LDHB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDHB_MOUSE
• UniProt AC: P16125
• Protein Name: L-lactate dehydrogenase B chain
• Gene Name: Ldhb
• Organism: Mus musculus (Mouse).
• Sequence Length: 334
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MATLKEKLIASVADDEAAVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATLKEKLI ------CCCHHHHHH	22.95	-
5	Acetylation	---MATLKEKLIASV ---CCCHHHHHHHHH	48.74	-
7	Ubiquitination	-MATLKEKLIASVAD -CCCHHHHHHHHHCC	43.54	22790023
7	Acetylation	-MATLKEKLIASVAD -CCCHHHHHHHHHCC	43.54	-
11	Phosphorylation	LKEKLIASVADDEAA HHHHHHHHHCCCCCC	15.73	25521595
36	S-nitrosylation	VGQVGMACAISILGK ECHHHHHHHHHHHCH	2.28	21278135
36	S-nitrosocysteine	VGQVGMACAISILGK ECHHHHHHHHHHHCH	2.28	-
44	Phosphorylation	AISILGKSLADELAL HHHHHCHHHHHHHHH	27.30	23737553
58	Ubiquitination	LVDVLEDKLKGEMMD HHHHHHHHHCCCCEE	42.60	22790023
58	Acetylation	LVDVLEDKLKGEMMD HHHHHHHHHCCCCEE	42.60	23236377
77	Ubiquitination	SLFLQTPKIVADKDY CEEECCCCEEECCCC	53.88	22790023
82	Ubiquitination	TPKIVADKDYSVTAN CCCEEECCCCEEECC	49.15	22790023
82	Acetylation	TPKIVADKDYSVTAN CCCEEECCCCEEECC	49.15	-
84	Phosphorylation	KIVADKDYSVTANSK CEEECCCCEEECCCE	15.69	25195567
85	Phosphorylation	IVADKDYSVTANSKI EEECCCCEEECCCEE	24.11	25521595
106	Phosphorylation	VRQQEGESRLNLVQR CCCCCCCHHHHHHHH	53.58	28464351
119	Ubiquitination	QRNVNVFKFIIPQIV HHHHCCHHHHHHHHH	31.22	22790023
119	Acetylation	QRNVNVFKFIIPQIV HHHHCCHHHHHHHHH	31.22	-
127	Acetylation	FIIPQIVKYSPDCTI HHHHHHHHCCCCCEE	41.46	-
128	Phosphorylation	IIPQIVKYSPDCTII HHHHHHHCCCCCEEE	17.97	23608596
129	Phosphorylation	IPQIVKYSPDCTIIV HHHHHHCCCCCEEEE	14.45	23608596
152	Phosphorylation	TYVTWKLSGLPKHRV HHHHHHHCCCCCCCE	34.26	28059163
164	S-nitrosylation	HRVIGSGCNLDSARF CCEECCCCCCCHHHH	4.97	21278135
164	S-nitrosocysteine	HRVIGSGCNLDSARF CCEECCCCCCCHHHH	4.97	-
168	Phosphorylation	GSGCNLDSARFRYLM CCCCCCCHHHHHHHH	25.22	28542873
233	Ubiquitination	ENWKEVHKMVVDSAY CCHHHHHHHHHHHHH	38.27	22790023
238	Phosphorylation	VHKMVVDSAYEVIKL HHHHHHHHHHHHHHC	22.57	20415495
240	Phosphorylation	KMVVDSAYEVIKLKG HHHHHHHHHHHHCCC	18.06	20415495
244	Ubiquitination	DSAYEVIKLKGYTNW HHHHHHHHCCCCCCC	49.69	22790023
294	S-nitrosylation	EVFLSLPCILNARGL CEEECCHHHHCCCCH	7.20	21278135
294	S-nitrosocysteine	EVFLSLPCILNARGL CEEECCHHHHCCCCH	7.20	-
308	Ubiquitination	LTSVINQKLKDDEVA HHHHHCHHCCCCHHH	53.68	22790023
310	Ubiquitination	SVINQKLKDDEVAQL HHHCHHCCCCHHHHH	70.89	22790023
319	Acetylation	DEVAQLRKSADTLWD CHHHHHHHHHHHHHH	59.60	-
319	Ubiquitination	DEVAQLRKSADTLWD CHHHHHHHHHHHHHH	59.60	22790023
329	Acetylation	DTLWDIQKDLKDL-- HHHHHHHHHHHCC--	66.42	-
329	Ubiquitination	DTLWDIQKDLKDL-- HHHHHHHHHHHCC--	66.42	22790023
332	Ubiquitination	WDIQKDLKDL----- HHHHHHHHCC-----	68.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LDHB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDHB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDHB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LDHB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-240, AND MASSSPECTROMETRY.
PubMed: 18034455