PSA7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA7_MOUSE
• UniProt AC: Q9Z2U0
• Protein Name: Proteasome subunit alpha type-7
• Gene Name: Psma7
• Organism: Mus musculus (Mouse).
• Sequence Length: 248
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)..
• Protein Sequence: MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDDAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYDRAITV ------CCCCEEEEE	35.42	26745281
3	Phosphorylation	-----MSYDRAITVF -----CCCCEEEEEE	14.24	23984901
8	Phosphorylation	MSYDRAITVFSPDGH CCCCEEEEEECCCCC	17.95	23984901
11	Phosphorylation	DRAITVFSPDGHLFQ CEEEEEECCCCCEEE	20.11	26745281
21	Phosphorylation	GHLFQVEYAQEAVKK CCEEEHHHHHHHHHH	18.09	26745281
27	Ubiquitination	EYAQEAVKKGSTAVG HHHHHHHHHCCCEEE	59.47	-
27	Acetylation	EYAQEAVKKGSTAVG HHHHHHHHHCCCEEE	59.47	-
28	Malonylation	YAQEAVKKGSTAVGV HHHHHHHHCCCEEEC	52.04	26320211
30	Phosphorylation	QEAVKKGSTAVGVRG HHHHHHCCCEEECCC	23.28	23684622
31	Phosphorylation	EAVKKGSTAVGVRGK HHHHHCCCEEECCCC	33.75	22817900
38	Ubiquitination	TAVGVRGKDIVVLGV CEEECCCCEEEEEEE	33.45	-
49	Phosphorylation	VLGVEKKSVAKLQDE EEEECCCCHHHCCCH	38.07	24719451
52	Acetylation	VEKKSVAKLQDERTV ECCCCHHHCCCHHHH	44.52	66694397
52	Malonylation	VEKKSVAKLQDERTV ECCCCHHHCCCHHHH	44.52	26320211
63	S-nitrosocysteine	ERTVRKICALDDNVC HHHHHHHEECCCCEE	3.27	-
63	S-nitrosylation	ERTVRKICALDDNVC HHHHHHHEECCCCEE	3.27	20925432
63	Glutathionylation	ERTVRKICALDDNVC HHHHHHHEECCCCEE	3.27	24333276
70	Glutathionylation	CALDDNVCMAFAGLT EECCCCEEEHHCCCC	1.72	24333276
97	Phosphorylation	ECQSHRLTVEDPVTV EEECCCEECCCCCHH	23.08	18579562
115	Ubiquitination	TRYIASLKQRYTQSN HHHHHHHHHHHHHCC	30.18	-
130	O-linked_Glycosylation	GRRPFGISALIVGFD CCCCCCEEEEEEEEC	19.87	22556278
153	Phosphorylation	QTDPSGTYHAWKANA EECCCCCCEEHHHCC	7.96	-
157	Ubiquitination	SGTYHAWKANAIGRG CCCCEEHHHCCCCCC	32.33	-
167	Phosphorylation	AIGRGAKSVREFLEK CCCCCHHHHHHHHHH	26.35	20469934
174	Ubiquitination	SVREFLEKNYTDDAI HHHHHHHHCCCCCCC	58.35	-
174	Acetylation	SVREFLEKNYTDDAI HHHHHHHHCCCCCCC	58.35	23954790
201	Phosphorylation	ALLEVVQSGGKNIEL HHHHHHHCCCCEEEE	37.59	27180971
204	Ubiquitination	EVVQSGGKNIELAVM HHHHCCCCEEEEEEE	59.27	-
227	Acetylation	LNPEEIEKYVAEIEK CCHHHHHHHHHHHHH	51.16	22826441
227	Ubiquitination	LNPEEIEKYVAEIEK CCHHHHHHHHHHHHH	51.16	-
234	Acetylation	KYVAEIEKEKEENEK HHHHHHHHHHHHHHH	78.66	23954790
234	Ubiquitination	KYVAEIEKEKEENEK HHHHHHHHHHHHHHH	78.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
153	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot
153	Y	Phosphorylation	Kinase	ABL2	Q4JIM5	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAVS_MOUSE	Mavs	physical	21425308

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.