHWAGGPAPGQFYRIPATPSGLMDPASAPCEGPITRTQNPMVTGTSVLGVKFDGGVVIAADMLGSYGSLARFRNISRIMRVNDSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSAQTNWDIAHMISGFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAFWESR -------CCCCCCCC	8.27	-
46	Phosphorylation	CEGPITRTQNPMVTG CCCCCCCCCCCCCCC	24.85	22817900
93	Phosphorylation	RIMRVNDSTMLGASG HHEEECCCCCCCCCC	15.54	18579562
94	Phosphorylation	IMRVNDSTMLGASGD HEEECCCCCCCCCCC	21.19	25367039
99	Phosphorylation	DSTMLGASGDYADFQ CCCCCCCCCCHHHHH	30.33	26160508
102	Phosphorylation	MLGASGDYADFQYLK CCCCCCCHHHHHHHH	16.17	26160508
107	Phosphorylation	GDYADFQYLKQVLGQ CCHHHHHHHHHHHCC	18.83	26643407
127	Phosphorylation	ELLGDGHSYSPRAIH HHCCCCCCCCHHHHH	32.60	26745281
128	Phosphorylation	LLGDGHSYSPRAIHS HCCCCCCCCHHHHHH	19.61	26745281
129	Phosphorylation	LGDGHSYSPRAIHSW CCCCCCCCHHHHHHH	15.78	26745281
201	Acetylation	LLREVLEKQPVLSQT HHHHHHHHCCCCCHH	56.60	22826441
201	Ubiquitination	LLREVLEKQPVLSQT HHHHHHHHCCCCCHH	56.60	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA2_HUMAN	PSMA2	physical	17139257
PSDE_MOUSE	Psmd14	physical	17139257
CDK18_HUMAN	CDK18	physical	26496610
PSA1_HUMAN	PSMA1	physical	26496610
PSA2_HUMAN	PSMA2	physical	26496610
PSA3_HUMAN	PSMA3	physical	26496610
PSA4_HUMAN	PSMA4	physical	26496610
PSA5_HUMAN	PSMA5	physical	26496610
PSA6_HUMAN	PSMA6	physical	26496610
PSA7_HUMAN	PSMA7	physical	26496610
PSB1_HUMAN	PSMB1	physical	26496610
PSB2_HUMAN	PSMB2	physical	26496610
PSB3_HUMAN	PSMB3	physical	26496610
PSB5_HUMAN	PSMB5	physical	26496610
PSB6_HUMAN	PSMB6	physical	26496610
PSB7_HUMAN	PSMB7	physical	26496610
PRS4_HUMAN	PSMC1	physical	26496610
PRS7_HUMAN	PSMC2	physical	26496610
PRS6A_HUMAN	PSMC3	physical	26496610
PRS8_HUMAN	PSMC5	physical	26496610
PRS10_HUMAN	PSMC6	physical	26496610
PSMD1_HUMAN	PSMD1	physical	26496610
PSMD3_HUMAN	PSMD3	physical	26496610
PSMD4_HUMAN	PSMD4	physical	26496610
PSME1_HUMAN	PSME1	physical	26496610
PSME2_HUMAN	PSME2	physical	26496610
SMCA4_HUMAN	SMARCA4	physical	26496610
PSMG1_HUMAN	PSMG1	physical	26496610
ATP9A_HUMAN	ATP9A	physical	26496610
PSME3_HUMAN	PSME3	physical	26496610
PSDE_HUMAN	PSMD14	physical	26496610
ADRM1_HUMAN	ADRM1	physical	26496610
HPS5_HUMAN	HPS5	physical	26496610
DNJC8_HUMAN	DNAJC8	physical	26496610
FNBP4_HUMAN	FNBP4	physical	26496610
FBX7_HUMAN	FBXO7	physical	26496610
RNC_HUMAN	DROSHA	physical	26496610
AKIR2_HUMAN	AKIRIN2	physical	26496610
PSMG2_HUMAN	PSMG2	physical	26496610
TM109_HUMAN	TMEM109	physical	26496610
F192A_HUMAN	FAM192A	physical	26496610
CE120_HUMAN	CEP120	physical	26496610
SPAT5_HUMAN	SPATA5	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.