NSMA3_MOUSE - dbPTM
NSMA3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NSMA3_MOUSE
UniProt AC Q6ZPR5
Protein Name Sphingomyelin phosphodiesterase 4
Gene Name Smpd4
Organism Mus musculus (Mouse).
Sequence Length 823
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein. Golgi apparatus membrane
Single-pass membrane protein .
Protein Description Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. May sensitize cells to DNA damage-induced apoptosis..
Protein Sequence MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
130PhosphorylationQENVLPDSPLYHNKV
HCCCCCCCCCCCCCC		18.1826824392
133PhosphorylationVLPDSPLYHNKVQFP
CCCCCCCCCCCCCCC		13.5125159016
178UbiquitinationMSMTLHVRTSDCAYF
CEEEEEEECCCCCHH		20.1227667366
186UbiquitinationTSDCAYFTLVDRYLS
CCCCCHHEHHHHHHH		17.1327667366
221PhosphorylationSPSPAPRTPAMPFAS
CCCCCCCCCCCCCHH		17.8422006019
229PhosphorylationPAMPFASYGLHTSLL
CCCCCHHHCCCHHHH		21.9221183079
233PhosphorylationFASYGLHTSLLKRHI
CHHHCCCHHHHHHHH		26.5521183079
241PhosphorylationSLLKRHISHQTSVNA
HHHHHHHCCCCCCCC		11.9225159016
244PhosphorylationKRHISHQTSVNADPA
HHHHCCCCCCCCCCC		29.2625159016
245PhosphorylationRHISHQTSVNADPAS
HHHCCCCCCCCCCCC		13.5525159016
283PhosphorylationEMYQKMQSPHAKLEV
HHHHHHCCCCCCHHH		18.36-
330UbiquitinationEEHVLVVRLLLKHLH
HHHHHHHHHHHHHHH		16.4927667366
349PhosphorylationSLKPDQASPSAHSHA
CCCCCCCCCCCCCCC		17.4726060331
351PhosphorylationKPDQASPSAHSHATS
CCCCCCCCCCCCCCC		35.8026060331
384UbiquitinationYVFLQHCFGHWPLDA
HHHHHHHHCCCCCCH		8.2727667366
413UbiquitinationPWRYAPEKQAQGSDP
HHCCCCHHHCCCCCC		50.2922790023
414UbiquitinationWRYAPEKQAQGSDPQ
HCCCCHHHCCCCCCC		36.9427667366
418PhosphorylationPEKQAQGSDPQPRCV
CHHHCCCCCCCCCCC		33.7527841257
443UbiquitinationNLLMYTKLFVSFLNR
HHHHHHHHHHHHHHH		3.8527667366
458PhosphorylationALRTDLVSPKNALMV
HHCCCCCCHHHHHHH		37.1421659604
470MalonylationLMVFRVAKVFAQPNL
HHHHHHHHHHCCCCH		34.7232601280
535UbiquitinationVYSLEGQDCKYTPMF
EEEECCCCCCCCCCC		41.5527667366
536UbiquitinationYSLEGQDCKYTPMFG
EEECCCCCCCCCCCC		2.5227667366
549UbiquitinationFGPEIRTLVLRLAQL
CCHHHHHHHHHHHHH		2.1627667366
565UbiquitinationTQAKQTAKSISDQYV
HHHHHHHHHHHHHHC		52.2727667366
566UbiquitinationQAKQTAKSISDQYVE
HHHHHHHHHHHHHCC		25.5127667366
574PhosphorylationISDQYVESPTGRSFL
HHHHHCCCCCCCCHH		20.0928066266
576PhosphorylationDQYVESPTGRSFLSW
HHHCCCCCCCCHHHH		55.2828066266
595UbiquitinationLTDTNSCYPANDLDE
CCCCCCCCCCCCCHH		12.7527667366
649UbiquitinationSARDENGKQQLPDCI
CCCCCCCCCCCCCCE		46.59-
665PhosphorylationGEEGLILTPLGRYQI
CCCCEEEEECCCCEE		14.9622006019
749PhosphorylationLSNRHLLSPVGRRQV
HCCCCCCCCCCCCCC		24.7326824392
757PhosphorylationPVGRRQVTNPARGPR
CCCCCCCCCCCCCCC		27.4421454597
766PhosphorylationPARGPRLSLRFLGSY
CCCCCCCHHHHHHHH		20.8324704852
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NSMA3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NSMA3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NSMA3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NSMA3_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NSMA3_MOUSE

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Related Literatures of Post-Translational Modification

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