CP110_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP110_MOUSE
• UniProt AC: Q7TSH4
• Protein Name: Centriolar coiled-coil protein of 110 kDa
• Gene Name: Ccp110
• Organism: Mus musculus (Mouse).
• Sequence Length: 1004
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Recruited early and then associates with the growing dis
• Protein Description: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. [PubMed: 23141541 Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation]
• Protein Sequence: MEEYEEFCEKALGRAQEASLSTGSFLPAQAESVSLIRFHGVAVLSPLLTIEKRKKIQEEKQKALDVQSRKQANRKKALLTRVQEILENVQVRKAPNASDFDQWATETIYSNPEVTDLNVPVRVPNSLPSPTEHCTSVKLEKITGLLPVNNEDQQTPKRVGLPGDSEVSGSLRQCESPESRQAEDGAALRLSSASPQETIISDVLGKEEQDPSCLAEVTPDPYIMSLQNLMKRSKEYVERELSSRSLRNSLKRSVNETHSDRENDAAKASDCVKEKAPPMPIGRHCGSAIPDKPSLNKSNVLLQGASQASSMGTAGLASFSKIDLPAGAAPPAAPDAGSDFTVIPTFVTENKVKSLKGPYAKLPSPEPSMSPTMHRRHSRSASACQILINNPVNACELSPKGKEEAVDRTAPAAAETTNESETVPKSPTDLTGVCSSNVSATKITSESTREMVVGKPSQRQQALGAHLGNNVTVERSAMEGPFIADDRGAQKVDGTCMAVPKLHELQPSSQCVSSQTLEDVCELKSASLLAKNSCNLQMELNKSYDVKHPSPLLTQTQTSRQQMDTPPVFRGNEQFVDNSFEKVKRRLDLDVDSLQKENCPYIITAGVAEQERDRLLERRYPKGFVHINKNKMLETSPKEGQELLKSKMLAFEEMRKRLEEQHAQQLSLLIAEQEREQEQLQKEIEEQEKMLKEKAVTTDVSDLNSALEWRQRTDSALLETMLSQVDSLQTSNNSGFITSALQYSFGSAGEAPFYLWGSLTSGVTRVSGTRPCGRAQAKWSQVFNPEIHAKFNKITAVAKGFLTRKLMQTDKLKQLRQTVKDTMEFIRSFQSEAPLKRGVVSAQDASLQERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREARKEKLLRQMDKMKSPRVALSVATQKSLDRKKFMKVAEMGMPNKKFLLKQNPSETRVLQPNQGQNAPVHRLLSRQGTPKTSVKGVVQNRQKPSQSRVPNRAPVSGAYAGKTQRKRPNVATI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	AVLSPLLTIEKRKKI EEEHHHHHHHHHHHH	34.47	-
126	Phosphorylation	VPVRVPNSLPSPTEH CCEECCCCCCCCCCC	35.27	28066266
129	Phosphorylation	RVPNSLPSPTEHCTS ECCCCCCCCCCCCCC	50.15	28066266
131	Phosphorylation	PNSLPSPTEHCTSVK CCCCCCCCCCCCCCE	42.57	28066266
135	Phosphorylation	PSPTEHCTSVKLEKI CCCCCCCCCCEEEEE	38.16	28066266
136	Phosphorylation	SPTEHCTSVKLEKIT CCCCCCCCCEEEEEC	23.73	28066266
155	Phosphorylation	VNNEDQQTPKRVGLP CCCCCCCCCCCCCCC	25.74	28066266
170	Phosphorylation	GDSEVSGSLRQCESP CCCCCCCCCEECCCC	16.93	-
176	Phosphorylation	GSLRQCESPESRQAE CCCEECCCCCHHHCC	41.41	29514104
191	Phosphorylation	DGAALRLSSASPQET CCCCHHCCCCCCCCC	19.88	21743459
192	Phosphorylation	GAALRLSSASPQETI CCCHHCCCCCCCCCH	37.04	27180971
194	Phosphorylation	ALRLSSASPQETIIS CHHCCCCCCCCCHHH	29.12	22817900
198	Phosphorylation	SSASPQETIISDVLG CCCCCCCCHHHHHCC	20.54	29472430
201	Phosphorylation	SPQETIISDVLGKEE CCCCCHHHHHCCCCC	20.16	29472430
242	Phosphorylation	EYVERELSSRSLRNS HHHHHHHHHHHHHHH	20.96	22802335
249	Phosphorylation	SSRSLRNSLKRSVNE HHHHHHHHHHHHHHH	28.91	25338131
364	Phosphorylation	GPYAKLPSPEPSMSP CCCCCCCCCCCCCCC	52.94	22817900
368	Phosphorylation	KLPSPEPSMSPTMHR CCCCCCCCCCCCCCH	30.17	22817900
370	Phosphorylation	PSPEPSMSPTMHRRH CCCCCCCCCCCCHHH	22.89	26745281
372	Phosphorylation	PEPSMSPTMHRRHSR CCCCCCCCCCHHHCC	20.50	26745281
380	Phosphorylation	MHRRHSRSASACQIL CCHHHCCCCCHHHHH	29.59	25619855
382	Phosphorylation	RRHSRSASACQILIN HHHCCCCCHHHHHHC	30.72	25619855
398	Phosphorylation	PVNACELSPKGKEEA CCCCCCCCCCCCHHH	11.41	21082442
409	Phosphorylation	KEEAVDRTAPAAAET CHHHCCCCCCCHHHC	32.31	25619855
416	Phosphorylation	TAPAAAETTNESETV CCCCHHHCCCCCCCC	30.14	25619855
417	Phosphorylation	APAAAETTNESETVP CCCHHHCCCCCCCCC	28.61	25619855
420	Phosphorylation	AAETTNESETVPKSP HHHCCCCCCCCCCCC	40.41	25619855
422	Phosphorylation	ETTNESETVPKSPTD HCCCCCCCCCCCCCC	51.92	25619855
426	Phosphorylation	ESETVPKSPTDLTGV CCCCCCCCCCCCCCC	27.28	25619855
428	Phosphorylation	ETVPKSPTDLTGVCS CCCCCCCCCCCCCCC	51.21	25619855
431	Phosphorylation	PKSPTDLTGVCSSNV CCCCCCCCCCCCCCC	30.31	25619855
435	Phosphorylation	TDLTGVCSSNVSATK CCCCCCCCCCCCCCE	23.65	25619855
436	Phosphorylation	DLTGVCSSNVSATKI CCCCCCCCCCCCCEE	35.80	25619855
439	Phosphorylation	GVCSSNVSATKITSE CCCCCCCCCCEECCC	34.18	25619855
441	Phosphorylation	CSSNVSATKITSEST CCCCCCCCEECCCHH	18.57	25619855
550	Phosphorylation	SYDVKHPSPLLTQTQ CCCCCCCCCCCCCCC	28.09	-
579	Phosphorylation	NEQFVDNSFEKVKRR CHHHCCCCHHHHHHH	30.25	28066266
620	Phosphorylation	DRLLERRYPKGFVHI HHHHHHHCCCCEEEE	18.60	22817900
907	Phosphorylation	RVALSVATQKSLDRK HHHHHHHCCCCCCHH	34.08	-
914	Acetylation	TQKSLDRKKFMKVAE CCCCCCHHHHHHHHH	50.45	7613267
915	Acetylation	QKSLDRKKFMKVAEM CCCCCHHHHHHHHHC	52.14	7613277
1003	Phosphorylation	RKRPNVATI------ CCCCCCCCC------	23.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP110_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP110_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP110_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KI67_HUMAN	MKI67	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
MOONR_HUMAN	KIAA0753	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
CEP97_HUMAN	CEP97	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.