dbPTM

GNL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GNL1_MOUSE
UniProt AC	P36916
Protein Name	Guanine nucleotide-binding protein-like 1
Gene Name	Gnl1
Organism	Mus musculus (Mouse).
Sequence Length	607
Subcellular Localization
Protein Description	Possible regulatory or functional link with the histocompatibility cluster..
Protein Sequence	MPRKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAAREQVLQPVSAEVLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQEYLGKIHGAYTSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGELGLALVLVLNKVDLAPPALVVAWKHYFHQCYPQLHIVLFTSFPRDTRTPQEPGGVLKKNRRRGKGWTRALGPEQLLRACEAITVGKVDLSSWREKIARDVAGASWGNVSGEEEEEEDGPAVLVEQLTDSAMEPTGPSRERYKDGVVTIGCIGFPNVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTSVGYLASRIPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLAVDGRLSLCFYPPGYSEQRGTWESHPETAELVLSQGRVGPAGDEEEEEEEELSSSCEEEGEEDRDADEEGEGDEDTPTSDPGSCLTARNPYALLGEDEC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPRKKPFSVKQKKKQ CCCCCCCCHHHHHHH	36.61	29899451
32	Phosphorylation	GLQDGLRSSSNSRSG HHHHHHHCCCCCCCC	43.06	27149854
33	Phosphorylation	LQDGLRSSSNSRSGS HHHHHHCCCCCCCCC	27.40	25338131
34	Phosphorylation	QDGLRSSSNSRSGSR HHHHHCCCCCCCCCH	39.82	25338131
36	Phosphorylation	GLRSSSNSRSGSRER HHHCCCCCCCCCHHH	29.76	25338131
38	Phosphorylation	RSSSNSRSGSRERRE HCCCCCCCCCHHHHH	40.72	29899451
40	Phosphorylation	SSNSRSGSRERREEQ CCCCCCCCHHHHHHH	32.01	29899451
48	Phosphorylation	RERREEQTDTSDGES HHHHHHHCCCCCCHH	44.52	27087446
50	Phosphorylation	RREEQTDTSDGESVT HHHHHCCCCCCHHHH	31.91	27087446
51	Phosphorylation	REEQTDTSDGESVTH HHHHCCCCCCHHHHH	46.56	27087446
55	Phosphorylation	TDTSDGESVTHHIRR CCCCCCHHHHHHHHH	37.53	27742792
57	Phosphorylation	TSDGESVTHHIRRLN CCCCHHHHHHHHHHH	19.60	27742792
68	Phosphorylation	RRLNQQPSQGLGPRG HHHHCCCCCCCCCCC	32.32	22324799
89	Phosphorylation	RLHFERDSREEVERR EEEECCCCHHHHHHH	48.06	29899451
165	Phosphorylation	KIHGAYTSEKLSYFE HHHCCCCHHHHHHHH	21.76	24704852
170	Phosphorylation	YTSEKLSYFEHNLET CCHHHHHHHHHHHHH	24.35	24704852
319	Phosphorylation	ARDVAGASWGNVSGE HHHHCCCCCCCCCCC	34.30	26745281
324	Phosphorylation	GASWGNVSGEEEEEE CCCCCCCCCCCHHCC	44.48	27087446
342	Phosphorylation	AVLVEQLTDSAMEPT EEEEEECCCCCCCCC	27.83	23984901
344	Phosphorylation	LVEQLTDSAMEPTGP EEEECCCCCCCCCCC	25.04	23984901
349	Phosphorylation	TDSAMEPTGPSRERY CCCCCCCCCCCHHHH	48.71	23984901
352	Phosphorylation	AMEPTGPSRERYKDG CCCCCCCCHHHHCCC	48.39	23984901
504	Phosphorylation	DVYRAANSLLRLAVD HHHHHHHHHHHHHHC	24.85	25338131
561	Phosphorylation	EEEEEELSSSCEEEG HHHHHHHHHHCHHCC	24.40	-
562	Phosphorylation	EEEEELSSSCEEEGE HHHHHHHHHCHHCCC	52.19	25521595
563	Phosphorylation	EEEELSSSCEEEGEE HHHHHHHHCHHCCCC	23.36	25521595
584	Phosphorylation	EGEGDEDTPTSDPGS CCCCCCCCCCCCCCC	26.81	25521595
586	Phosphorylation	EGDEDTPTSDPGSCL CCCCCCCCCCCCCCC	48.10	25293948
587	Phosphorylation	GDEDTPTSDPGSCLT CCCCCCCCCCCCCCC	42.91	25521595
591	Phosphorylation	TPTSDPGSCLTARNP CCCCCCCCCCCCCCC	16.02	21149613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GNL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GNL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GNL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GNL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GNL1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 AND THR-48, AND MASSSPECTROMETRY.	19367708 [Abstract]