MIC19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC19_MOUSE
• UniProt AC: Q9CRB9
• Protein Name: MICOS complex subunit Mic19
• Gene Name: Chchd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 227
• Subcellular Localization: Mitochondrion inner membrane ; Lipid-anchor ; Intermembrane side . Cytoplasm . Nucleus . Mitochondrion .
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology..
• Protein Sequence: MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGGTASTRR ------CCCCCCCCE		21081504
2	N-myristoyl glycine	------MGGTASTRR ------CCCCCCCCE		-
11	Phosphorylation	TASTRRVTFEADENE CCCCCEEEEECCCCC		22817900
29	Phosphorylation	VVKGIRLSENVIDRM EEECEEECHHHHHHH		23737553
39	Phosphorylation	VIDRMKESSPSGSKS HHHHHHHCCCCCCHH		23140645
40	Phosphorylation	IDRMKESSPSGSKSQ HHHHHHCCCCCCHHH		23684622
46	Phosphorylation	SSPSGSKSQRYSSVY CCCCCCHHHCCHHCC		28833060
49	Phosphorylation	SGSKSQRYSSVYGAS CCCHHHCCHHCCCCC		25521595
50	Phosphorylation	GSKSQRYSSVYGASV CCHHHCCHHCCCCCC		25521595
51	Phosphorylation	SKSQRYSSVYGASVS CHHHCCHHCCCCCCC		27742792
53	Phosphorylation	SQRYSSVYGASVSDE HHCCHHCCCCCCCHH		27087446
56	Phosphorylation	YSSVYGASVSDEDLK CHHCCCCCCCHHHHH		27742792
58	Phosphorylation	SVYGASVSDEDLKRR HCCCCCCCHHHHHHH		25521595
63	Acetylation	SVSDEDLKRRVAEEL CCCHHHHHHHHHHHH		156595
63	Ubiquitination	SVSDEDLKRRVAEEL CCCHHHHHHHHHHHH		-
63	Malonylation	SVSDEDLKRRVAEEL CCCHHHHHHHHHHHH		26320211
76	Malonylation	ELALEQAKKESEHQR HHHHHHHHHHHHHHH		26320211
76	Succinylation	ELALEQAKKESEHQR HHHHHHHHHHHHHHH		23954790
79	Phosphorylation	LEQAKKESEHQRRLK HHHHHHHHHHHHHHH		25338131
103	Phosphorylation	AAANEQLTRAVLRER HHHHHHHHHHHHHHH		25890499
112	Phosphorylation	AVLRERISSEEERMK HHHHHHCCCHHHHHH		26824392
113	Phosphorylation	VLRERISSEEERMKA HHHHHCCCHHHHHHH		25266776
130	Acetylation	LARQLEEKDRVMRKQ HHHHHHHHHHHHHHH		23201123
136	Malonylation	EKDRVMRKQDAFYKE HHHHHHHHHHHHHHH		26320211
141	Phosphorylation	MRKQDAFYKEQLARL HHHHHHHHHHHHHHH		22817900
142	Succinylation	RKQDAFYKEQLARLE HHHHHHHHHHHHHHH		23954790
142	Acetylation	RKQDAFYKEQLARLE HHHHHHHHHHHHHHH		21728379
152	Phosphorylation	LARLEERSSEFYKVT HHHHHHHCHHHHHCC		23140645
153	Phosphorylation	ARLEERSSEFYKVTT HHHHHHCHHHHHCCH		23140645
157	Succinylation	ERSSEFYKVTTEEYQ HHCHHHHHCCHHHHH		23954790
157	Ubiquitination	ERSSEFYKVTTEEYQ HHCHHHHHCCHHHHH		-
157	Acetylation	ERSSEFYKVTTEEYQ HHCHHHHHCCHHHHH		23864654
165	Acetylation	VTTEEYQKAAEEVEA CCHHHHHHHHHHHHH		23201123
173	Ubiquitination	AAEEVEAKFKRYEYH HHHHHHHHHHHHCCC		22790023
173	Acetylation	AAEEVEAKFKRYEYH HHHHHHHHHHHHCCC		21728379
179	Phosphorylation	AKFKRYEYHPVCADL HHHHHHCCCHHHHHH		25195567
189	Acetylation	VCADLQTKILQCYRQ HHHHHHHHHHHHHHH		23864654
189	Malonylation	VCADLQTKILQCYRQ HHHHHHHHHHHHHHH		26320211
198	Phosphorylation	LQCYRQNTQQTLSCS HHHHHHCCCHHHHHH		-
203	Phosphorylation	QNTQQTLSCSALASQ HCCCHHHHHHHHHHH		-
205	Phosphorylation	TQQTLSCSALASQYM CCHHHHHHHHHHHHH		-
209	Phosphorylation	LSCSALASQYMHCVN HHHHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	T	Phosphorylation	Kinase	PRKACA	P05132	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC19_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MIC19_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.