dbPTM

PKHG3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PKHG3_MOUSE
UniProt AC	Q4VAC9
Protein Name	Pleckstrin homology domain-containing family G member 3
Gene Name	Plekhg3
Organism	Mus musculus (Mouse).
Sequence Length	1341
Subcellular Localization
Protein Description
Protein Sequence	MPVSTALHQDGSQERPRSLVSTTSSSGSSRDSHSAMEEPTGSEASAQNGTGSPWDRHVPNSNNNSSGWLNMKGPLSPFNGRAGTSPAYHKLSYLGRVVREIVETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIESIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMQDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRVLKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEATFRVHRVRNDRTFFLFDKILLITKKRGDHFVYKGHIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRSWTHHIKRLILENHHATIPQKAKEAILEMDSYYPSRYRCSPERMKKAWSSQDEVSSHVRQGRRQSEPGHTLFSRATLPSRQQGFEMPGLKGRRKSEPTRHLLRQLSEKARAVGMKHAGSAGALLDFGQPAHAQKQQPEAERAAREELEEEEELVEEEEQRQQSFSGSLEGLAGHDGSEKVPGPELPGSEEEEEEEESLAVAEQGKRHRESEGSKGCRRPSNRSPTSAEKRMSFESVSSLPEVETDPEPGAEQEAFAALEGPSTEEMPSDPEFPEALETQLHAPKGLLGVDNPAAVVDFVEPEGSEDLKPLSSEEEEEEEMEAAQEPESLLPPSVLDQASVIAERFASSFSRRSSLAIEDGKSSGLGTPRLISRSSSVLSLEGSDKGLARWSSIGDSLSNPPTPEVIIGADMVTDNGPSVNGTESPSAGSGCPTEQDRSSCKKKESALSTRDRQLLDKIKNYYENAEHHDAGFSIRRRESLSYIPKGLVRSSVSRFNSLPKPDSEPAAPVGYKRPGSSRPASWTLFDLPGPRTDKGDPAPITDAEFCPSSEIAKIWERMESSERSPRTGSGQSQANGFELQEPLFILEEHELGAITEESAVASPESASPTEQPSPAHLARELKELVKELSSSVQGELVTPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKNIKAARPPLQWEKVTPDQEEQVPSISGLPEEAGELSGGKARRKPVLSLLSYEQLVAQEHGTSKSSAAVETSPRRFSFSPSAVSPRTTSPGARSSARSPLSPFDTETFNWPDVRELCSKYTSHDKTAQVESSWPRSLLVNRSRSLPENIVEPPMSGKADRCCGLNTHRRLGDGEASQPPLPESPPQSQLNGGDALYVTADLTLENNQRVIIMEKGPHPSSTVGLEEDSGKESSSPVALKGQGQGFQASAEYQPKEHGPRDSADTNKQGRVRNLREKFQALNSVG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TALHQDGSQERPRSL CCCCCCCCCCCCCCE	36.84	26824392
18	Phosphorylation	GSQERPRSLVSTTSS CCCCCCCCEEEECCC	35.49	29472430
24	Phosphorylation	RSLVSTTSSSGSSRD CCEEEECCCCCCCCC	23.69	29514104
25	Phosphorylation	SLVSTTSSSGSSRDS CEEEECCCCCCCCCC	36.30	29514104
76	Phosphorylation	LNMKGPLSPFNGRAG CCCCCCCCCCCCCCC	30.49	27087446
88	Phosphorylation	RAGTSPAYHKLSYLG CCCCCHHHHHHHHHH	11.67	29514104
104	Phosphorylation	VVREIVETERMYVQD HHHHHHHHHCHHHHH	20.28	24719451
300	Phosphorylation	KGPDLTTYGELVLEA CCCCCCCHHHHHHEE	11.90	26239621
308	Phosphorylation	GELVLEATFRVHRVR HHHHHEEEEEEEECC	11.55	26239621
400	Phosphorylation	ILENHHATIPQKAKE HHHCCCCCCCHHHHH	28.91	-
406	Ubiquitination	ATIPQKAKEAILEMD CCCCHHHHHHHHHCC	55.50	22790023
423	Phosphorylation	YPSRYRCSPERMKKA CCCCCCCCHHHHHHH	22.31	23684622
432	Phosphorylation	ERMKKAWSSQDEVSS HHHHHHHHCHHHHHH	23.99	26239621
433	Phosphorylation	RMKKAWSSQDEVSSH HHHHHHHCHHHHHHH	30.83	23684622
438	Phosphorylation	WSSQDEVSSHVRQGR HHCHHHHHHHHHHCC	16.81	29233185
439	Phosphorylation	SSQDEVSSHVRQGRR HCHHHHHHHHHHCCC	31.04	29233185
448	Phosphorylation	VRQGRRQSEPGHTLF HHHCCCCCCCCCCCH	43.90	28507225
448 (in isoform 2)	Phosphorylation	-	43.90	28507225
489	Phosphorylation	RHLLRQLSEKARAVG HHHHHHHHHHHHHHC	28.81	-
491	Acetylation	LLRQLSEKARAVGMK HHHHHHHHHHHHCCC	39.53	-
502	Phosphorylation	VGMKHAGSAGALLDF HCCCCCCCHHHHCCC	25.06	25521595
546	Phosphorylation	EEEQRQQSFSGSLEG HHHHHHHHHCCCCCC	17.03	27742792
548	Phosphorylation	EQRQQSFSGSLEGLA HHHHHHHCCCCCCCC	32.49	23737553
550	Phosphorylation	RQQSFSGSLEGLAGH HHHHHCCCCCCCCCC	23.27	25521595
560	Phosphorylation	GLAGHDGSEKVPGPE CCCCCCCCCCCCCCC	40.06	20531401
571	Phosphorylation	PGPELPGSEEEEEEE CCCCCCCCHHHHHHH	39.64	27087446
579 (in isoform 3)	Phosphorylation	-	55.09	22942356
580	Phosphorylation	EEEEEEESLAVAEQG HHHHHHHHHHHHHHH	25.55	30635358
583 (in isoform 3)	Phosphorylation	-	7.95	22942356
603	Phosphorylation	SKGCRRPSNRSPTSA CCCCCCCCCCCCCCH	42.96	27087446
606	Phosphorylation	CRRPSNRSPTSAEKR CCCCCCCCCCCHHHH	36.46	27087446
608	Phosphorylation	RPSNRSPTSAEKRMS CCCCCCCCCHHHHHC	41.64	23375375
609	Phosphorylation	PSNRSPTSAEKRMSF CCCCCCCCHHHHHCC	37.50	27681418
615	Phosphorylation	TSAEKRMSFESVSSL CCHHHHHCCCCHHCC	29.87	20531401
618	Phosphorylation	EKRMSFESVSSLPEV HHHHCCCCHHCCCCC	25.86	20531401
620	Phosphorylation	RMSFESVSSLPEVET HHCCCCHHCCCCCCC	35.12	20531401
621	Phosphorylation	MSFESVSSLPEVETD HCCCCHHCCCCCCCC	45.87	20531401
694	Phosphorylation	SEDLKPLSSEEEEEE CCCCCCCCCHHHHHH	44.20	25195567
695	Phosphorylation	EDLKPLSSEEEEEEE CCCCCCCCHHHHHHH	57.62	-
730	Phosphorylation	VIAERFASSFSRRSS HHHHHHHHHHCCCCC	29.24	29472430
731	Phosphorylation	IAERFASSFSRRSSL HHHHHHHHHCCCCCE	24.66	29176673
733	Phosphorylation	ERFASSFSRRSSLAI HHHHHHHCCCCCEEE	28.82	26239621
736	Phosphorylation	ASSFSRRSSLAIEDG HHHHCCCCCEEECCC	28.70	27087446
737	Phosphorylation	SSFSRRSSLAIEDGK HHHCCCCCEEECCCC	21.73	25521595
745	Phosphorylation	LAIEDGKSSGLGTPR EEECCCCCCCCCCCC	34.86	22817900
746	Phosphorylation	AIEDGKSSGLGTPRL EECCCCCCCCCCCCE	41.33	19060867
750	Phosphorylation	GKSSGLGTPRLISRS CCCCCCCCCCEEECC	15.41	19060867
755	Phosphorylation	LGTPRLISRSSSVLS CCCCCEEECCCCEEE	30.60	26745281
757	Phosphorylation	TPRLISRSSSVLSLE CCCEEECCCCEEEEC	21.85	27087446
758	Phosphorylation	PRLISRSSSVLSLEG CCEEECCCCEEEECC	24.29	27087446
759	Phosphorylation	RLISRSSSVLSLEGS CEEECCCCEEEECCC	28.46	25521595
762	Phosphorylation	SRSSSVLSLEGSDKG ECCCCEEEECCCCCH	23.40	27087446
766	Phosphorylation	SVLSLEGSDKGLARW CEEEECCCCCHHCCH	27.12	27818261
775	Phosphorylation	KGLARWSSIGDSLSN CHHCCHHHCCHHCCC	24.51	-
828	Phosphorylation	SSCKKKESALSTRDR HHHHHHHHHHHHHHH	43.31	-
831	Phosphorylation	KKKESALSTRDRQLL HHHHHHHHHHHHHHH	22.55	-
862	Phosphorylation	FSIRRRESLSYIPKG CCCCCHHHHHCCCCC	22.32	26824392
864	Phosphorylation	IRRRESLSYIPKGLV CCCHHHHHCCCCCHH	30.23	26824392
865	Phosphorylation	RRRESLSYIPKGLVR CCHHHHHCCCCCHHC	26.91	29550500
880	Phosphorylation	SSVSRFNSLPKPDSE CCHHCCCCCCCCCCC	43.25	26239621
899	Phosphorylation	VGYKRPGSSRPASWT CCCCCCCCCCCCEEE	26.34	21454597
900	Phosphorylation	GYKRPGSSRPASWTL CCCCCCCCCCCEEEE	48.47	26239621
904	Phosphorylation	PGSSRPASWTLFDLP CCCCCCCEEEEEECC	24.23	26824392
906	Phosphorylation	SSRPASWTLFDLPGP CCCCCEEEEEECCCC	18.30	21743459
947	Phosphorylation	RMESSERSPRTGSGQ HHHCCCCCCCCCCCC	18.06	26824392
1053	Phosphorylation	VYQLARQYSLRIKNI HHHHHHHHHHHCCCC	12.24	26643407
1054	Phosphorylation	YQLARQYSLRIKNIK HHHHHHHHHHCCCCC	11.66	26643407
1082	Phosphorylation	DQEEQVPSISGLPEE CHHHCCCCCCCCCHH	30.45	29514104
1094	Phosphorylation	PEEAGELSGGKARRK CHHHCCCCCCCCCCC	40.99	29514104
1105	Phosphorylation	ARRKPVLSLLSYEQL CCCCCHHHHHCHHHH	27.74	26060331
1108	Phosphorylation	KPVLSLLSYEQLVAQ CCHHHHHCHHHHHHH	31.73	26060331
1109	Phosphorylation	PVLSLLSYEQLVAQE CHHHHHCHHHHHHHH	13.99	26060331
1122	Phosphorylation	QEHGTSKSSAAVETS HHHCCCCCCCCCCCC	25.61	27717184
1123	Phosphorylation	EHGTSKSSAAVETSP HHCCCCCCCCCCCCC	24.80	29514104
1128	Phosphorylation	KSSAAVETSPRRFSF CCCCCCCCCCCCEEC	37.12	27087446
1129	Phosphorylation	SSAAVETSPRRFSFS CCCCCCCCCCCEECC	11.69	27087446
1134	Phosphorylation	ETSPRRFSFSPSAVS CCCCCCEECCCCCCC	24.01	27087446
1136	Phosphorylation	SPRRFSFSPSAVSPR CCCCEECCCCCCCCC	19.42	27087446
1138	Phosphorylation	RRFSFSPSAVSPRTT CCEECCCCCCCCCCC	39.85	23684622
1141	Phosphorylation	SFSPSAVSPRTTSPG ECCCCCCCCCCCCCC	14.37	27087446
1151	Phosphorylation	TTSPGARSSARSPLS CCCCCCCCCCCCCCC	28.02	26239621
1152	Phosphorylation	TSPGARSSARSPLSP CCCCCCCCCCCCCCC	23.34	21082442
1155	Phosphorylation	GARSSARSPLSPFDT CCCCCCCCCCCCCCC	29.88	27087446
1158	Phosphorylation	SSARSPLSPFDTETF CCCCCCCCCCCCCCC	27.23	27087446
1162	Phosphorylation	SPLSPFDTETFNWPD CCCCCCCCCCCCCHH	36.99	26745281
1164	Phosphorylation	LSPFDTETFNWPDVR CCCCCCCCCCCHHHH	25.10	26745281
1199	Phosphorylation	RSLLVNRSRSLPENI HHHHCCCCCCCCCCC	22.48	22942356
1201	Phosphorylation	LLVNRSRSLPENIVE HHCCCCCCCCCCCCC	49.90	25521595
1212	Phosphorylation	NIVEPPMSGKADRCC CCCCCCCCCCCCCCC	42.80	29514104
1240	Phosphorylation	SQPPLPESPPQSQLN CCCCCCCCCCHHHCC	39.68	21659604
1244	Phosphorylation	LPESPPQSQLNGGDA CCCCCCHHHCCCCCE	42.27	21659604
1276	Phosphorylation	MEKGPHPSSTVGLEE EECCCCCCCCCCCCC	35.29	25619855
1277	Phosphorylation	EKGPHPSSTVGLEED ECCCCCCCCCCCCCC	31.40	25619855
1278	Phosphorylation	KGPHPSSTVGLEEDS CCCCCCCCCCCCCCC	23.95	25619855
1285	Phosphorylation	TVGLEEDSGKESSSP CCCCCCCCCCCCCCC	55.85	21082442
1289	Phosphorylation	EEDSGKESSSPVALK CCCCCCCCCCCEEEC	39.33	25619855
1290	Phosphorylation	EDSGKESSSPVALKG CCCCCCCCCCEEECC	39.49	25619855
1291	Phosphorylation	DSGKESSSPVALKGQ CCCCCCCCCEEECCC	32.45	25521595
1339	Phosphorylation	EKFQALNSVG----- HHHHHHHCCC-----	29.12	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PKHG3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PKHG3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PKHG3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PKHG3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PKHG3_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502; SER-737; SER-862AND SER-1134, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759; SER-762; SER-766;SER-1134 AND SER-1141, AND MASS SPECTROMETRY.	17242355 [Abstract]