CASA1_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASA1_BOVIN
• UniProt AC: P02662
• Protein Name: Alpha-S1-casein
• Gene Name: CSN1S1
• Organism: Bos taurus (Bovine).
• Sequence Length: 214
• Subcellular Localization: Secreted.
• Protein Description: Important role in the capacity of milk to transport calcium phosphate.; Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity..
• Protein Sequence: MKLLILTCLVAVALARPKHPIKHQGLPQEVLNENLLRFFVAPFPEVFGKEKVNELSKDIGSESTEDQAMEDIKQMEAESISSSEEIVPNSVEQKHIQKEDVPSERYLGYLEQLLRLKKYKVPQLEIVPNSAEERLHSMKEGIHAQQKEPMIGVNQELAYFYPELFRQFYQLDAYPSGAWYYVPLGTQYTDAPSFSDIPNPIGSENSEKTTMPLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	KEKVNELSKDIGSES HHHHHHHHHHCCCCC	23.31	15858219
61	Phosphorylation	ELSKDIGSESTEDQA HHHHHCCCCCCHHHH	28.80	29541418
63	Phosphorylation	SKDIGSESTEDQAME HHHCCCCCCHHHHHH	38.50	29541418
64	Phosphorylation	KDIGSESTEDQAMED HHCCCCCCHHHHHHH	39.26	29541418
79	Phosphorylation	IKQMEAESISSSEEI HHHHHHHHCCCCCCC	34.51	15858219
81	Phosphorylation	QMEAESISSSEEIVP HHHHHHCCCCCCCCC	36.77	15858219
82	Phosphorylation	MEAESISSSEEIVPN HHHHHCCCCCCCCCC	39.85	15858219
83	Phosphorylation	EAESISSSEEIVPNS HHHHCCCCCCCCCCC	32.24	15858219
90	Phosphorylation	SEEIVPNSVEQKHIQ CCCCCCCCHHHHCCC	22.44	15858219
130	Phosphorylation	QLEIVPNSAEERLHS CEEECCCCHHHHHHH	30.87	28710545

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
56	S	Phosphorylation	Kinase	CK1-FAMILY	-	GPS
56	S	Phosphorylation	Kinase	CK1_GROUP	-	PhosphoELM
61	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
61	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
63	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
63	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
64	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
64	T	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASA1_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASA1_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of CASA1_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Highly selective enrichment of phosphorylated peptides from peptidemixtures using titanium dioxide microcolumns.";
Larsen M.R., Thingholm T.E., Jensen O.N., Roepstorff P.,Jorgensen T.J.;
Mol. Cell. Proteomics 4:873-886(2005).
Cited for: PHOSPHORYLATION AT SER-56; SER-61; SER-63; SER-79; SER-81; SER-82;SER-83; SER-90 AND SER-130, AND MASS SPECTROMETRY.
PubMed: 15858219