ACTBL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTBL_MOUSE
• UniProt AC: Q8BFZ3
• Protein Name: Beta-actin-like protein 2
• Gene Name: Actbl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
• Protein Sequence: MVDDELTALVVDNGSGMCKAGFGGDDAPRAVFPSMVGRPRHQGVMVGMGQKDCYVGDEAQSKRGILTLKYPIEHGVVTNWDDMEKIWYHTFYNELRVAPDEHPILLTEAPLNPKINREKMTQIMFEAFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYNFTTTAEREIVRDVKEKLCYVALDFEQEMVTAAASSSLERSYELPDGQVITIGNERFRCPEAIFQPSFLGIESRGIHETTFNSIMKCDVDIRKDLFANTVLSGGSTMYPGIADRMQKEIVTLAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPPIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVDDELTALVVDNG -CCCCCCEEEEEECC	18.85	25367039
15	Phosphorylation	ALVVDNGSGMCKAGF EEEEECCCCCCCCCC	29.61	-
34	Phosphorylation	APRAVFPSMVGRPRH CCCCCCHHHCCCCCC	18.03	37006769
45	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	23911929
48	Oxidation	HQGVMVGMGQKDCYV CCCEEEECCCCCEEC	3.32	23911929
51	Acetylation	VMVGMGQKDCYVGDE EEEECCCCCEECCCH	44.00	160849
54	Phosphorylation	GMGQKDCYVGDEAQS ECCCCCEECCCHHHC	20.01	28285833
61	Phosphorylation	YVGDEAQSKRGILTL ECCCHHHCCCCEEEE	31.22	25195567
62	Ubiquitination	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	27667366
67	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	22006019
70	Phosphorylation	RGILTLKYPIEHGVV CCEEEEECEECCCCC	16.74	7941953
78	Phosphorylation	PIEHGVVTNWDDMEK EECCCCCCCHHHHHH	28.34	51458113
92	Phosphorylation	KIWYHTFYNELRVAP HHHHHHHHCCEECCC	14.64	51458105
142	Phosphorylation	VAIQAVLSLYASGRT HHHHHHHHHHHCCCC	16.85	21082442
144	Phosphorylation	IQAVLSLYASGRTTG HHHHHHHHHCCCCEE	8.71	30803941
146	Phosphorylation	AVLSLYASGRTTGIV HHHHHHHCCCCEEEE	18.43	-
149	Phosphorylation	SLYASGRTTGIVMDS HHHHCCCCEEEEEEC	32.66	19060867
150	Phosphorylation	LYASGRTTGIVMDSG HHHCCCCEEEEEECC	24.45	23984901
156	Phosphorylation	TTGIVMDSGDGVTHT CEEEEEECCCCCEEE	22.23	23984901
161	Phosphorylation	MDSGDGVTHTVPIYE EECCCCCEEEEEEEC	19.84	21183079
163	Phosphorylation	SGDGVTHTVPIYEGY CCCCCEEEEEEECCC	20.72	21183079
167	Phosphorylation	VTHTVPIYEGYALPH CEEEEEEECCCCCCH	9.38	20438120
170	Phosphorylation	TVPIYEGYALPHAIL EEEEECCCCCCHHHH	7.94	40701
187	Phosphorylation	DLAGRDLTDYLMKIL HHCCCCHHHHHHHHH	27.21	24899341
189	Phosphorylation	AGRDLTDYLMKILTE CCCCHHHHHHHHHHH	11.94	2001175
192	Ubiquitination	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	-
192	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	22646693
234	Phosphorylation	EMVTAAASSSLERSY HHHHHHHHCCCCCEE	18.74	41301469
235	Phosphorylation	MVTAAASSSLERSYE HHHHHHHCCCCCEEE	33.93	41301475
236	Phosphorylation	VTAAASSSLERSYEL HHHHHHCCCCCEEEC	31.58	41301481
240	Phosphorylation	ASSSLERSYELPDGQ HHCCCCCEEECCCCC	17.37	24925903
240	O-linked_Glycosylation	ASSSLERSYELPDGQ HHCCCCCEEECCCCC	17.37	6479277
241	Phosphorylation	SSSLERSYELPDGQV HCCCCCEEECCCCCE	27.92	24925903
250	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	46158343
327	Ubiquitination	TLAPSTMKIKIIAPP EECCCCCEEEEECCC	40.72	27667366
329	Ubiquitination	APSTMKIKIIAPPER CCCCCEEEEECCCCC	23.65	22790023
329	Acetylation	APSTMKIKIIAPPER CCCCCEEEEECCCCC	23.65	7629229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTBL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
45	M	Oxidation	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	23911929
48	M	Oxidation	Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.	23911929
85	K	Methylation	Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTBL_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTBL_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.