P5CS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P5CS_MOUSE
• UniProt AC: Q9Z110
• Protein Name: Delta-1-pyrroline-5-carboxylate synthase
• Gene Name: Aldh18a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 795
• Subcellular Localization: Mitochondrion inner membrane .
• Protein Description: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine..
• Protein Sequence: MLRHMHRSGVQPFRQRLLPWVQSIAVPRSNRVQPSAIRHVRSWSNIPFITVPLSRAHGKPFAHRSELKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNHLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHDEQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPAEPNSDLQGVNVISVKDNDSLAARLAVEMKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGLGGMEAKVKAALWALQGGTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPTVEQQGEMARSGGRMLATLEPEQRAEIINHLADLLTDQREEILLANKKDLEEAEGRLASPLLKRLSLSTSKLNSLAIGLRQIAASSQESVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAIQLVNTREEVEDLCRLDKIIDLIIPRGSSQLVRDIQKAAKGIPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYLTFSPSEVKSLRTEYGDLEVCIEVVDSVQEAIDHIHKYGSSHTDVIVTENEKTAEFFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGQDHVVSDFSEHGSLKYLHENLPVPQRNFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	RLLPWVQSIAVPRSN HHHHHHHHCCCCCCC	11.69	41301637
79	Phosphorylation	RIVVKLGSAVVTRGD HHEEECCCEEEECCC	28.46	28066266
88	S-palmitoylation	VVTRGDECGLALGRL EEECCCHHHHHHHHH	6.87	28680068
124	Acetylation	SGAVAFGKQRLRHEI ECHHHHCHHHHHHHH	26.28	22733758
143	Phosphorylation	SVRQALHSGQNHLKE HHHHHHHHCCCHHHH	42.81	28285833
248	Phosphorylation	ISVKDNDSLAARLAV EEECCCCHHHHHHHH	26.60	22817900
311	Succinylation	GLGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	23806337
311	Succinylation	GLGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	-
311	Acetylation	GLGGMEAKVKAALWA CCCHHHHHHHHHHHH	30.84	23806337
347	Succinylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	23806337
347	Succinylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	-
347	Acetylation	ITDIVEGKKVGTFFS EEEHHCCCEEEEECC	30.68	23806337
348	Acetylation	TDIVEGKKVGTFFSE EEHHCCCEEEEECCC	57.67	22826441
420	Phosphorylation	EAEGRLASPLLKRLS HHCHHHHHHHHHHHC	22.22	26745281
424	Acetylation	RLASPLLKRLSLSTS HHHHHHHHHHCCCHH	60.00	23806337
424	Succinylation	RLASPLLKRLSLSTS HHHHHHHHHHCCCHH	60.00	23806337
427	Phosphorylation	SPLLKRLSLSTSKLN HHHHHHHCCCHHHHH	25.06	28833060
429	Phosphorylation	LLKRLSLSTSKLNSL HHHHHCCCHHHHHHH	27.53	28833060
430	Phosphorylation	LKRLSLSTSKLNSLA HHHHCCCHHHHHHHH	34.86	28066266
431	Phosphorylation	KRLSLSTSKLNSLAI HHHCCCHHHHHHHHH	31.60	26745281
550	Acetylation	EDLCRLDKIIDLIIP HHHHHHHHHHHEEEC	46.26	23806337
550	Succinylation	EDLCRLDKIIDLIIP HHHHHHHHHHHEEEC	46.26	-
550	Succinylation	EDLCRLDKIIDLIIP HHHHHHHHHHHEEEC	46.26	23806337
657	Phosphorylation	FASYLTFSPSEVKSL CHHHEEECHHHHHHH	23.45	29514104
674	S-nitrosylation	EYGDLEVCIEVVDSV HCCCHHHHHHHHHHH	1.28	20925432
674	S-nitrosocysteine	EYGDLEVCIEVVDSV HCCCHHHHHHHHHHH	1.28	-
760	Phosphorylation	GLEGLLTTKWLLRGQ CHHHHHHHHHHHCCC	21.86	37009371

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P5CS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P5CS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P5CS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of P5CS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.