RS8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RS8_MOUSE
• UniProt AC: P62242
• Protein Name: 40S ribosomal protein S8
• Gene Name: Rps8
• Organism: Mus musculus (Mouse).
• Sequence Length: 208
• Subcellular Localization: Cytoplasm. Membrane ; Lipid-anchor . Localized in cytoplasmic mRNP granules containing untranslated mRNAs..
• Protein Sequence: MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGISRDNWH ------CCCCCCCHH	26.95	-
4	Phosphorylation	----MGISRDNWHKR ----CCCCCCCHHHC	28.05	23375375
37	Ubiquitination	GRPAANTKIGPRRIH CCCCCCCCCCCCEEE	45.53	22790023
37	Acetylation	GRPAANTKIGPRRIH CCCCCCCCCCCCEEE	45.53	23806337
71	S-palmitoylation	NFSWGSECCTRKTRI CCCCCHHHCCCCCEE	2.84	28526873
71	Glutathionylation	NFSWGSECCTRKTRI CCCCCHHHCCCCCEE	2.84	24333276
72	S-palmitoylation	FSWGSECCTRKTRII CCCCHHHCCCCCEEE	3.46	28526873
72	Glutathionylation	FSWGSECCTRKTRII CCCCHHHCCCCCEEE	3.46	24333276
83	Phosphorylation	TRIIDVVYNASNNEL CEEEEEEEECCCCCE	12.59	25367039
98	Ubiquitination	VRTKTLVKNCIVLID ECCHHHHCCEEEEEC	49.57	-
98	Acetylation	VRTKTLVKNCIVLID ECCHHHHCCEEEEEC	49.57	22826441
100	S-palmitoylation	TKTLVKNCIVLIDST CHHHHCCEEEEECCC	1.56	28526873
100	Glutathionylation	TKTLVKNCIVLIDST CHHHHCCEEEEECCC	1.56	24333276
115	Phosphorylation	PYRQWYESHYALPLG CCHHHHHHCCCCCCC	13.20	29514104
125	Malonylation	ALPLGRKKGAKLTPE CCCCCCCCCCCCCHH	63.84	26320211
128	Malonylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	26320211
128	Acetylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	23806337
128	Ubiquitination	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	-
128	Succinylation	LGRKKGAKLTPEEEE CCCCCCCCCCHHHHH	62.66	-
130	Phosphorylation	RKKGAKLTPEEEEIL CCCCCCCCHHHHHHH	28.13	25521595
139	Acetylation	EEEEILNKKRSKKIQ HHHHHHCHHHHHHHH	46.23	23864654
157	Acetylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	23806337
157	Succinylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	-
157	Malonylation	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	26320211
157	Ubiquitination	DERKKNAKISSLLEE HHHHHHHHHHHHHHH	53.14	-
159	Phosphorylation	RKKNAKISSLLEEQF HHHHHHHHHHHHHHH	17.77	27087446
160	Phosphorylation	KKNAKISSLLEEQFQ HHHHHHHHHHHHHHH	40.21	25521595
170	Acetylation	EEQFQQGKLLACIAS HHHHHHCCEEHHHHC	35.67	22826441
170	Ubiquitination	EEQFQQGKLLACIAS HHHHHHCCEEHHHHC	35.67	-
182	Glutathionylation	IASRPGQCGRADGYV HHCCCCCCCCCCCEE	5.02	24333276
193	Acetylation	DGYVLEGKELEFYLR CCEEECCCCHHHHHH	50.15	23236377
193	Ubiquitination	DGYVLEGKELEFYLR CCEEECCCCHHHHHH	50.15	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RS8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RS8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RS8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RS8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND MASSSPECTROMETRY.
PubMed: 17242355