PSDE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSDE_MOUSE
• UniProt AC: O35593
• Protein Name: 26S proteasome non-ATPase regulatory subunit 14
• Gene Name: Psmd14
• Organism: Mus musculus (Mouse).
• Sequence Length: 310
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading..
• Protein Sequence: MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	VDTAEQVYISSLALL CCCHHHHHHHHHHHH	8.52	22817900
150	Phosphorylation	VVVDPIQSVKGKVVI EEECCHHHCCCEEEE	26.90	17693683
152	Ubiquitination	VDPIQSVKGKVVIDA ECCHHHCCCEEEEEH	59.26	27667366
224	Phosphorylation	LLNLHKKSWMEGLTL HHHHHHHCHHCCCCH	36.14	24719451
243	Phosphorylation	EHCKHNESVVKEMLE HHHCCCHHHHHHHHH	37.21	25159016
246	Ubiquitination	KHNESVVKEMLELAK CCCHHHHHHHHHHHH	34.94	-
255	Phosphorylation	MLELAKNYNKAVEEE HHHHHHHHHHHHHHH	19.82	25159016
257	Ubiquitination	ELAKNYNKAVEEEDK HHHHHHHHHHHHHHC	43.37	27667366
264	Acetylation	KAVEEEDKMTPEQLA HHHHHHHCCCHHHHH	48.21	23954790
266	Phosphorylation	VEEEDKMTPEQLAIK HHHHHCCCHHHHHHH	29.43	-
273	Ubiquitination	TPEQLAIKNVGKQDP CHHHHHHHCCCCCCH	39.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSDE_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSDE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSDE_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA2_HUMAN	PSMA2	physical	17139257
ADRM1_HUMAN	ADRM1	physical	17139257
PRS8_MOUSE	Psmc5	physical	21883213
PSB5_MOUSE	Psmb5	physical	21883213

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.