UniProt ID | SERA_MOUSE | |
---|---|---|
UniProt AC | Q61753 | |
Protein Name | D-3-phosphoglycerate dehydrogenase | |
Gene Name | Phgdh | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 533 | |
Subcellular Localization | ||
Protein Description | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.. | |
Protein Sequence | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWDRKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEAMGTLMHAWAGSPKGTIQVVTQGTSLKNAGTCLSPAVIVGLLREASKQADVNLVNAKLLVKEAGLNVTTSHNPGVPGEQGSGECLLTVALAGAPYQAVGLVQGTTPMLQMLNGAVFRPEVPLRRGQPLLVFRAQPSDPGMLPTMIGLLAEAGVQLLSYQTSMVSDGEPWHVMGLSSLLPSLETWKQHVLEAFQFCF | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MAFANLRKV ------CCCCCHHHH | 16.56 | - | |
8 | Succinylation | MAFANLRKVLISDSL CCCCCHHHHHHHCCC | 44.55 | 23806337 | |
8 | Acetylation | MAFANLRKVLISDSL CCCCCHHHHHHHCCC | 44.55 | 23806337 | |
12 | Phosphorylation | NLRKVLISDSLDPCC CHHHHHHHCCCCHHH | 19.58 | 23984901 | |
14 | Phosphorylation | RKVLISDSLDPCCRK HHHHHHCCCCHHHHH | 28.07 | 29233185 | |
18 | Glutathionylation | ISDSLDPCCRKILQD HHCCCCHHHHHHHHH | 3.32 | 24333276 | |
19 | S-nitrosylation | SDSLDPCCRKILQDG HCCCCHHHHHHHHHC | 6.37 | 24926564 | |
19 | Glutathionylation | SDSLDPCCRKILQDG HCCCCHHHHHHHHHC | 6.37 | 24333276 | |
21 | Ubiquitination | SLDPCCRKILQDGGL CCCHHHHHHHHHCCC | 33.58 | 22790023 | |
21 | Acetylation | SLDPCCRKILQDGGL CCCHHHHHHHHHCCC | 33.58 | 23806337 | |
33 | Acetylation | GGLQVVEKQNLSKEE CCCEEEEECCCCHHH | 32.64 | 23236377 | |
48 | Glutathionylation | LIAELQDCEGLIVRS HHHHHHCCCCEEECC | 2.63 | 24333276 | |
55 | Phosphorylation | CEGLIVRSATKVTAD CCCEEECCCCCCHHH | 29.42 | 27600695 | |
57 | Phosphorylation | GLIVRSATKVTADVI CEEECCCCCCHHHHH | 27.56 | 26745281 | |
58 | Acetylation | LIVRSATKVTADVIN EEECCCCCCHHHHHH | 36.99 | 23806337 | |
58 | Ubiquitination | LIVRSATKVTADVIN EEECCCCCCHHHHHH | 36.99 | 22790023 | |
60 | Phosphorylation | VRSATKVTADVINAA ECCCCCCHHHHHHHH | 20.78 | 21183079 | |
69 | Ubiquitination | DVINAAEKLQVVGRA HHHHHHHHHHEEECC | 39.22 | - | |
69 | Acetylation | DVINAAEKLQVVGRA HHHHHHHHHHEEECC | 39.22 | 23236377 | |
78 | Phosphorylation | QVVGRAGTGVDNVDL HEEECCCCCCCCCCH | 32.80 | 26824392 | |
234 | Glutathionylation | KGVRVVNCARGGIVD CCCEEEECCCCCCCC | 1.52 | 24333276 | |
254 | Glutathionylation | RALQSGQCAGAALDV HHHHCCCCCCEEEHC | 4.26 | 24333276 | |
281 | Glutathionylation | DHENVISCPHLGAST CCCCCCCCCCCCCCH | 1.37 | 24333276 | |
289 | Acetylation | PHLGASTKEAQSRCG CCCCCCHHHHHHHHC | 48.86 | 23236377 | |
289 | Ubiquitination | PHLGASTKEAQSRCG CCCCCCHHHHHHHHC | 48.86 | - | |
295 | Glutathionylation | TKEAQSRCGEEIAVQ HHHHHHHHCHHHHHH | 11.02 | 24333276 | |
322 | Phosphorylation | VVNAQALTSAFSPHT EEEHHHHHHCCCCCC | 22.48 | 26643407 | |
323 | Phosphorylation | VNAQALTSAFSPHTK EEHHHHHHCCCCCCC | 28.32 | 26643407 | |
326 | Phosphorylation | QALTSAFSPHTKPWI HHHHHCCCCCCCCCH | 18.58 | 26643407 | |
329 | Phosphorylation | TSAFSPHTKPWIGLA HHCCCCCCCCCHHHH | 42.03 | 26643407 | |
341 | Phosphorylation | GLAEAMGTLMHAWAG HHHHHHHHHHHHHCC | 14.07 | 26643407 | |
349 | Phosphorylation | LMHAWAGSPKGTIQV HHHHHCCCCCCEEEE | 18.72 | 26643407 | |
361 | Phosphorylation | IQVVTQGTSLKNAGT EEEEECCCCCCCCCC | 22.52 | 29514104 | |
362 | Phosphorylation | QVVTQGTSLKNAGTC EEEECCCCCCCCCCC | 44.14 | 29514104 | |
364 | Ubiquitination | VTQGTSLKNAGTCLS EECCCCCCCCCCCCC | 44.51 | - | |
368 | Phosphorylation | TSLKNAGTCLSPAVI CCCCCCCCCCCHHHH | 14.09 | 23984901 | |
369 | S-nitrosylation | SLKNAGTCLSPAVIV CCCCCCCCCCHHHHH | 3.28 | 19101475 | |
369 | S-nitrosocysteine | SLKNAGTCLSPAVIV CCCCCCCCCCHHHHH | 3.28 | - | |
369 | Glutathionylation | SLKNAGTCLSPAVIV CCCCCCCCCCHHHHH | 3.28 | 24333276 | |
371 | Phosphorylation | KNAGTCLSPAVIVGL CCCCCCCCHHHHHHH | 16.98 | 26745281 | |
383 | Phosphorylation | VGLLREASKQADVNL HHHHHHHHHHCCCCH | 22.13 | 23984901 | |
384 | Ubiquitination | GLLREASKQADVNLV HHHHHHHHHCCCCHH | 57.46 | 27667366 | |
394 | Succinylation | DVNLVNAKLLVKEAG CCCHHHHHHHHHHHC | 36.83 | 23806337 | |
394 | Acetylation | DVNLVNAKLLVKEAG CCCHHHHHHHHHHHC | 36.83 | 23806337 | |
394 | Ubiquitination | DVNLVNAKLLVKEAG CCCHHHHHHHHHHHC | 36.83 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SERA_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SERA_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SERA_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of SERA_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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