dbPTM

MYO19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYO19_MOUSE
UniProt AC	Q5SV80
Protein Name	Unconventional myosin-XIX {ECO:0000303\|PubMed:24825904}
Gene Name	Myo19 {ECO:0000303\|PubMed:24825904, ECO:0000312\|MGI:MGI:1913446}
Organism	Mus musculus (Mouse).
Sequence Length	963
Subcellular Localization	Mitochondrion outer membrane Peripheral membrane protein . Cytoplasm, cytoskeleton .
Protein Description	Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. [PubMed: 24825904 Motor protein that moves towards the plus-end of actin filaments]
Protein Sequence	MLQQVNGHSLGSDAEGRASLKGDLREFLGGEIPLHQLDDLTKVNPVTLETVLRCLQARYTEDIFYTNAGCTLVALNPFKHVPQLYAPELMQEYHAAPQPQKLKPHIFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYAVVAASPTSCENHKIAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGATKDERLQWHLPEGTAFSWLPNPESSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHFVDSEDEALPCQVMDDTKVSVRTSALLLQLPEKMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIYARLFDWLVSVINSSICADSKSWTAFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQEEYEVEGLEWSFVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSAAQLQTRIESTLAGRPCLGHNKLSREPSFVVVHFAGPVRYHTAGLVEKNKDPVPPELTELLQQSQDPLLTMLFPANPEEKTQEELSGQSRAPALTVVSKFKASLEQLLQVLHNTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFIERYKLLRRLGPRMSSGLGGLEPAEGSSEQPLCAKEATLQPLLQDILHALPALIQTAATPSDPAKNTQIPLYCGRTKIFMTDSMLELLECGRAQMLEQCARCIQCGWRRHRLQKQEKQRRAAVLIQAAFRSWLTRKHIRRLHIAATVIKHAWHKWRIRMACLASKELDGMEEKPMPQAPGTLRSSMSPAHTRFLGAIIHLWPLGLVLANSADGVRGFQRKLVAHACLRLPSDRPSNKVQTPQQDQAGITSIRALPQGSIKFHCRKSPLQYADICPDPSASCVTGFNQILLESHRPVQV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
348	Phosphorylation	PEKMLLESMQIRTIK CHHHHHHHCCCCEEC	18.89	-
538	Phosphorylation	HFAGPVRYHTAGLVE EECCCCEEECCCHHH	12.08	-
596	Phosphorylation	APALTVVSKFKASLE CCHHHHHHHHHHHHH	28.21	28059163
830	Ubiquitination	RMACLASKELDGMEE HHHHHHCCCCCCCCC	57.60	22790023
838	Ubiquitination	ELDGMEEKPMPQAPG CCCCCCCCCCCCCCC	33.05	22790023
852	Phosphorylation	GTLRSSMSPAHTRFL CCHHCCCCHHHHHHH	22.38	23140645
896	Phosphorylation	HACLRLPSDRPSNKV HHHHCCCCCCCCCCC	51.33	28507225
900	Phosphorylation	RLPSDRPSNKVQTPQ CCCCCCCCCCCCCCC	50.61	29472430
923	Phosphorylation	IRALPQGSIKFHCRK EEEECCCCEEEEECC	19.84	30352176

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MYO19_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYO19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYO19_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MYO19_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYO19_MOUSE

Related Literatures of Post-Translational Modification