NVL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NVL_MOUSE
• UniProt AC: Q9DBY8
• Protein Name: Nuclear valosin-containing protein-like
• Gene Name: Nvl
• Organism: Mus musculus (Mouse).
• Sequence Length: 855
• Subcellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm . Associates with pre-ribosomal particles in the nucleus.
• Protein Description: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. May play a role in 60S ribosomal subunit biogenesis..
• Protein Sequence: MKPRPGVFVDRKLKQRVIQYLSSNRCGKYVDTGILASDLQRLYSVDYGRRKRNAFRIQVEKVFSIISSEKELKNLKELEDGHLAKRARQDEEDEYTESYSDDDSNMEDYPDPQSANPMNSSLLSLYRRGNSESVSTTPKWGQREATTSTPLLTSKTGSVPLKTPARESEGGWFIDKTPGGKKESLPLDLSDDQSNSKKQDSEIQILKDSSLLESDKKRKGRAKGKGNKRKTENLQEVDGEIEALLQKKAKARSTELQISNVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFDQAVSNAPCIVFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREVCLGIPDEAARERILQTLCRKLRLPETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKQQAQQKKKPEIEGLPSEGDQEERLGAEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALAEVQPSAKREGFVTVPNVTWADIGALEDIRDELIMAILAPVRNPDQFRTLGLGTPAGILLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLETRQQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAILKTITKNGTKPPLDEDVNLETIANDLRCNCYTGADLTALVREASLCALRQEITAQKNGVGAGELKVSHKHFEDAFKKVKPSISIKDQVMYEALQRSLSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	SDLQRLYSVDYGRRK HHHHHHHCCCCCCCC	17.07	26643407
70	Acetylation	FSIISSEKELKNLKE HHHHCCHHHHCCHHH	71.00	23806337
131	Phosphorylation	SLYRRGNSESVSTTP HHHHCCCCCCCCCCC	33.79	25521595
133	Phosphorylation	YRRGNSESVSTTPKW HHCCCCCCCCCCCCC	22.61	30635358
136	Phosphorylation	GNSESVSTTPKWGQR CCCCCCCCCCCCCCC	44.99	29550500
137	Phosphorylation	NSESVSTTPKWGQRE CCCCCCCCCCCCCCC	18.50	29550500
146	Phosphorylation	KWGQREATTSTPLLT CCCCCCCCCCCCEEE	19.27	26745281
147	Phosphorylation	WGQREATTSTPLLTS CCCCCCCCCCCEEEC	37.34	26643407
148	Phosphorylation	GQREATTSTPLLTSK CCCCCCCCCCEEECC	24.55	24453211
149	Phosphorylation	QREATTSTPLLTSKT CCCCCCCCCEEECCC	18.83	25266776
153	Phosphorylation	TTSTPLLTSKTGSVP CCCCCEEECCCCCCC	35.54	28066266
154	Phosphorylation	TSTPLLTSKTGSVPL CCCCEEECCCCCCCC	28.34	26745281
155	Acetylation	STPLLTSKTGSVPLK CCCEEECCCCCCCCC	52.23	23806337
177	Phosphorylation	GGWFIDKTPGGKKES CCEEEECCCCCCCCC	24.34	28066266
184	Phosphorylation	TPGGKKESLPLDLSD CCCCCCCCCCCCCCC	44.13	25619855
190	Phosphorylation	ESLPLDLSDDQSNSK CCCCCCCCCCCCCCC	38.52	27087446
194	Phosphorylation	LDLSDDQSNSKKQDS CCCCCCCCCCCCCHH	50.49	27742792
196	Phosphorylation	LSDDQSNSKKQDSEI CCCCCCCCCCCHHHH	46.61	27742792
201	Phosphorylation	SNSKKQDSEIQILKD CCCCCCHHHHHHHHC	33.82	23984901
209	Phosphorylation	EIQILKDSSLLESDK HHHHHHCHHHHCHHH	22.69	28066266
210	Phosphorylation	IQILKDSSLLESDKK HHHHHCHHHHCHHHC	47.29	28066266
214	Phosphorylation	KDSSLLESDKKRKGR HCHHHHCHHHCHHCC	55.49	22817900
231	Phosphorylation	GKGNKRKTENLQEVD CCCCHHHCCCHHHHH	33.85	27600695
507	Phosphorylation	PEIEGLPSEGDQEER CCCCCCCCCCCHHHH	60.29	22817900
613	Phosphorylation	FRTLGLGTPAGILLA HHCCCCCCCCEEEEC	18.27	-
837	Phosphorylation	AFKKVKPSISIKDQV HHHHCCCCCCHHHHH	24.21	-
839	Phosphorylation	KKVKPSISIKDQVMY HHCCCCCCHHHHHHH	28.11	-
854	Phosphorylation	EALQRSLSQ------ HHHHHHHCC------	34.78	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NVL_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NVL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NVL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR74_HUMAN	WDR74	physical	28416111

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.