PSB7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSB7_MOUSE
• UniProt AC: P70195
• Protein Name: Proteasome subunit beta type-7
• Gene Name: Psmb7
• Organism: Mus musculus (Mouse).
• Sequence Length: 277
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity..
• Protein Sequence: MAAVSVFQPPVGGFSFDNCRRNAVLEADFAKKGFKLPKARKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLEIEVLEETVQTMDTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	QPPVGGFSFDNCRRN CCCCCCCCCCCCCCC	34.66	26643407
31	Ubiquitination	VLEADFAKKGFKLPK CHHHHHHHCCCCCCC	54.12	27667366
52	Ubiquitination	TIAGVVYKDGIVLGA EEEEEEECCCEEEEC	37.56	-
72	Acetylation	EGMVVADKNCSKIHF CCCEEECCCCCEEEE	50.55	22826441
72	Ubiquitination	EGMVVADKNCSKIHF CCCEEECCCCCEEEE	50.55	-
74	S-nitrosocysteine	MVVADKNCSKIHFIS CEEECCCCCEEEEEC	5.59	-
74	Glutathionylation	MVVADKNCSKIHFIS CEEECCCCCEEEEEC	5.59	24333276
74	S-nitrosylation	MVVADKNCSKIHFIS CEEECCCCCEEEEEC	5.59	21278135
121	Phosphorylation	GRLPRVVTANRMLKQ CCCCHHHCHHHHHHH	18.50	-
154	Phosphorylation	DVTGPHLYSIYPHGS CCCCCCEEEECCCCC	7.03	22817900
195	Acetylation	DMEEEEAKKLVSEAI CCCHHHHHHHHHHHH	50.33	23954790
195	Ubiquitination	DMEEEEAKKLVSEAI CCCHHHHHHHHHHHH	50.33	-
196	Ubiquitination	MEEEEAKKLVSEAIA CCHHHHHHHHHHHHH	62.26	-
224	Phosphorylation	DLCVISKSKLDFLRP EEEEEECHHCCEECC	31.49	-
225	Ubiquitination	LCVISKSKLDFLRPF EEEEECHHCCEECCC	56.67	-
233	Phosphorylation	LDFLRPFSVPNKKGT CCEECCCCCCCCCCC	39.07	23684622
237	Ubiquitination	RPFSVPNKKGTRLGR CCCCCCCCCCCCEEE	46.65	27667366
237	Acetylation	RPFSVPNKKGTRLGR CCCCCCCCCCCCEEE	46.65	7744099
249	Malonylation	LGRYRCEKGTTAVLT EEEEECCCCCEEEEE	66.25	32601280
273	Phosphorylation	VLEETVQTMDTS--- HHHHHHHHCCCC---	16.81	26643407
276	Phosphorylation	ETVQTMDTS------ HHHHHCCCC------	26.05	26643407
277	Phosphorylation	TVQTMDTS------- HHHHCCCC-------	33.68	28418008

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSB7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSB7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSB7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSB7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.