LYSC_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYSC_CHICK
• UniProt AC: P00698
• Protein Name: Lysozyme C
• Gene Name: LYZ
• Organism: Gallus gallus (Chicken).
• Sequence Length: 147
• Subcellular Localization: Secreted.
• Protein Description: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus..
• Protein Sequence: MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	LPLAALGKVFGRCEL HHHHHHHHHHHHHHH	34.93	15741597
19	Glycation	LPLAALGKVFGRCEL HHHHHHHHHHHHHHH	34.93	-
31	Acetylation	CELAAAMKRHGLDNY HHHHHHHHHCCCCCC	36.19	15741597
31	Glycation	CELAAAMKRHGLDNY HHHHHHHHHCCCCCC	36.19	-
38	Nitration	KRHGLDNYRGYSLGN HHCCCCCCCCCCCHH	12.70	-
41	Nitration	GLDNYRGYSLGNWVC CCCCCCCCCCHHHEE	7.54	-
42	Phosphorylation	LDNYRGYSLGNWVCA CCCCCCCCCHHHEEE	32.40	169238
51	Acetylation	GNWVCAAKFESNFNT HHHEEEEEEECCCCC	31.01	5421
51	Glycation	GNWVCAAKFESNFNT HHHEEEEEEECCCCC	31.01	-
68	Phosphorylation	TNRNTDGSTDYGILQ CCCCCCCCCCEEEEE	22.40	169238
71	Nitration	NTDGSTDYGILQINS CCCCCCCEEEEEECC	13.22	-
114	Glycation	TASVNCAKKIVSDGN HHHCHHHHHHHCCCC	45.28	-
114	Acetylation	TASVNCAKKIVSDGN HHHCHHHHHHHCCCC	45.28	15450814
115	Glycation	ASVNCAKKIVSDGNG HHCHHHHHHHCCCCC	29.80	-
115	Acetylation	ASVNCAKKIVSDGNG HHCHHHHHHHCCCCC	29.80	15450814
134	Acetylation	VAWRNRCKGTDVQAW HHHHHCCCCCCHHHH	62.70	15741597
134	Glycation	VAWRNRCKGTDVQAW HHHHHCCCCCCHHHH	62.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
42	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
42	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
68	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
68	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYSC_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYSC_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of LYSC_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.