DX39A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DX39A_MOUSE
• UniProt AC: Q8VDW0
• Protein Name: ATP-dependent RNA helicase DDX39A
• Gene Name: Ddx39a
• Organism: Mus musculus (Mouse).
• Sequence Length: 427
• Subcellular Localization: Nucleus. Cytoplasm. Can translocate to the cytoplasm in the presence of MX1..
• Protein Description: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity)..
• Protein Sequence: MAEQDVENELLDYDEDEEPQAPQESTPAPPKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVSVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEDVLKKNCPHVVVGTPGRILALVRSRSLNLRNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKEIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVVIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAVTFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEQDVENE ------CCCCHHHHH	24.13	-
13	Phosphorylation	VENELLDYDEDEEPQ HHHHCCCCCCCCCCC	22.62	24224561
25	Phosphorylation	EPQAPQESTPAPPKK CCCCCCCCCCCCCCC	34.15	21149613
26	Phosphorylation	PQAPQESTPAPPKKD CCCCCCCCCCCCCCC	23.79	21149613
35	Acetylation	APPKKDVKGSYVSIH CCCCCCCCCCEEEEE	52.88	23806337
35	Ubiquitination	APPKKDVKGSYVSIH CCCCCCCCCCEEEEE	52.88	-
35	Malonylation	APPKKDVKGSYVSIH CCCCCCCCCCEEEEE	52.88	26320211
37	Phosphorylation	PKKDVKGSYVSIHSS CCCCCCCCEEEEECC	19.35	26824392
38	Phosphorylation	KKDVKGSYVSIHSSG CCCCCCCEEEEECCC	13.59	28833060
40	Phosphorylation	DVKGSYVSIHSSGFR CCCCCEEEEECCCCH	13.32	23684622
43	Phosphorylation	GSYVSIHSSGFRDFL CCEEEEECCCCHHHH	30.41	28833060
44	Phosphorylation	SYVSIHSSGFRDFLL CEEEEECCCCHHHHC	27.99	28066266
52	Ubiquitination	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	-
52	Acetylation	GFRDFLLKPELLRAI CCHHHHCCHHHHHHH	38.30	22826441
130	Ubiquitination	ELAFQISKEYERFSK HHHHHHHHHHHHHHH	66.98	-
145	Phosphorylation	YMPSVKVSVFFGGLS HCCCCEEEEEECCCC	13.90	21454597
152	Phosphorylation	SVFFGGLSIKKDEDV EEEECCCCCCCCHHH	35.32	21454597
164	S-nitrosylation	EDVLKKNCPHVVVGT HHHHHHCCCEEEECC	3.19	24926564
171	Phosphorylation	CPHVVVGTPGRILAL CCEEEECCHHHHHHH	15.80	26824392
190	Acetylation	SLNLRNVKHFVLDEC CCCCCCCCEEHHHHH	34.57	22826441
238	S-nitrosylation	SKEIRPVCRKFMQDP CHHHHHHHHHHCCCC	4.31	24926564
240	Acetylation	EIRPVCRKFMQDPME HHHHHHHHHCCCCCE	39.81	22826441
267	Ubiquitination	GLQQYYVKLKDSEKN HHHHEEEEECCCHHH	33.43	-
333	Acetylation	LSRYQQFKDFQRRIL HHHHHHHHHHHHHHH	53.98	23806337
333	Ubiquitination	LSRYQQFKDFQRRIL HHHHHHHHHHHHHHH	53.98	-
420	Phosphorylation	LPEEIDISTYIEQSR CCCCCCHHHHHHCCC	16.06	26643407
421	Phosphorylation	PEEIDISTYIEQSR- CCCCCHHHHHHCCC-	28.93	26643407
422	Phosphorylation	EEIDISTYIEQSR-- CCCCHHHHHHCCC--	8.82	21149613
426	Phosphorylation	ISTYIEQSR------ HHHHHHCCC------	27.45	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DX39A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DX39A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DX39A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DX39A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.