RB3GP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB3GP_MOUSE
• UniProt AC: Q80UJ7
• Protein Name: Rab3 GTPase-activating protein catalytic subunit
• Gene Name: Rab3gap1
• Organism: Mus musculus (Mouse).
• Sequence Length: 981
• Subcellular Localization: Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction..
• Protein Description: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)..
• Protein Sequence: MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGPSLGKPLEKGIFTSGTWEERSDEISFADFRFSVTHHYLVQESPDKERKDEELEDAIPQSMQDLLCMNNDFPPRAHCLVRWYGLREFVVIAPAAHSDAVLSESKCNLLLSSISIALGNTGCQVPLFVQIHHKWRRMYMGECQGPGVRTDFEMVHLRKVPSQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRLTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPVQAPHWSVRVRKADNPQCLLGDFVTEFLKICRRKESTDEILGRSTFEEEGREVADITHALSKLTEPAPVPIHKLSVSNMVHTAKKKIRKHRGEESPLNSDVLNTILLFLFPDAVSEKPLDGTTSIDNSIPAPEAGDYTLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGSPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSLSDSTTSAYPGDAGKTGGQLGLDHLRDTEKEKGEVGKSWDSWSDSEEEFFECLSDTEDLKGNGQESGKKGGPKEMANLKPEGRLHQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCFLEDFVRWYSPRDYIEEEVTDEKGNVVLKGELSARMKIPSNMWVEAWETAKPVPARRQRRLFDDTREAEKVLHYLAMQKPADLARHLLPCVIHAAVLKVKEEESLENIPSVKKIIKQIIAHSSKVLHFPNPEDKKLEEIILQITTVEAIIARARSLKAKFGTEKCEHEEEKEGLERFVSCLLEQPEVSVTGAGRGHAGRIIHKLFVNAQRAAAVALPEEELKKSGCPEERRQTLVSDFPPPAGRELILRATVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAADSEPESEVF ---CCCCCCCHHHEE	50.77	27180971
9	Phosphorylation	AADSEPESEVFEITD CCCCCCHHHEEEECC	50.18	21743459
15	Phosphorylation	ESEVFEITDFTTASE HHHEEEECCCCCHHH	20.19	25293948
18	Phosphorylation	VFEITDFTTASEWER EEEECCCCCHHHHHH	25.02	20415495
19	Phosphorylation	FEITDFTTASEWERF EEECCCCCHHHHHHH	28.34	20415495
21	Phosphorylation	ITDFTTASEWERFIS ECCCCCHHHHHHHHH	40.94	20415495
28	Phosphorylation	SEWERFISKVEEVLN HHHHHHHHHHHHHHC	28.12	25619855
38	Ubiquitination	EEVLNDWKLIGPSLG HHHHCCCCCCCCCCC	32.84	-
43	Phosphorylation	DWKLIGPSLGKPLEK CCCCCCCCCCCCCCC	44.53	25619855
83	Phosphorylation	HHYLVQESPDKERKD EEEECCCCCCHHHCH	22.70	25521595
181	S-nitrosocysteine	RRMYMGECQGPGVRT HHHHCCCCCCCCCCC	4.73	-
181	S-nitrosylation	RRMYMGECQGPGVRT HHHHCCCCCCCCCCC	4.73	21278135
322	S-nitrosocysteine	RKADNPQCLLGDFVT ECCCCCCCCHHHHHH	3.41	-
322	S-nitrosylation	RKADNPQCLLGDFVT ECCCCCCCCHHHHHH	3.41	22178444
340	Phosphorylation	KICRRKESTDEILGR HHHCCCCCCCHHHCC	44.16	29899451
379	Phosphorylation	PVPIHKLSVSNMVHT CCCCHHCCHHHHHHH	28.44	25266776
381	Phosphorylation	PIHKLSVSNMVHTAK CCHHCCHHHHHHHHH	18.81	24719451
535	Phosphorylation	ARDEGKKTSLSDSTT HHHCCCCCCCCCCCC	38.08	25521595
536	Phosphorylation	RDEGKKTSLSDSTTS HHCCCCCCCCCCCCC	34.45	25521595
538	Phosphorylation	EGKKTSLSDSTTSAY CCCCCCCCCCCCCCC	29.31	27087446
540	Phosphorylation	KKTSLSDSTTSAYPG CCCCCCCCCCCCCCC	30.15	25619855
541	Phosphorylation	KTSLSDSTTSAYPGD CCCCCCCCCCCCCCC	29.75	25619855
542	Phosphorylation	TSLSDSTTSAYPGDA CCCCCCCCCCCCCCC	18.47	25619855
543	Phosphorylation	SLSDSTTSAYPGDAG CCCCCCCCCCCCCCC	26.37	25619855
545	Phosphorylation	SDSTTSAYPGDAGKT CCCCCCCCCCCCCCC	13.91	25619855
574	Phosphorylation	EKGEVGKSWDSWSDS HCCCCCCCCCCCCCC	30.13	22817900
577	Phosphorylation	EVGKSWDSWSDSEEE CCCCCCCCCCCCHHH	23.40	29550500
579	Phosphorylation	GKSWDSWSDSEEEFF CCCCCCCCCCHHHHH	34.90	22817900
581	Phosphorylation	SWDSWSDSEEEFFEC CCCCCCCCHHHHHHH	41.20	22817900
590	Phosphorylation	EEFFECLSDTEDLKG HHHHHHHHCCCCCCC	54.89	29550500
592	Phosphorylation	FFECLSDTEDLKGNG HHHHHHCCCCCCCCC	28.20	29550500
663	Phosphorylation	EVLAKLGTSAEGAHL HHHHHHCCCCHHHHH	34.89	30635358
664	Phosphorylation	VLAKLGTSAEGAHLR HHHHHCCCCHHHHHH	23.64	30635358
673	Methylation	EGAHLRARMQSACLL HHHHHHHHHHHHHHH	19.76	16189003
678	S-palmitoylation	RARMQSACLLSDMES HHHHHHHHHHCCHHH	4.81	28680068
700	Methylation	CFLEDFVRWYSPRDY CCHHHHHHHCCHHHH	26.97	16189013
793	Acetylation	HAAVLKVKEEESLEN HHHHHHHCCHHHHCC	58.79	23954790
858	S-nitrosylation	AKFGTEKCEHEEEKE HHHCCCCCCCHHHHH	5.41	21278135
858	S-nitrosocysteine	AKFGTEKCEHEEEKE HHHCCCCCCCHHHHH	5.41	-
872	Phosphorylation	EGLERFVSCLLEQPE HHHHHHHHHHHHCCC	9.06	29899451
873	Glutathionylation	GLERFVSCLLEQPEV HHHHHHHHHHHCCCE	4.17	24333276
881	Phosphorylation	LLEQPEVSVTGAGRG HHHCCCEEECCCCCC	16.58	29899451
883	Phosphorylation	EQPEVSVTGAGRGHA HCCCEEECCCCCCHH	17.51	29899451
944	Phosphorylation	RELILRATVPRPAPY CEEEEEEECCCCCCC	25.30	24719451
960	Phosphorylation	KALPQRMYSVLTKED CCCCHHHHHHHCHHH	9.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB3GP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB3GP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB3GP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBG10_HUMAN	RABGAP1L	physical	26496610
RBG1L_HUMAN	RABGAP1L	physical	26496610
SRRT_HUMAN	SRRT	physical	26496610
CCD94_HUMAN	CCDC94	physical	26496610
DEFM_HUMAN	PDF	physical	26496610
ZC3HE_HUMAN	ZC3H14	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.