SERA_MOUSE - dbPTM
SERA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SERA_MOUSE
UniProt AC Q61753
Protein Name D-3-phosphoglycerate dehydrogenase
Gene Name Phgdh
Organism Mus musculus (Mouse).
Sequence Length 533
Subcellular Localization
Protein Description Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate..
Protein Sequence MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWDRKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEAMGTLMHAWAGSPKGTIQVVTQGTSLKNAGTCLSPAVIVGLLREASKQADVNLVNAKLLVKEAGLNVTTSHNPGVPGEQGSGECLLTVALAGAPYQAVGLVQGTTPMLQMLNGAVFRPEVPLRRGQPLLVFRAQPSDPGMLPTMIGLLAEAGVQLLSYQTSMVSDGEPWHVMGLSSLLPSLETWKQHVLEAFQFCF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAFANLRKV
------CCCCCHHHH		16.56-
8SuccinylationMAFANLRKVLISDSL
CCCCCHHHHHHHCCC		44.5523806337
8AcetylationMAFANLRKVLISDSL
CCCCCHHHHHHHCCC		44.5523806337
12PhosphorylationNLRKVLISDSLDPCC
CHHHHHHHCCCCHHH		19.5823984901
14PhosphorylationRKVLISDSLDPCCRK
HHHHHHCCCCHHHHH		28.0729233185
18GlutathionylationISDSLDPCCRKILQD
HHCCCCHHHHHHHHH		3.3224333276
19S-nitrosylationSDSLDPCCRKILQDG
HCCCCHHHHHHHHHC		6.3724926564
19GlutathionylationSDSLDPCCRKILQDG
HCCCCHHHHHHHHHC		6.3724333276
21UbiquitinationSLDPCCRKILQDGGL
CCCHHHHHHHHHCCC		33.5822790023
21AcetylationSLDPCCRKILQDGGL
CCCHHHHHHHHHCCC		33.5823806337
33AcetylationGGLQVVEKQNLSKEE
CCCEEEEECCCCHHH		32.6423236377
48GlutathionylationLIAELQDCEGLIVRS
HHHHHHCCCCEEECC		2.6324333276
55PhosphorylationCEGLIVRSATKVTAD
CCCEEECCCCCCHHH		29.4227600695
57PhosphorylationGLIVRSATKVTADVI
CEEECCCCCCHHHHH		27.5626745281
58AcetylationLIVRSATKVTADVIN
EEECCCCCCHHHHHH		36.9923806337
58UbiquitinationLIVRSATKVTADVIN
EEECCCCCCHHHHHH		36.9922790023
60PhosphorylationVRSATKVTADVINAA
ECCCCCCHHHHHHHH		20.7821183079
69UbiquitinationDVINAAEKLQVVGRA
HHHHHHHHHHEEECC		39.22-
69AcetylationDVINAAEKLQVVGRA
HHHHHHHHHHEEECC		39.2223236377
78PhosphorylationQVVGRAGTGVDNVDL
HEEECCCCCCCCCCH		32.8026824392
234GlutathionylationKGVRVVNCARGGIVD
CCCEEEECCCCCCCC		1.5224333276
254GlutathionylationRALQSGQCAGAALDV
HHHHCCCCCCEEEHC		4.2624333276
281GlutathionylationDHENVISCPHLGAST
CCCCCCCCCCCCCCH		1.3724333276
289AcetylationPHLGASTKEAQSRCG
CCCCCCHHHHHHHHC		48.8623236377
289UbiquitinationPHLGASTKEAQSRCG
CCCCCCHHHHHHHHC		48.86-
295GlutathionylationTKEAQSRCGEEIAVQ
HHHHHHHHCHHHHHH		11.0224333276
322PhosphorylationVVNAQALTSAFSPHT
EEEHHHHHHCCCCCC		22.4826643407
323PhosphorylationVNAQALTSAFSPHTK
EEHHHHHHCCCCCCC		28.3226643407
326PhosphorylationQALTSAFSPHTKPWI
HHHHHCCCCCCCCCH		18.5826643407
329PhosphorylationTSAFSPHTKPWIGLA
HHCCCCCCCCCHHHH		42.0326643407
341PhosphorylationGLAEAMGTLMHAWAG
HHHHHHHHHHHHHCC		14.0726643407
349PhosphorylationLMHAWAGSPKGTIQV
HHHHHCCCCCCEEEE		18.7226643407
361PhosphorylationIQVVTQGTSLKNAGT
EEEEECCCCCCCCCC		22.5229514104
362PhosphorylationQVVTQGTSLKNAGTC
EEEECCCCCCCCCCC		44.1429514104
364UbiquitinationVTQGTSLKNAGTCLS
EECCCCCCCCCCCCC		44.51-
368PhosphorylationTSLKNAGTCLSPAVI
CCCCCCCCCCCHHHH		14.0923984901
369S-nitrosylationSLKNAGTCLSPAVIV
CCCCCCCCCCHHHHH		3.2819101475
369S-nitrosocysteineSLKNAGTCLSPAVIV
CCCCCCCCCCHHHHH		3.28-
369GlutathionylationSLKNAGTCLSPAVIV
CCCCCCCCCCHHHHH		3.2824333276
371PhosphorylationKNAGTCLSPAVIVGL
CCCCCCCCHHHHHHH		16.9826745281
383PhosphorylationVGLLREASKQADVNL
HHHHHHHHHHCCCCH		22.1323984901
384UbiquitinationGLLREASKQADVNLV
HHHHHHHHHCCCCHH		57.4627667366
394SuccinylationDVNLVNAKLLVKEAG
CCCHHHHHHHHHHHC		36.8323806337
394AcetylationDVNLVNAKLLVKEAG
CCCHHHHHHHHHHHC		36.8323806337
394UbiquitinationDVNLVNAKLLVKEAG
CCCHHHHHHHHHHHC		36.83-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SERA_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SERA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SERA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SERA_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SERA_MOUSE

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Related Literatures of Post-Translational Modification

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