dbPTM

PCM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PCM1_MOUSE
UniProt AC	Q9R0L6
Protein Name	Pericentriolar material 1 protein
Gene Name	Pcm1
Organism	Mus musculus (Mouse).
Sequence Length	2025
Subcellular Localization	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasmic granule . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, cilium basal body . Not
Protein Description	Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins probably including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Probably involved in the biogenesis of cilia..
Protein Sequence	MATGGGPFEEVMHDQDLPNWSNDSVDDRLNNMEWGGQQKKANRSSEKNKKKFGVASDKRVTNAISPESSPGVGRRRTKIPHTFPHSRYMTQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDATASLPKREMTTSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIEHLKEQEKSYMKFLQKILARDPQQEPMEETENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVTETTGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREISQSRNPSVSEHLPDEKVQLFSKMRVLQEKKQKMDKLLGELHNLRDQHLNNSSFVPSTSLQRSGDKRSSTVALSAPVGFASAVNGEANSLISSVPCPATSLVSQNESENEGHLNPAEKLQKLNEVQKRLNELRELVHYYEQTSDMMTDAVNENTKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNTNSNTQCGSNNRDGRPVNSNCEINNRSAANIRALNMPPLDCRYNREGEQRLHVAHGEDEEEEVEEEGVSGASLSSRRSSLVDEAPEDEEFEQKISRLMAAKEKLKQLQDLVAMVQDDDATQVVVPAASNLDDFYAAEEDIKQNSNNARENSNKIDTGVNEKTREKFYEAKLQQQQRELKQLQEERKKLIEIQEKIQAVQKACPDLQLSATSISSGPTKKYLPAITSTPTVNENDSSTSKCVIDPEDSSVVDNELWSDMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETSSPVAISLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFPIYPPSMNQNSYNVKETKTRWKSNRPVSADGNYRPLAKTRQQNISMQRQENLRWVSELSYIEEKEQWQEQINQLKKQLDFSVNICQTLMQDQQTLSCLLQTLLTGPYSVLPSNVASPQVHLIMHQLNQCYTQLTWQQNNVQRLKQMLTELMRQQNQHPEKPRSKERGSSASHPSSPNLFCPFSFPTQPVNLFNLPGFTNFPSFAPGMNFSPLFPSNFGDFSQNVSTPTEQQQPLAQNPSGKTEYMAFPKPFESSSSLGAEKQRNQKQPEEEAENTKTPWLYDQEGGVEKPFFKTGFTESVEKATNSNRKNQPDTSRRRRQFDEESLESFSSMPDPIDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIGYESASVSSTCEPCKNRNRHSAQTEEPVQAKLFSRKNHEQLEKIIKYSRSAEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESDEREGENVKPVNSGTWVASNSELTPSESLVTTDDETFEKNFERETHKVSEQNDADNVSVMSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTETESHSNMRCTCRVIEDEDGAAAAATVSNSEETPIIENHNSPQPISDVSAVPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSIAVKQRCKRKIEAAGVRQSYAKEAKRILEGDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDAKGPKNVRSDVSDQEEDEESERCPVSINLSKAESQALTNYGSGEDENEDEEMEDFEESPVDIQTSLQANTETTEENEHDSQILQHDLEKTPESTNVPSDQEPTSKNDQDSSPVKPCYLNILENEQQLNSATHKDSLTTTDSSKQPEPLPLPLAASETLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTVYSEEELRKKMIEEEQKNHLSGEICEMQTEELAGNSQILKEPETVGAQSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATGGGPFE ------CCCCCCCHH	26.68	-
21	Phosphorylation	DQDLPNWSNDSVDDR CCCCCCCCCCCHHHH	37.08	25293948
24	Phosphorylation	LPNWSNDSVDDRLNN CCCCCCCCHHHHHHH	31.53	25293948
44	O-linked_Glycosylation	QQKKANRSSEKNKKK HHHHCCCCCHHHHHH	42.53	30059200
45	O-linked_Glycosylation	QKKANRSSEKNKKKF HHHCCCCCHHHHHHH	49.72	30059200
56	Phosphorylation	KKKFGVASDKRVTNA HHHHCCCCCHHHHCC	41.06	23737553
61	Phosphorylation	VASDKRVTNAISPES CCCCHHHHCCCCCCC	23.98	27087446
65	Phosphorylation	KRVTNAISPESSPGV HHHHCCCCCCCCCCC	21.87	27087446
68	Phosphorylation	TNAISPESSPGVGRR HCCCCCCCCCCCCCC	45.26	25521595
69	Phosphorylation	NAISPESSPGVGRRR CCCCCCCCCCCCCCC	24.82	25521595
88	Phosphorylation	HTFPHSRYMTQMSVP CCCCCCHHCCCCCCC	13.92	25619855
90	Phosphorylation	FPHSRYMTQMSVPEQ CCCCHHCCCCCCCCH	16.52	25619855
93	Phosphorylation	SRYMTQMSVPEQAEL CHHCCCCCCCCHHHH	25.38	25521595
102	Ubiquitination	PEQAELEKLKQRINF CCHHHHHHHHHHCCC	73.87	-
104	Ubiquitination	QAELEKLKQRINFSD HHHHHHHHHHCCCHH	48.90	-
110	Phosphorylation	LKQRINFSDLDQRSI HHHHCCCHHCCCCCC	32.54	21082442
116	Phosphorylation	FSDLDQRSIGSDSQG CHHCCCCCCCCCHHH	26.18	27087446
119	Phosphorylation	LDQRSIGSDSQGRAT CCCCCCCCCHHHHHH	32.21	27087446
121	Phosphorylation	QRSIGSDSQGRATAA CCCCCCCHHHHHHHH	35.91	27087446
126	Phosphorylation	SDSQGRATAANNKRQ CCHHHHHHHHHCCHH	25.58	26643407
135	Phosphorylation	ANNKRQLSENRKPFN HHCCHHCCCCCCCCC	25.20	-
139	Ubiquitination	RQLSENRKPFNFLPM HHCCCCCCCCCCCCE	66.59	-
157	Phosphorylation	TNKSKDATASLPKRE CCCCCCCCCCCCCCC	27.23	28066266
159	Phosphorylation	KSKDATASLPKREMT CCCCCCCCCCCCCCC	40.63	28066266
180	Phosphorylation	ELFASALSNDLLQNC HHHHHHHCCHHHHHC	28.19	26745281
190	Phosphorylation	LLQNCQVSEEDGRGE HHHHCCCCCCCCCCC	14.91	26745281
202	Phosphorylation	RGEPAMESSQIVSRL CCCCCHHHHHHHHHH	17.92	26745281
203	Phosphorylation	GEPAMESSQIVSRLV CCCCHHHHHHHHHHH	15.60	26745281
259	Ubiquitination	SYMKFLQKILARDPQ HHHHHHHHHHCCCCC	41.66	-
259 (in isoform 2)	Ubiquitination	-	41.66	-
277	Ubiquitination	MEETENLKKQHDLLK HHHHHHHHHHHHHHH	63.07	-
278	Ubiquitination	EETENLKKQHDLLKR HHHHHHHHHHHHHHH	56.91	-
309	Ubiquitination	ALLALQHKAEQAIAV HHHHHHHHHHHHHHC	40.43	-
356	Phosphorylation	FHNQLRDSQPPAVPD HHHHHHHCCCCCCCC	37.85	28066266
370	Phosphorylation	DNRRQAESLSLTREI CCHHHHHHHHHHHHH	26.69	28066266
372	Phosphorylation	RRQAESLSLTREISQ HHHHHHHHHHHHHHH	36.65	22006019
374	Phosphorylation	QAESLSLTREISQSR HHHHHHHHHHHHHCC	23.92	28066266
378	Phosphorylation	LSLTREISQSRNPSV HHHHHHHHHCCCCCH	19.83	26824392
380	Phosphorylation	LTREISQSRNPSVSE HHHHHHHCCCCCHHH	27.51	27087446
384	Phosphorylation	ISQSRNPSVSEHLPD HHHCCCCCHHHCCCH	41.65	27087446
386	O-linked_Glycosylation	QSRNPSVSEHLPDEK HCCCCCHHHCCCHHH	24.52	30059200
386	Phosphorylation	QSRNPSVSEHLPDEK HCCCCCHHHCCCHHH	24.52	27742792
393	Ubiquitination	SEHLPDEKVQLFSKM HHCCCHHHHHHHHHH	42.53	22790023
393 (in isoform 2)	Ubiquitination	-	42.53	22790023
399	Acetylation	EKVQLFSKMRVLQEK HHHHHHHHHHHHHHH	24.32	-
399	Ubiquitination	EKVQLFSKMRVLQEK HHHHHHHHHHHHHHH	24.32	22790023
399 (in isoform 2)	Ubiquitination	-	24.32	22790023
412	Ubiquitination	EKKQKMDKLLGELHN HHHHHHHHHHHHHHH	41.96	-
428	Phosphorylation	RDQHLNNSSFVPSTS HHHHCCCCCCCCCHH	24.87	28066266
429	Phosphorylation	DQHLNNSSFVPSTSL HHHCCCCCCCCCHHC	32.18	28066266
432 (in isoform 2)	Ubiquitination	-	29.85	-
433	Phosphorylation	NNSSFVPSTSLQRSG CCCCCCCCHHCCCCC	25.90	28066266
434	Phosphorylation	NSSFVPSTSLQRSGD CCCCCCCHHCCCCCC	27.64	26060331
435	Phosphorylation	SSFVPSTSLQRSGDK CCCCCCHHCCCCCCC	27.17	28066266
438 (in isoform 2)	Ubiquitination	-	48.15	-
497	Ubiquitination	NPAEKLQKLNEVQKR CHHHHHHHHHHHHHH	64.81	27667366
503	Ubiquitination	QKLNEVQKRLNELRE HHHHHHHHHHHHHHH	65.12	27667366
535	Phosphorylation	ENTKDEETEESEYDS CCCCCCCCCCCCCCC	42.90	23684622
536	Ubiquitination	NTKDEETEESEYDSE CCCCCCCCCCCCCCC	63.91	27667366
538	Phosphorylation	KDEETEESEYDSEHE CCCCCCCCCCCCCCC	34.91	25521595
540	Phosphorylation	EETEESEYDSEHENS CCCCCCCCCCCCCCC	33.76	25293948
542	Phosphorylation	TEESEYDSEHENSEP CCCCCCCCCCCCCCC	39.69	25521595
547	Phosphorylation	YDSEHENSEPVTNIR CCCCCCCCCCCCCCC	40.05	25293948
575	Phosphorylation	NSNTQCGSNNRDGRP CCCCCCCCCCCCCCC	38.26	25338131
593	Phosphorylation	NCEINNRSAANIRAL CCEECCCCHHCHHHH	33.58	-
635	Phosphorylation	EVEEEGVSGASLSSR HHHHHCCCCCCHHHH	39.23	25619855
638	Phosphorylation	EEGVSGASLSSRRSS HHCCCCCCHHHHHHH	32.10	25619855
640	Phosphorylation	GVSGASLSSRRSSLV CCCCCCHHHHHHHCC	21.21	25619855
641	Phosphorylation	VSGASLSSRRSSLVD CCCCCHHHHHHHCCC	36.69	25619855
644	Phosphorylation	ASLSSRRSSLVDEAP CCHHHHHHHCCCCCC	27.24	25521595
645	Phosphorylation	SLSSRRSSLVDEAPE CHHHHHHHCCCCCCC	30.51	25521595
707	Ubiquitination	YAAEEDIKQNSNNAR HHHHHHHHHCCCCCC	56.61	-
708	Ubiquitination	AAEEDIKQNSNNARE HHHHHHHHCCCCCCH	59.94	27667366
719	Ubiquitination	NARENSNKIDTGVNE CCCHHCCCCCCCCCH	41.60	-
727	Ubiquitination	IDTGVNEKTREKFYE CCCCCCHHHHHHHHH	47.91	27667366
733	Phosphorylation	EKTREKFYEAKLQQQ HHHHHHHHHHHHHHH	26.50	25367039
733	Ubiquitination	EKTREKFYEAKLQQQ HHHHHHHHHHHHHHH	26.50	27667366
736	Ubiquitination	REKFYEAKLQQQQRE HHHHHHHHHHHHHHH	34.58	-
760	Ubiquitination	KLIEIQEKIQAVQKA HHHHHHHHHHHHHHH	24.60	-
766	Ubiquitination	EKIQAVQKACPDLQL HHHHHHHHHCCCCCC	45.41	27667366
774	Phosphorylation	ACPDLQLSATSISSG HCCCCCCCCEECCCC	19.28	26643407
776	Phosphorylation	PDLQLSATSISSGPT CCCCCCCEECCCCCC	24.18	26745281
777	O-linked_Glycosylation	DLQLSATSISSGPTK CCCCCCEECCCCCCC	21.86	30059200
777	Phosphorylation	DLQLSATSISSGPTK CCCCCCEECCCCCCC	21.86	26745281
779	Phosphorylation	QLSATSISSGPTKKY CCCCEECCCCCCCCC	29.07	26745281
780	Phosphorylation	LSATSISSGPTKKYL CCCEECCCCCCCCCC	47.31	26745281
783	Phosphorylation	TSISSGPTKKYLPAI EECCCCCCCCCCCCC	43.63	26643407
785	Ubiquitination	ISSGPTKKYLPAITS CCCCCCCCCCCCCCC	55.27	-
786	Phosphorylation	SSGPTKKYLPAITST CCCCCCCCCCCCCCC	21.34	25619855
791	Phosphorylation	KKYLPAITSTPTVNE CCCCCCCCCCCCCCC	28.75	25619855
792	Phosphorylation	KYLPAITSTPTVNEN CCCCCCCCCCCCCCC	26.69	25619855
793	Phosphorylation	YLPAITSTPTVNEND CCCCCCCCCCCCCCC	17.83	25619855
795	Phosphorylation	PAITSTPTVNENDSS CCCCCCCCCCCCCCC	35.73	25619855
801	Phosphorylation	PTVNENDSSTSKCVI CCCCCCCCCCCCEEE	47.28	25521595
802	Phosphorylation	TVNENDSSTSKCVID CCCCCCCCCCCEEEC	39.29	25619855
803	Phosphorylation	VNENDSSTSKCVIDP CCCCCCCCCCEEECC	35.84	21082442
804	Phosphorylation	NENDSSTSKCVIDPE CCCCCCCCCEEECCC	26.46	25619855
813	Phosphorylation	CVIDPEDSSVVDNEL EEECCCCCCCCCHHH	24.30	28066266
814	Phosphorylation	VIDPEDSSVVDNELW EECCCCCCCCCHHHH	38.18	28066266
822	Phosphorylation	VVDNELWSDMRRHEM CCCHHHHHHHHHHHH	33.87	28066266
857	Phosphorylation	RRQGLAETSSPVAIS HHCCCCCCCCCEEEE	28.97	25168779
858	Phosphorylation	RQGLAETSSPVAISL HCCCCCCCCCEEEEE	24.93	25168779
859	Phosphorylation	QGLAETSSPVAISLR CCCCCCCCCEEEEEC	30.71	26824392
864	Phosphorylation	TSSPVAISLRSDGSE CCCCEEEEECCCCCC	14.16	21082442
867	Phosphorylation	PVAISLRSDGSENLC CEEEEECCCCCCCCC	52.17	23527152
870	Phosphorylation	ISLRSDGSENLCTPQ EEECCCCCCCCCCCC	28.44	27742792
875	Phosphorylation	DGSENLCTPQQSRTE CCCCCCCCCCCCCCC	27.57	25619855
879	Phosphorylation	NLCTPQQSRTEKTMA CCCCCCCCCCCCCCC	35.60	28059163
952	Phosphorylation	ETKTRWKSNRPVSAD CCCCCCCCCCCCCCC	30.98	25159016
957	Phosphorylation	WKSNRPVSADGNYRP CCCCCCCCCCCCCCC	24.27	26824392
962	Phosphorylation	PVSADGNYRPLAKTR CCCCCCCCCCCHHHH	21.09	25159016
967	Ubiquitination	GNYRPLAKTRQQNIS CCCCCCHHHHHHHHC	52.50	-
968	Phosphorylation	NYRPLAKTRQQNISM CCCCCHHHHHHHHCH	28.27	21659604
974	Phosphorylation	KTRQQNISMQRQENL HHHHHHHCHHHHHHH	19.20	22006019
985	Phosphorylation	QENLRWVSELSYIEE HHHHHHHHHHHHHHH	26.34	19060867
988	Phosphorylation	LRWVSELSYIEEKEQ HHHHHHHHHHHHHHH	21.73	21082442
989	Phosphorylation	RWVSELSYIEEKEQW HHHHHHHHHHHHHHH	25.61	28066266
1070	Ubiquitination	TWQQNNVQRLKQMLT HHHHHHHHHHHHHHH	47.30	27667366
1073	Ubiquitination	QNNVQRLKQMLTELM HHHHHHHHHHHHHHH	35.53	22790023
1073 (in isoform 2)	Ubiquitination	-	35.53	22790023
1089	Ubiquitination	QQNQHPEKPRSKERG HHCCCCCCCCCCCCC	50.62	27667366
1095	Ubiquitination	EKPRSKERGSSASHP CCCCCCCCCCCCCCC	54.77	27667366
1112 (in isoform 2)	Ubiquitination	-	18.56	-
1128	Ubiquitination	FNLPGFTNFPSFAPG CCCCCCCCCCCCCCC	44.57	27667366
1171	Ubiquitination	AQNPSGKTEYMAFPK CCCCCCCCCEEECCC	35.55	27667366
1173	Phosphorylation	NPSGKTEYMAFPKPF CCCCCCCEEECCCCC	10.04	25367039
1178	Ubiquitination	TEYMAFPKPFESSSS CCEEECCCCCCCCHH	56.75	22790023
1178 (in isoform 2)	Ubiquitination	-	56.75	22790023
1182	Phosphorylation	AFPKPFESSSSLGAE ECCCCCCCCHHHCHH	35.58	21082442
1183	Phosphorylation	FPKPFESSSSLGAEK CCCCCCCCHHHCHHH	19.42	21082442
1184	Phosphorylation	PKPFESSSSLGAEKQ CCCCCCCHHHCHHHH	38.57	21082442
1185	Phosphorylation	KPFESSSSLGAEKQR CCCCCCHHHCHHHHH	32.54	21082442
1190	Ubiquitination	SSSLGAEKQRNQKQP CHHHCHHHHHHCCCH	54.76	22790023
1190 (in isoform 2)	Ubiquitination	-	54.76	22790023
1196	Ubiquitination	EKQRNQKQPEEEAEN HHHHHCCCHHHHHHH	40.65	27667366
1205	Ubiquitination	EEEAENTKTPWLYDQ HHHHHHCCCCCEECC	65.26	-
1217 (in isoform 2)	Ubiquitination	-	59.28	-
1226	Phosphorylation	PFFKTGFTESVEKAT CCCCCCCHHHHHHHH	28.79	23984901
1228	Phosphorylation	FKTGFTESVEKATNS CCCCCHHHHHHHHCC	32.30	26824392
1229	Ubiquitination	KTGFTESVEKATNSN CCCCHHHHHHHHCCC	7.72	27667366
1229 (in isoform 2)	Ubiquitination	-	7.72	-
1254	Phosphorylation	RRQFDEESLESFSSM HHHCCHHHHHHHHCC	35.08	21082442
1257	Phosphorylation	FDEESLESFSSMPDP CCHHHHHHHHCCCCC	35.40	21082442
1259	Phosphorylation	EESLESFSSMPDPID HHHHHHHHCCCCCCC	34.70	21082442
1260	Phosphorylation	ESLESFSSMPDPIDP HHHHHHHCCCCCCCC	32.12	21082442
1268	Phosphorylation	MPDPIDPTTVTKTFK CCCCCCCCCCCCCHH	30.10	25293948
1269	Phosphorylation	PDPIDPTTVTKTFKT CCCCCCCCCCCCHHC	31.40	26643407
1271	Phosphorylation	PIDPTTVTKTFKTRK CCCCCCCCCCHHCCC	23.44	26643407
1280	Phosphorylation	TFKTRKASAQASLAS CHHCCCHHHHHHHHC	24.77	26824392
1284	Phosphorylation	RKASAQASLASKDKT CCHHHHHHHHCCCCC	16.64	28066266
1287	Phosphorylation	SAQASLASKDKTPKS HHHHHHHCCCCCCCC	46.83	28066266
1301	Phosphorylation	SKSKKRNSTQLKSRV CHHHCCCHHHHHHHH	22.89	22324799
1302	Phosphorylation	KSKKRNSTQLKSRVK HHHCCCHHHHHHHHH	41.28	22324799
1309	Ubiquitination	TQLKSRVKNIGYESA HHHHHHHHHHCCCCC	41.56	-
1313	Phosphorylation	SRVKNIGYESASVSS HHHHHHCCCCCCCCC	11.69	28066266
1315	Phosphorylation	VKNIGYESASVSSTC HHHHCCCCCCCCCCC	19.84	25266776
1317	Phosphorylation	NIGYESASVSSTCEP HHCCCCCCCCCCCCC	31.63	19060867
1319	Phosphorylation	GYESASVSSTCEPCK CCCCCCCCCCCCCCC	19.89	21183079
1320	Phosphorylation	YESASVSSTCEPCKN CCCCCCCCCCCCCCC	34.62	19060867
1321	Phosphorylation	ESASVSSTCEPCKNR CCCCCCCCCCCCCCC	17.24	21183079
1326	Ubiquitination	SSTCEPCKNRNRHSA CCCCCCCCCCCCCCC	70.43	-
1332	Phosphorylation	CKNRNRHSAQTEEPV CCCCCCCCCCCCCCH	20.87	30635358
1335	Phosphorylation	RNRHSAQTEEPVQAK CCCCCCCCCCCHHHH	41.87	22210690
1359	Phosphorylation	LEKIIKYSRSAEISS HHHHHHHHHHCCCCC	18.11	24719451
1361	Phosphorylation	KIIKYSRSAEISSET HHHHHHHHCCCCCCC	25.06	28066266
1365	Phosphorylation	YSRSAEISSETGSDF HHHHCCCCCCCCCCC	17.39	21743459
1366	Phosphorylation	SRSAEISSETGSDFS HHHCCCCCCCCCCCH	44.85	21743459
1368	Phosphorylation	SAEISSETGSDFSMF HCCCCCCCCCCCHHH	43.89	28066266
1370	Phosphorylation	EISSETGSDFSMFEA CCCCCCCCCCHHHHH	42.79	21743459
1373	Phosphorylation	SETGSDFSMFEALRD CCCCCCCHHHHHHHH	27.79	28066266
1428	Phosphorylation	YALQDIVSRHISESD HHHHHHHHHHCCCCC	20.62	26824392
1432	Phosphorylation	DIVSRHISESDEREG HHHHHHCCCCCCCCC	25.56	25521595
1434	Phosphorylation	VSRHISESDEREGEN HHHHCCCCCCCCCCC	37.67	25521595
1447	Phosphorylation	ENVKPVNSGTWVASN CCCCCCCCCCEEECC	37.52	25293948
1449	Phosphorylation	VKPVNSGTWVASNSE CCCCCCCCEEECCCC	19.31	25293948
1453	Phosphorylation	NSGTWVASNSELTPS CCCCEEECCCCCCCC	31.13	25293948
1455	Phosphorylation	GTWVASNSELTPSES CCEEECCCCCCCCHH	31.33	25293948
1458	Phosphorylation	VASNSELTPSESLVT EECCCCCCCCHHCCC	22.25	25195567
1460	Phosphorylation	SNSELTPSESLVTTD CCCCCCCCHHCCCCC	34.28	25293948
1462	Phosphorylation	SELTPSESLVTTDDE CCCCCCHHCCCCCHH	32.26	25195567
1465	Phosphorylation	TPSESLVTTDDETFE CCCHHCCCCCHHHHH	29.78	25293948
1466	Phosphorylation	PSESLVTTDDETFEK CCHHCCCCCHHHHHH	33.69	25293948
1470	Phosphorylation	LVTTDDETFEKNFER CCCCCHHHHHHHHHH	44.05	25293948
1483	Phosphorylation	ERETHKVSEQNDADN HHHHHCCCCCCCCCC	37.96	25293948
1492	Phosphorylation	QNDADNVSVMSVSSN CCCCCCEEEEEECCC	20.54	26643407
1495	Phosphorylation	ADNVSVMSVSSNFEP CCCEEEEEECCCCCC	19.38	26643407
1497	Phosphorylation	NVSVMSVSSNFEPFA CEEEEEECCCCCCCC	16.56	26643407
1498	Phosphorylation	VSVMSVSSNFEPFAT EEEEEECCCCCCCCC	43.30	26643407
1505	Phosphorylation	SNFEPFATDDLGNTV CCCCCCCCCCCCCCE	30.35	25293948
1511	Phosphorylation	ATDDLGNTVIHLDQA CCCCCCCCEEHHHHH	21.02	25293948
1556	Phosphorylation	DGAAAAATVSNSEET CCCEEEEEECCCCCC	21.53	26239621
1558	Phosphorylation	AAAAATVSNSEETPI CEEEEEECCCCCCCC	30.22	26239621
1560	Phosphorylation	AAATVSNSEETPIIE EEEEECCCCCCCCCC	29.33	26239621
1563	Phosphorylation	TVSNSEETPIIENHN EECCCCCCCCCCCCC	18.75	26239621
1571	Phosphorylation	PIIENHNSPQPISDV CCCCCCCCCCCCCCC	19.84	27087446
1576	Phosphorylation	HNSPQPISDVSAVPC CCCCCCCCCCCCCCC	38.35	26160508
1579	Phosphorylation	PQPISDVSAVPCPRI CCCCCCCCCCCCCCC	28.65	26160508
1649	Phosphorylation	FFHKQLGSILQDSLA HHHHHHHHHHHHHHH	28.81	28418008
1654	Phosphorylation	LGSILQDSLAKFAGR HHHHHHHHHHHHCCH	19.77	19144319
1695	Phosphorylation	MQDLDNNSIAVKQRC HHHCCCCCHHHHHHH	20.41	28066266
1714	Phosphorylation	EAAGVRQSYAKEAKR HHHCCHHHHHHHHHH	19.25	25338131
1729	Phosphorylation	ILEGDHGSPAGEIDD HHCCCCCCCCCCCCC	14.25	25521595
1766	Phosphorylation	KGPKNVRSDVSDQEE CCCCCCCCCCCCCCC	37.77	25521595
1769	Phosphorylation	KNVRSDVSDQEEDEE CCCCCCCCCCCCCHH	38.27	27087446
1777	Phosphorylation	DQEEDEESERCPVSI CCCCCHHHHCCCEEE	28.44	25521595
1783	Phosphorylation	ESERCPVSINLSKAE HHHCCCEEEECCHHH	7.30	25168779
1787	Phosphorylation	CPVSINLSKAESQAL CCEEEECCHHHHHHH	25.90	25619855
1847	Phosphorylation	LQHDLEKTPESTNVP HHHHHHHCCCCCCCC	23.94	25619855
1850	Phosphorylation	DLEKTPESTNVPSDQ HHHHCCCCCCCCCCC	26.87	25619855
1851	Phosphorylation	LEKTPESTNVPSDQE HHHCCCCCCCCCCCC	38.28	25619855
1855	Phosphorylation	PESTNVPSDQEPTSK CCCCCCCCCCCCCCC	47.87	25521595
1860	Phosphorylation	VPSDQEPTSKNDQDS CCCCCCCCCCCCCCC	52.13	25619855
1861	Phosphorylation	PSDQEPTSKNDQDSS CCCCCCCCCCCCCCC	39.93	25619855
1867	Phosphorylation	TSKNDQDSSPVKPCY CCCCCCCCCCCCCCC	30.79	28418008
1868	Phosphorylation	SKNDQDSSPVKPCYL CCCCCCCCCCCCCCH	41.84	21082442
1874	Phosphorylation	SSPVKPCYLNILENE CCCCCCCCHHHHHCH	16.00	21659605
1886	Phosphorylation	ENEQQLNSATHKDSL HCHHHHCCCCCCCCC	43.04	22802335
1924	Phosphorylation	PRVKEVKSAQETPES CCHHHHHCCCCCCCH	40.12	25293948
1928	Phosphorylation	EVKSAQETPESSLAG HHHCCCCCCCHHCCC	21.92	25293948
1931	Phosphorylation	SAQETPESSLAGSPD CCCCCCCHHCCCCCC	31.68	25293948
1932	Phosphorylation	AQETPESSLAGSPDT CCCCCCHHCCCCCCC	22.15	25293948
1936	Phosphorylation	PESSLAGSPDTESPV CCHHCCCCCCCCCCE	17.62	23737553
1939	Phosphorylation	SLAGSPDTESPVLVN HCCCCCCCCCCEEEC	41.57	25293948
1941	Phosphorylation	AGSPDTESPVLVNDY CCCCCCCCCEEECEE	23.54	23737553
1948	Phosphorylation	SPVLVNDYEAESGNI CCEEECEEECCCCCC	16.31	23737553
1952	Phosphorylation	VNDYEAESGNISQKS ECEEECCCCCCCCCC	44.16	23737553
1956	Phosphorylation	EAESGNISQKSDEED ECCCCCCCCCCCHHH	35.24	23737553
1959	Phosphorylation	SGNISQKSDEEDFVK CCCCCCCCCHHHCEE	42.49	25521595
1978	Phosphorylation	PLKLTVYSEEELRKK CEEEEECCHHHHHHH	33.91	28066266
2024	Phosphorylation	PETVGAQSI------ CCCCCCCCC------	29.72	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PCM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
372	S	Phosphorylation		-
Phosphorylation at Ser-372 mediated by PLK4 is required to maintain the integrity of centriolar satellites (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PCM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BBS4_HUMAN	BBS4	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
MOONR_HUMAN	KIAA0753	physical	26496610
CE350_HUMAN	CEP350	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
DLGP4_HUMAN	DLGAP4	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
EMSY_HUMAN	C11orf30	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
CCD77_HUMAN	CCDC77	physical	26496610
TBC31_HUMAN	TBC1D31	physical	26496610
ADIP_HUMAN	SSX2IP	physical	26496610
FOPNL_HUMAN	FOPNL	physical	26496610
WDR90_HUMAN	WDR90	physical	26496610
CCD61_HUMAN	CCDC61	physical	26496610
OFD1_HUMAN	OFD1	physical	27146717
MIB1_HUMAN	MIB1	physical	27146717
CEP72_HUMAN	CEP72	physical	27146717
PIBF1_HUMAN	PIBF1	physical	27146717
C2CD3_HUMAN	C2CD3	physical	27146717
CP131_HUMAN	CEP131	physical	27146717
CE290_HUMAN	CEP290	physical	27146717

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PCM1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65 AND SER-1654, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-864; SER-1287;SER-1432; SER-1434; SER-1729; SER-1766 AND SER-1769, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-69; SER-1766;SER-1769 AND SER-1777, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations."; Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.; Mol. Cell. Proteomics 6:283-293(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.	17114649 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-1766 ANDSER-1769, AND MASS SPECTROMETRY.	15345747 [Abstract]

show