SLTM_MOUSE - dbPTM
SLTM_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLTM_MOUSE
UniProt AC Q8CH25
Protein Name SAFB-like transcription modulator
Gene Name Sltm
Organism Mus musculus (Mouse).
Sequence Length 1031
Subcellular Localization Nucleus . Detected in punctate structures.
Protein Description When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis..
Protein Sequence MAAAAGAVVASAASGPAEGKKITELRVIDLRSELKRRNLDINGVKTVLVSRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKQEADELSGDASVEDDSFVKDCELENQETHDQDGNEELKDLEEFGENEEEIVHSQELLSTEENKTTQEFVEAEAIEDREKEDIESQETEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEANATGKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDVQDAIAQSPEKEAKDYEMNPNHKDGKKEDSVKGEPVEKEARESAKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTGSAGGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCVAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSAGDKKNASDRSAKTQASIKKEEKRSSEKSEKKESKDTKKIEKDEKNDDGPSGQTSESLKKSEEKKRISSKSPGHMVILNQTKGDHCRPSRRGRYEKGHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLKQAVEFRRRKEIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRREAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTEARFGHGSDYRQQSRFLDFSHRERARFPDTASVQSSFERRERFVGQSEGKKPRPAARREEPSFERYPKNFSDSRRNEPPPPRNELRETDRREVRGERDERRTVILHDRPEVAHPRHPRETVPNPSRPTSWKSEANMSTEKRESRVERPERSGREVSGHTVRGAPPGNRSSASGYGTREGERGVIADRGSGTQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSTASPVNRIVQMSGNSLPRGSSSGFKPFKSGPPRRF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAAAGAVV
------CCHHHHHHH		19.67-
11PhosphorylationAAGAVVASAASGPAE
HHHHHHHHHCCCCCC		16.8630482847
14PhosphorylationAVVASAASGPAEGKK
HHHHHHCCCCCCCCC		45.0529514104
23PhosphorylationPAEGKKITELRVIDL
CCCCCCCCEEEEEEH		37.5320469934
46PhosphorylationLDINGVKTVLVSRLK
CCCCCHHHHHHHHHH		19.3722942356
50PhosphorylationGVKTVLVSRLKQAIE
CHHHHHHHHHHHHHH		27.9522942356
69PhosphorylationDPDNIELTVSTDTPN
CCCCEEEEEECCCCC		10.3026745281
71PhosphorylationDNIELTVSTDTPNKK
CCEEEEEECCCCCCC		18.4826745281
72PhosphorylationNIELTVSTDTPNKKP
CEEEEEECCCCCCCC		39.2926745281
74PhosphorylationELTVSTDTPNKKPTK
EEEEECCCCCCCCCC		28.9326745281
80PhosphorylationDTPNKKPTKGKGKKQ
CCCCCCCCCCCCCHH		62.4026745281
93PhosphorylationKQEADELSGDASVED
HHCHHHHCCCCCCCC		32.3625521595
97PhosphorylationDELSGDASVEDDSFV
HHHCCCCCCCCCCCE		30.6825521595
102PhosphorylationDASVEDDSFVKDCEL
CCCCCCCCCEEEEEC		44.2425619855
139PhosphorylationNEEEIVHSQELLSTE
CHHHHHHHHHHHCCC		17.9217525332
144PhosphorylationVHSQELLSTEENKTT
HHHHHHHCCCCCCCH		46.5325293948
145PhosphorylationHSQELLSTEENKTTQ
HHHHHHCCCCCCCHH		47.4925293948
170PhosphorylationREKEDIESQETEAQE
HHHHHHHHHHHHHHC		33.3821149613
173PhosphorylationEDIESQETEAQEGED
HHHHHHHHHHHCCCC		29.0521149613
182PhosphorylationAQEGEDDTFLTAQDG
HHCCCCCCEEECCCC		32.6321149613
185PhosphorylationGEDDTFLTAQDGEEE
CCCCCEEECCCCCCH		20.3421149613
199 (in isoform 2)Phosphorylation-19.0725521595
201PhosphorylationNEKDIAGSGDGTQEV
CCCCCCCCCCCCCEE		25.3723375375
205PhosphorylationIAGSGDGTQEVSKPL
CCCCCCCCCEECCCC		26.7127841257
206 (in isoform 2)Phosphorylation-55.4125521595
217PhosphorylationKPLPSEGSLAEADHT
CCCCCCCCCCCCCCH		21.9824899341
224PhosphorylationSLAEADHTAHEEMEA
CCCCCCCHHHHHHHH		30.2024899341
289PhosphorylationVQDAIAQSPEKEAKD
HHHHHHCCHHHHHHH		26.4624925903
297PhosphorylationPEKEAKDYEMNPNHK
HHHHHHHCCCCCCCC		19.1725159016
311PhosphorylationKDGKKEDSVKGEPVE
CCCCCCCCCCCCCCH		27.1626824392
330PhosphorylationESAKKAESGDKEKDT
HHHHHHHCCCCHHCC		58.09-
343PhosphorylationDTLKKGPSSTGASGQ
CCCCCCCCCCCCCCC		49.5623684622
344PhosphorylationTLKKGPSSTGASGQA
CCCCCCCCCCCCCCC		33.7126824392
345PhosphorylationLKKGPSSTGASGQAK
CCCCCCCCCCCCCCC		40.9022817900
348PhosphorylationGPSSTGASGQAKSSS
CCCCCCCCCCCCCCC		32.5529550500
353PhosphorylationGASGQAKSSSKESKD
CCCCCCCCCCCCCCC		42.7425619855
354PhosphorylationASGQAKSSSKESKDS
CCCCCCCCCCCCCCC		44.7325619855
355PhosphorylationSGQAKSSSKESKDSK
CCCCCCCCCCCCCCC		47.7525619855
358PhosphorylationAKSSSKESKDSKTSS
CCCCCCCCCCCCCCC		45.5620139300
364PhosphorylationESKDSKTSSKDDKGS
CCCCCCCCCCCCCCC		38.8420139300
371PhosphorylationSSKDDKGSTGSAGGS
CCCCCCCCCCCCCCC		35.0227087446
372PhosphorylationSKDDKGSTGSAGGSS
CCCCCCCCCCCCCCC		43.7727087446
374PhosphorylationDDKGSTGSAGGSSGS
CCCCCCCCCCCCCCC		24.6723684622
393PhosphorylationIWVSGLSSNTKAADL
EEEECCCCCCCHHHH		54.2722871156
401AcetylationNTKAADLKNLFGKYG
CCCHHHHHHHHHHHC		52.75-
417PhosphorylationVLSAKVVTNARSPGA
EEEEEEEECCCCCCC		26.5829472430
421PhosphorylationKVVTNARSPGAKCYG
EEEECCCCCCCEEEE		25.8527087446
494MalonylationNASDRSAKTQASIKK
CHHHHHHHHHHHHHH		42.2826320211
532PhosphorylationEKNDDGPSGQTSESL
CCCCCCCCCCCHHHH		49.4123984901
535PhosphorylationDDGPSGQTSESLKKS
CCCCCCCCHHHHHHH		37.6825159016
536PhosphorylationDGPSGQTSESLKKSE
CCCCCCCHHHHHHHH		19.8025159016
538PhosphorylationPSGQTSESLKKSEEK
CCCCCHHHHHHHHHH		45.3025159016
542PhosphorylationTSESLKKSEEKKRIS
CHHHHHHHHHHHCCC		49.7726824392
549PhosphorylationSEEKKRISSKSPGHM
HHHHHCCCCCCCCCE		35.4322942356
550PhosphorylationEEKKRISSKSPGHMV
HHHHCCCCCCCCCEE		34.4827087446
552PhosphorylationKKRISSKSPGHMVIL
HHCCCCCCCCCEEEE		37.7527087446
562PhosphorylationHMVILNQTKGDHCRP
CEEEECCCCCCCCCC		35.6028833060
589PhosphorylationSKEKERASLDKKRDK
CHHHHHHHCHHHCCH		43.2426824392
625UbiquitinationLVRFERLKQAVEFRR
HHHHHHHHHHHHHHH		42.29-
747PhosphorylationWSENKKLSLDTEARF
CCCCCCCCCCCHHHC		32.8325266776
750PhosphorylationNKKLSLDTEARFGHG
CCCCCCCCHHHCCCC		36.5228066266
758PhosphorylationEARFGHGSDYRQQSR
HHHCCCCCCHHHHHH		26.2928066266
780PhosphorylationERARFPDTASVQSSF
HHHCCCCCHHHHCHH		22.5228066266
782PhosphorylationARFPDTASVQSSFER
HCCCCCHHHHCHHHH		23.8425619855
785PhosphorylationPDTASVQSSFERRER
CCCHHHHCHHHHHHH		34.5325619855
786PhosphorylationDTASVQSSFERRERF
CCHHHHCHHHHHHHH		17.6525619855
797PhosphorylationRERFVGQSEGKKPRP
HHHHCCCCCCCCCCC		42.2528066266
812PhosphorylationAARREEPSFERYPKN
CHHCCCCCHHHCCCC		42.9126824392
816PhosphorylationEEPSFERYPKNFSDS
CCCCHHHCCCCCCCC		16.0320531401
821PhosphorylationERYPKNFSDSRRNEP
HHCCCCCCCCCCCCC		44.0320531401
823PhosphorylationYPKNFSDSRRNEPPP
CCCCCCCCCCCCCCC		31.7620531401
875PhosphorylationRETVPNPSRPTSWKS
CCCCCCCCCCCCCCC		58.4928066266
878PhosphorylationVPNPSRPTSWKSEAN
CCCCCCCCCCCCCCC		46.2228066266
879PhosphorylationPNPSRPTSWKSEANM
CCCCCCCCCCCCCCC		34.8828066266
887PhosphorylationWKSEANMSTEKRESR
CCCCCCCCHHHHHHH		32.9727841257
906PhosphorylationERSGREVSGHTVRGA
CCCCCCCCCCCCCCC		21.8025266776
919PhosphorylationGAPPGNRSSASGYGT
CCCCCCCCCCCCCCC		33.9729899451
920PhosphorylationAPPGNRSSASGYGTR
CCCCCCCCCCCCCCC		24.1827149854
922PhosphorylationPGNRSSASGYGTREG
CCCCCCCCCCCCCCC		34.2030635358
924PhosphorylationNRSSASGYGTREGER
CCCCCCCCCCCCCCC		16.9030635358
926PhosphorylationSSASGYGTREGERGV
CCCCCCCCCCCCCEE		19.6430635358
939PhosphorylationGVIADRGSGTQHYPE
EEEECCCCCCCCCCH		39.2926824392
941PhosphorylationIADRGSGTQHYPEER
EECCCCCCCCCCHHH		17.5526643407
944PhosphorylationRGSGTQHYPEERHVV
CCCCCCCCCHHHCCH		11.5226643407
992PhosphorylationRAGAGMITQHSSTAS
CCCCCCCCCCCCCCC		16.0126060331
995PhosphorylationAGMITQHSSTASPVN
CCCCCCCCCCCCCCH		21.4023684622
996PhosphorylationGMITQHSSTASPVNR
CCCCCCCCCCCCCHH		26.3523684622
997PhosphorylationMITQHSSTASPVNRI
CCCCCCCCCCCCHHE		33.8823684622
999PhosphorylationTQHSSTASPVNRIVQ
CCCCCCCCCCHHEEE		29.4827087446
1008PhosphorylationVNRIVQMSGNSLPRG
CHHEEECCCCCCCCC		20.1026745281
1011PhosphorylationIVQMSGNSLPRGSSS
EEECCCCCCCCCCCC		43.1926824392
1014MethylationMSGNSLPRGSSSGFK
CCCCCCCCCCCCCCC		64.0224129315
1016PhosphorylationGNSLPRGSSSGFKPF
CCCCCCCCCCCCCCC		23.7025266776
1017PhosphorylationNSLPRGSSSGFKPFK
CCCCCCCCCCCCCCC		36.9926824392
1018PhosphorylationSLPRGSSSGFKPFKS
CCCCCCCCCCCCCCC		50.3626745281
1021AcetylationRGSSSGFKPFKSGPP
CCCCCCCCCCCCCCC		53.7423806337
1025PhosphorylationSGFKPFKSGPPRRF-
CCCCCCCCCCCCCC-		57.8425890499
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLTM_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLTM_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLTM_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SLTM_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLTM_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-999, AND MASSSPECTROMETRY.
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-552, ANDMASS SPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-552, ANDMASS SPECTROMETRY.
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139, AND MASSSPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASSSPECTROMETRY.
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line.";
Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.;
Mol. Cell. Proteomics 3:279-286(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.

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