PLST_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLST_MOUSE
• UniProt AC: Q99K51
• Protein Name: Plastin-3
• Gene Name: Pls3
• Organism: Mus musculus (Mouse).
• Sequence Length: 630
• Subcellular Localization: Cytoplasm.
• Protein Description: Actin-bundling protein..
• Protein Sequence: MDEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMVDGDRNKDGKISFNEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERAINKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKNPAKFSLVGIGGQDLNDGNPTLTLAVVWQLMRRYTLNVLEDLGEGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EMATTQISKDELDEL HHHHCCCCHHHHHHH	25.00	-
18	Ubiquitination	KDELDELKEAFAKVD HHHHHHHHHHHHCCC	44.97	-
33	S-palmitoylation	LNSNGFICDYELHEL CCCCCEECCHHHHHH	4.21	28680068
33	S-nitrosylation	LNSNGFICDYELHEL CCCCCEECCHHHHHH	4.21	22178444
33	Glutathionylation	LNSNGFICDYELHEL CCCCCEECCHHHHHH	4.21	24333276
59	Acetylation	KVREIIQKLMVDGDR HHHHHHHHHCCCCCC	28.30	22826441
91	Acetylation	VKSSDIAKTFRKAIN HCCCHHHHHHHHHHH	48.83	22826441
100	Malonylation	FRKAINRKEGICALG HHHHHHHCCCEEECC	56.66	26320211
113	Phosphorylation	LGGTSELSSEGTQHS CCCCCCCCCCCCCCC	23.45	28973931
127	Phosphorylation	SYSEEEKYAFVNWIN CCCHHHHHHHHHHHH	14.46	27180971
143	S-nitrosylation	ALENDPDCRHVIPMN HHHCCCCCCCCCCCC	3.84	24926564
266	Ubiquitination	ETLEELMKLSPEELL CHHHHHHCCCHHHHH	59.44	-
268	Phosphorylation	LEELMKLSPEELLLR HHHHHCCCHHHHHHH	25.42	27180971
293	Phosphorylation	WQKINNFSADIKDSK CHHCCCCCCCCCCCH	27.44	25521595
297	Acetylation	NNFSADIKDSKAYFH CCCCCCCCCCHHHHH	57.40	23236377
300	Acetylation	SADIKDSKAYFHLLN CCCCCCCHHHHHHHH	58.18	-
326	Phosphorylation	PRIDINMSGFNETDD CCCEECCCCCCCHHH	35.43	29514104
331	Phosphorylation	NMSGFNETDDLKRAE CCCCCCCHHHHHHHH	35.60	29472430
335	Acetylation	FNETDDLKRAESMLQ CCCHHHHHHHHHHHH	57.46	23954790
335	Ubiquitination	FNETDDLKRAESMLQ CCCHHHHHHHHHHHH	57.46	-
339	Phosphorylation	DDLKRAESMLQQADK HHHHHHHHHHHHHHH	24.65	25521595
346	Acetylation	SMLQQADKLGCRQFV HHHHHHHHHCCCCCC	50.20	22826441
346	Ubiquitination	SMLQQADKLGCRQFV HHHHHHHHHCCCCCC	50.20	-
349	Glutathionylation	QQADKLGCRQFVTPA HHHHHHCCCCCCCHH	4.47	24333276
354	Phosphorylation	LGCRQFVTPADVVSG HCCCCCCCHHHHHCC	17.66	-
360	Phosphorylation	VTPADVVSGNPKLNL CCHHHHHCCCCCCHH	32.47	28059163
364	Acetylation	DVVSGNPKLNLAFVA HHHCCCCCCHHHHHH	54.74	-
391	Phosphorylation	ENQDIDWTLLEGETR CCCCCCCEEECCCCH	20.09	-
409	Phosphorylation	TFRNWMNSLGVNPHV HHHHHHHHCCCCCCH	15.47	-
437	Ubiquitination	LQLYERIKVPVDWSK HHHHHHCCCCCCHHH	46.86	-
459	Acetylation	KLGANMKKLENCNYA CCCCCHHHHHCCCCC	50.71	22826441
459	Ubiquitination	KLGANMKKLENCNYA CCCCCHHHHHCCCCC	50.71	-
471	Malonylation	NYAVELGKNPAKFSL CCCHHCCCCCCCEEE	72.83	26320211
475	Acetylation	ELGKNPAKFSLVGIG HCCCCCCCEEEEEEC	36.42	-
477	Phosphorylation	GKNPAKFSLVGIGGQ CCCCCCEEEEEECCC	22.80	-
537	Ubiquitination	RTLSEAGKSTSIQSF HHHHHCCCCCCHHHH	58.57	-
538	Phosphorylation	TLSEAGKSTSIQSFK HHHHCCCCCCHHHHC	26.86	29472430
539	Phosphorylation	LSEAGKSTSIQSFKD HHHCCCCCCHHHHCC	33.08	29472430
540	Phosphorylation	SEAGKSTSIQSFKDK HHCCCCCCHHHHCCC	26.22	29899451
545	Acetylation	STSIQSFKDKTISSS CCCHHHHCCCCCCHH	64.66	23954790
545	Malonylation	STSIQSFKDKTISSS CCCHHHHCCCCCCHH	64.66	26320211
545	Succinylation	STSIQSFKDKTISSS CCCHHHHCCCCCCHH	64.66	23954790
547	Malonylation	SIQSFKDKTISSSLA CHHHHCCCCCCHHHH	48.63	26073543
566	Glutathionylation	IDAIQPGCINYDLVK HHHHCCCCCCCCHHH	2.01	24333276
582	Acetylation	GNLTEDDKHNNAKYA CCCCCCCCCCCHHHH	61.63	23201123
587	Acetylation	DDKHNNAKYAVSMAR CCCCCCHHHHHHHHH	35.55	23954790
611	Ubiquitination	PEDLVEVKPKMVMTV CHHHCCCCHHHHHHH	25.97	-
611	Acetylation	PEDLVEVKPKMVMTV CHHHCCCCHHHHHHH	25.97	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLST_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLST_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLST_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATX2_MOUSE	Atxn2	physical	16115810

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.