dbPTM

PUR6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUR6_MOUSE
UniProt AC	Q9DCL9
Protein Name	Multifunctional protein ADE2
Gene Name	Paics
Organism	Mus musculus (Mouse).
Sequence Length	425
Subcellular Localization
Protein Description
Protein Sequence	MATAVVVNIGKKLYEGKTKEVYELLDTPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVQEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQDCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSDSQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVSVAGRSNGLGPVLSGNTAYPVISCPPITPDWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFGLNNHLVWAKLRASILNTWISLKQADKKVRQCNL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATAVVVNI ------CCEEEEEEC	12.31	-
22	Phosphorylation	EGKTKEVYELLDTPG CCCCHHHHHHHCCCC	11.27	25159016
27	Phosphorylation	EVYELLDTPGRVLLQ HHHHHHCCCCCEEEC	27.84	25159016
36	Acetylation	GRVLLQSKDQITAGN CCEEECCCCCCCCCH	40.46	23806337
36	Ubiquitination	GRVLLQSKDQITAGN CCEEECCCCCCCCCH	40.46	22790023
53	Ubiquitination	RKNHLEGKAAISNKI HHHCCCHHHHHHHHH	25.85	-
53	Malonylation	RKNHLEGKAAISNKI HHHCCCHHHHHHHHH	25.85	26320211
63	S-nitrosocysteine	ISNKITSCIFQLLQE HHHHHHHHHHHHHHH	2.43	-
63	S-palmitoylation	ISNKITSCIFQLLQE HHHHHHHHHHHHHHH	2.43	28526873
63	S-nitrosylation	ISNKITSCIFQLLQE HHHHHHHHHHHHHHH	2.43	20925432
105	Phosphorylation	WVCRRIATGSFLKRN HHHHHHHCCCHHHCC	30.87	28833060
107	Phosphorylation	CRRIATGSFLKRNPG HHHHHCCCHHHCCCC	24.05	25521595
110	Acetylation	IATGSFLKRNPGVQE HHCCCHHHCCCCCCC	48.39	23806337
110	Succinylation	IATGSFLKRNPGVQE HHCCCHHHCCCCCCC	48.39	-
110	Malonylation	IATGSFLKRNPGVQE HHCCCHHHCCCCCCC	48.39	26320211
110	Ubiquitination	IATGSFLKRNPGVQE HHCCCHHHCCCCCCC	48.39	-
120	Ubiquitination	PGVQEGYKFYPPKVE CCCCCCCCCCCCCEE	49.64	22790023
120	Acetylation	PGVQEGYKFYPPKVE CCCCCCCCCCCCCEE	49.64	30987071
230	Phosphorylation	SQQKDKQSYRDLKEV HHHCCHHHHHHHHHH	28.07	30352176
231	Phosphorylation	QQKDKQSYRDLKEVT HHCCHHHHHHHHHHC	12.97	29514104
234	Ubiquitination	DKQSYRDLKEVTPEG CHHHHHHHHHHCHHH	3.64	27667366
235	Ubiquitination	KQSYRDLKEVTPEGL HHHHHHHHHHCHHHH	55.20	22790023
238	Phosphorylation	YRDLKEVTPEGLQMV HHHHHHHCHHHHHHH	19.40	28066266
246	Malonylation	PEGLQMVKKNFEWVA HHHHHHHHHHHHHHH	36.34	26320211
247	Malonylation	EGLQMVKKNFEWVAD HHHHHHHHHHHHHHH	56.30	26320211
247	Acetylation	EGLQMVKKNFEWVAD HHHHHHHHHHHHHHH	56.30	22826441
274	Phosphorylation	RVVVLMGSTSDLGHC EEEEEECCCCHHHHH	15.69	-
275	Phosphorylation	VVVLMGSTSDLGHCE EEEEECCCCHHHHHH	22.11	25521595
281	S-nitrosocysteine	STSDLGHCEKIKKAC CCCHHHHHHHHHHHH	5.59	-
281	S-nitrosylation	STSDLGHCEKIKKAC CCCHHHHHHHHHHHH	5.59	20925432
281	S-palmitoylation	STSDLGHCEKIKKAC CCCHHHHHHHHHHHH	5.59	28526873
286	Malonylation	GHCEKIKKACGNFGI HHHHHHHHHHCCCCC	53.00	26320211
295	Glutathionylation	CGNFGIPCELRVTSA HCCCCCCEEEEEEEC	7.90	24333276
304	Malonylation	LRVTSAHKGPDETLR EEEEECCCCCCCCEE	72.37	26320211
309	Phosphorylation	AHKGPDETLRIKAEY CCCCCCCCEEEEEEE	28.81	27149854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUR6_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUR6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUR6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PUR6_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUR6_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-22, AND MASSSPECTROMETRY.	19131326 [Abstract]