SYMC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYMC_MOUSE
• UniProt AC: Q68FL6
• Protein Name: Methionine--tRNA ligase, cytoplasmic
• Gene Name: Mars
• Organism: Mus musculus (Mouse).
• Sequence Length: 902
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA..
• Protein Sequence: MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALHCLVVQGKKGEDILGPLRRVLTHIDHSLSRQNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQQGVLALRLYLQKQPQPQPPPPEGRTVSNELEEEELATLSEEDIVTAVAAWEKGLESLPPLKLQQHPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYCRLRQWNTLYLCGTDEYGTATETKAMEEGLTPREICDKYHAIHADIYRWFGISFDTFGRTTTPQQTKITQDIFQRLLTRGFVLRDTVEQLRCERCARFLADRFVEGVCPFCGYEEARGDQCDRCGKLINAIELKKPQCKICRSCPVVRSSQHLFLDLPKLEKRLEDWLGKTVPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYVSITANYTDQWEKWWKNPEQVDLYQFMAKDNVPFHGLVFPCSVLGAEDNYTLVKHIIATEYLNYEDGKFSKSRGIGVFGDMAKDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMALTPDDRRLVAHVSWELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGGEMDRQRAGTVTGMAVNMAALLSVMLQPYMPTVSSTIQTQLQLPPAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQAKGSPKPAAVEAVTAAGSQHIQTLTDEVTKQGNVVRELKAQKADKNQVAAEVAKLLDLKKQLALAEGKPIETPKGKKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Glutathionylation	STVGPEECVVPFLTR EECCHHHHEEECCCC	3.40	24333276
191	Ubiquitination	RAAETVLKQQGVLAL HHHHHHHHHHCHHHH	35.92	-
253	Ubiquitination	LESLPPLKLQQHPVL HHHCCCCCCCCCCCC	50.45	-
335	Glutathionylation	GLTPREICDKYHAIH CCCHHHHHHHHCHHH	2.94	24333276
337	Ubiquitination	TPREICDKYHAIHAD CHHHHHHHHCHHHHH	34.23	-
359	Phosphorylation	SFDTFGRTTTPQQTK CCCCCCCCCCCCHHH	35.09	29895711
360	Phosphorylation	FDTFGRTTTPQQTKI CCCCCCCCCCCHHHH	34.81	29895711
361	Phosphorylation	DTFGRTTTPQQTKIT CCCCCCCCCCHHHHH	20.63	29895711
365	Phosphorylation	RTTTPQQTKITQDIF CCCCCCHHHHHHHHH	21.11	29895711
366	Ubiquitination	TTTPQQTKITQDIFQ CCCCCHHHHHHHHHH	39.14	-
368	Phosphorylation	TPQQTKITQDIFQRL CCCHHHHHHHHHHHH	23.03	29895711
377	Phosphorylation	DIFQRLLTRGFVLRD HHHHHHHHCCCCCHH	33.08	29895711
449	Phosphorylation	SCPVVRSSQHLFLDL CCCCEECCCEEEECH	15.85	24899341
502	Ubiquitination	RCITRDLKWGTPVPL CEEECCCCCCCCCCC	48.11	-
568	Glutathionylation	FHGLVFPCSVLGAED CCCEEEEHHHCCCCC	2.74	24333276
588	Phosphorylation	KHIIATEYLNYEDGK HHHHHHCCCCCCCCC	8.90	-
591	Phosphorylation	IATEYLNYEDGKFSK HHHCCCCCCCCCCCC	16.89	25367039
595	Ubiquitination	YLNYEDGKFSKSRGI CCCCCCCCCCCCCCE	59.80	-
597	Phosphorylation	NYEDGKFSKSRGIGV CCCCCCCCCCCCEEE	32.96	25367039
598	Ubiquitination	YEDGKFSKSRGIGVF CCCCCCCCCCCEEEE	47.51	-
599	Phosphorylation	EDGKFSKSRGIGVFG CCCCCCCCCCEEEEH	34.24	25367039
700	Ubiquitination	HYHQLLEKVRIRDAL HHHHHHHHHHHHHHH	36.46	-
728	Acetylation	IQVNEPWKRIKGGEM EEECCCHHHCCCCCC	55.77	23236377
728	Malonylation	IQVNEPWKRIKGGEM EEECCCHHHCCCCCC	55.77	26320211
731	Malonylation	NEPWKRIKGGEMDRQ CCCHHHCCCCCCCHH	65.97	26320211
789	S-nitrosylation	ILATSFICTLPAGHR HHHHEEECCCCCCCC	2.77	22178444
789	S-palmitoylation	ILATSFICTLPAGHR HHHHEEECCCCCCCC	2.77	28526873
806	Ubiquitination	TVSPLFQKLENDQIE CCCHHHHHHCHHHHH	50.89	-
827	Phosphorylation	GGGQAKGSPKPAAVE CCCCCCCCCCCHHHH	29.10	25521595
837	Phosphorylation	PAAVEAVTAAGSQHI CHHHHHHHHCCCHHH	20.17	25293948
841	Phosphorylation	EAVTAAGSQHIQTLT HHHHHCCCHHHHHHH	17.54	25619855
846	Phosphorylation	AGSQHIQTLTDEVTK CCCHHHHHHHHHHHH	30.90	25619855
848	Phosphorylation	SQHIQTLTDEVTKQG CHHHHHHHHHHHHHC	33.24	25619855
852	Phosphorylation	QTLTDEVTKQGNVVR HHHHHHHHHHCHHHH	18.66	25619855
868	Malonylation	LKAQKADKNQVAAEV HHHHCCCHHHHHHHH	54.89	26320211
895	Phosphorylation	AEGKPIETPKGKKKK HCCCCCCCCCCCCCC	30.90	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYMC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYMC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYMC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYMC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.